KI16425
- CAS No.
- 355025-24-0
- Chemical Name:
- KI16425
- Synonyms
- CS-88;KI-6425;Debio 0719;Ki16425, >=98%;KI16425 USP/EP/BP;KI-16425; KI 16425;Ki16425 (Debio 0719);KI16425;KI-16425; KI 16425;Ki 16425, competitive, potent and reversible antagonist to LPA;Ki 16425, 98%, competitive, potent and reversible antagonist to LPA
- CBNumber:
- CB9497429
- Molecular Formula:
- C23H23ClN2O5S
- Molecular Weight:
- 474.96
- MDL Number:
- MFCD06798341
- MOL File:
- 355025-24-0.mol
- MSDS File:
- SDS
| Melting point | 59.5-60.5 °C |
|---|---|
| Boiling point | 623.7±55.0 °C(Predicted) |
| Density | 1.353 |
| storage temp. | -20°C |
| solubility | DMSO: 16 mg/mL |
| form | solid |
| pka | 4.32±0.10(Predicted) |
| color | white |
| FDA UNII | 83W49JT69B |
KI16425 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0971 | Ki 16425 ≥98% (HPLC) | 355025-24-0 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0971 | Ki 16425 ≥98% (HPLC) | 355025-24-0 | 25mg | $478 | 2024-03-01 | Buy |
| Cayman Chemical | 10012659 | Ki 16425 ≥95% | 355025-24-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10012659 | Ki 16425 ≥95% | 355025-24-0 | 5mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 10012659 | Ki 16425 ≥95% | 355025-24-0 | 10mg | $142 | 2024-03-01 | Buy |
KI16425 Chemical Properties,Uses,Production
Description
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-
Uses
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.
Uses
Ki 16425 has been used as a chemical inhibitor to study the regulation of LPA (lysophosphatidic acid) on LPAR(LPA receptor) subtypes.
Definition
ChEBI: 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid is a member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid. It is a member of isoxazoles, a carbamate ester, a member of monochlorobenzenes, an organic sulfide and a monocarboxylic acid.
Biochem/physiol Actions
Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.
storage
Store at +4°C
References
[1]. ohta h, sato k, murata n, damirin a, malchinkhuu e, kon j, kimura t, tobo m, yamazaki y, watanabe t, yagi m, sato m, suzuki r, murooka h, sakai t, nishitoba t, im ds, nochi h, tamoto k, tomura h, okajima f. ki16425, a subtype-selective antagonist for edg-family lysophosphatidic acid receptors. mol pharmacol. 2003 oct;64(4):994-1005.
[2]. ruisanchez é, dancs p, kerék m, németh t, faragó b, balogh a, patil r, jennings bl, liliom k, malik ku, smrcka av, tigyi g, benyó z. lysophosphatidic acid induces vasodilation mediated by lpa1 receptors, phospholipase c, and endothelial nitric oxide synthase. faseb j. 2014 feb;28(2):880-90.
[3]. su sc, hu x, kenney pa, merrill mm, babaian kn, zhang xy, maity t, yang sf, lin x, wood cg. autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma. clin cancer res. 2013 dec 1;19(23):6461-72.
[4]. david m, sahay d, mege f, descotes f, leblanc r, ribeiro j, clézardin p, peyruchaud o. identification of heparin-binding egf-like growth factor (hb-egf) as a biomarker for lysophosphatidic acid receptor type 1 (lpa1) activation in human breast and prostate cancers. plos one. 2014 may 14;9(5):e97771.
KI16425 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29627 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |