NOVOBIOCIN SODIUM SALT

NOVOBIOCIN SODIUM SALT Properties

Melting point	215-220 C
alpha	D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	H2O: soluble50mg/mL
form	White to yellow solid
color	white to faintly beige
PH	7.5 (100g/l, H2O, 25℃)
optical activity	[α]20/D 48±3°, c = 1% in ethanol
Water Solubility	Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck	13,6755
BRN	3892910
Stability	Hygroscopic
FDA UNII	Q9S9NQ5YIY

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317-H319

Precautionary statements

P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

43-36-36/37/38-20/21/22

Safety Statements

36-36/37-26-37/39

WGK Germany

2

RTECS

RD5425000

F

8-10

HS Code

2941 90 00

Toxicity

LD50 orally in Rabbit: 3500 mg/kg

NFPA 704

	0
2		0

NOVOBIOCIN SODIUM SALT price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	491207	Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.	1476-53-5	10g	$289	2024-03-01	Buy
Sigma-Aldrich	46531	Novobiocin sodium salt VETRANAL	1476-53-5	250mg	$101	2024-03-01	Buy
Sigma-Aldrich	1.09874	MSRV Selective supplement	1476-53-5	10vial	$204	2024-03-01	Buy
Sigma-Aldrich	491207	Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.	1476-53-5	1g	$50.5	2022-05-15	Buy
Alfa Aesar	J60928	Novobiocin sodium salt	1476-53-5	1g	$47.9	2024-03-01	Buy

Product number	Packaging	Price	Buy
491207	10g	$289	Buy
46531	250mg	$101	Buy
1.09874	10vial	$204	Buy
491207	1g	$50.5	Buy
J60928	1g	$47.9	Buy

NOVOBIOCIN SODIUM SALT Chemical Properties,Uses,Production

Chemical Properties

crystalline

Uses

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

Uses

antibacterial

Uses

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

brand name

Albamycin (Pharmacia & Upjohn).

Clinical Use

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Purification Methods

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

NOVOBIOCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

NOVOBIOCIN SODIUM SALT Suppliers

Global( 194)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3684	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TopScience Biochemical	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from NOVOBIOCIN SODIUM SALT manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	Novobiocin Sodium 1476-53-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Novobiocin Sodium 1476-53-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-06-25	NOVOBIOCIN SODIUM SALT USP/EP/BP 1476-53-5	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Novobiocin Sodium
1476-53-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Novobiocin Sodium
1476-53-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

NOVOBIOCIN SODIUM SALT USP/EP/BP
1476-53-5
US $1.10 / g
99.9%
Dideu Industries Group Limited

NOVOBIOCIN SODIUM SALT Spectrum

NOVOBIOCIN SODIUM SALT(1476-53-5)¹HNMR

1476-53-5(NOVOBIOCIN SODIUM SALT)Related Search:

2-(Acetylamino)-3-phenyl-2-propenoic acid 4-HYDROXY-7-METHOXYCOUMARIN 4-METHOXY-3-METHYLBENZYL ALCOHOL Methyl 2-acetamidoacrylate 3-AMINOCOUMARIN

NOVOBIOCIN SODIUM SALT MEPHENESIN 3-METHYLHIPPURIC ACID 6-Deoxy-L-glucose 4-METHOXY-4-METHYL-2-PENTANOL

2-Acetamidoacrylic acid Omethoate Sodium chloride Dimethoate 1-(2-METHYLPHENOXY)-2-PROPANOL

Dehydro Phenylalanine (cis/trans Mixture) 2,4-Dimethoxy-3-methylbenzyl alcohol 2-(2,6-dimethylphenoxy)ethanamine

1of4

albamycin(capsule) Albamycinsodium Cathomycinsodium Cathomycinsodiumlyovac Monosodiumnovobiocin Novobiocin,sodiumderiv. Novobiocinmonosodium N-[7-[(3-O-Carbamoyl-4-O,5-C-dimethyl-6-deoxy-β-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-sodiooxy-3-(3-methyl-2-butenyl)benzamide Benzamide, N-7-3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.alpha.-L-lyxo-hexopyranosyloxy-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt 7-[4-(Carbamoyloxy)-tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yl]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-, sodium salt Albadry Albycin sodium Antibiotic from streptomyces spheroides Benzamide, N-[7-[[3-o-(aminocarbonyl)-6-deoxy-5-C-methyl-4-o-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt Novobiocin sodiuM(AlbaMycin) N-[7-[[3-O-(AMinocarbonyl)-6-deoxy-5-C-Methyl-4-O-Methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-Methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-Methyl-2-butenyl)benzaMide MonosodiuM salt NSC 2382 Crystallinic acid MonosodiuM salt Robicina Novobiocin-Na-salt research grade N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-benzamide, sodium salt (1:1) Novobiocin Sodium (U-6591) Sodiumalbamycin Sodiumnovobiocin Vulcamycin MSRV SELECTIVE SUPPLEMENT NOVOBIOCIN MONOSODIUM SALT NOVOBIOCIN NA-SALT NOVOBIOCIN SODIUM SALT STREPTONIVICIN U-6591 Novobiocin sodium salt, Antibiotic for Culture Media Use Only novobiocin sodium crystalline novobiocin sodium usp NOVOBIOCIN SODIUM SALT VETRANAL, 250 NOVOBIOCINE MONOSODIUM FPC(CRM STANDARD) NOVOBIOCIN SODIUM SALT APPOX. 90% Novobiocin Sodium, >98% MSRV Selective Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1) 4-Hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl) benzamido]-8-methylcoumarin-7-yl 3-O-carbamoyl-5,5-di-C-methyl-α-L-lyxofuranoside sodium salt Novobiocin Sodium Salt Standard Novobiocin sodium saL Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate NOVOBIOCIN SODIUM SALT USP/EP/BP Novobiocin Sodium Salt (NVB), 95% NOVOBIOCIN SODIUM ALBAMYCIN Neomycin sodium salt 1476-53-5 C31H35N2NaO11 C31H35N2O11Na BioChemical Antibiotics A to Z Antibiotics Antibiotics N-S Aromatcis