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2,5-Dioxopyrrolidin-1-yl octanoate

2,5-Dioxopyrrolidin-1-yl octanoate structure

CAS No.: 14464-30-3

Chemical Name:: 2,5-Dioxopyrrolidin-1-yl octanoate

Synonyms: Eliglustat Impurity 11;Eliglustat intermediate 6;2,5-dioxopyrrolidin-1-yl octanoate;Octanoic acid-N-succinimidyl ester;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate

CBNumber:: CB9497580

Molecular Formula:: C12H19NO4

Molecular Weight:: 241.28

MDL Number:: MFCD00050404

MOL File:: 14464-30-3.mol

Last updated:2023-10-30 14:43:20

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2,5-Dioxopyrrolidin-1-yl octanoate Properties

Melting point	61-63 °C
Boiling point	333.2±25.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25

2,5-Dioxopyrrolidin-1-yl octanoate price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D487145	(2,5-Dioxopyrrolidin-1-yl)Octanoate	14464-30-3	250mg	$40	2021-12-16	Buy
Matrix Scientific	178726	Caprylic acid N-succinimidyl ester	14464-30-3	10g	$1156	2021-12-16	Buy
Matrix Scientific	178726	Caprylic acid N-succinimidyl ester	14464-30-3	25g	$1980	2021-12-16	Buy
Ambeed	A386850	2,5-Dioxopyrrolidin-1-yloctanoate 97%	14464-30-3	250mg	$10	2021-12-16	Buy
Ambeed	A386850	2,5-Dioxopyrrolidin-1-yloctanoate 97%	14464-30-3	1g	$17	2021-12-16	Buy

Product number	Packaging	Price	Buy
D487145	250mg	$40	Buy
178726	10g	$1156	Buy
178726	25g	$1980	Buy
A386850	250mg	$10	Buy
A386850	1g	$17	Buy

2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Uses,Production

Uses

(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Preparation

N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.
CAPRYLIC ACID N-SUCCINIMIDYL ESTER

2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dioxopyrrolidin-1-yl octanoate Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Hongxiong	+undefined18915499068	Suzhouhongxiong@163.com	China	120	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Excellent Biotech Co., Ltd.	58
career henan chemical co	58
Shanghai Gubang New Materail Technology Co. LTD	58
AFINE CHEMICALS LIMITED	58
LEAP CHEM CO., LTD.	58
Hongxiong	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
China National Standard Pharmaceutical Corporation Limited	58

View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-02-13	2,5-dioxopyrrolidin-1-yl octanoate 14464-30-3	US $900.00 / g	1g	98	500 Kg	R&D Scientific Inc.
	2020-01-09	CAPRYLIC ACID N-SUCCINIMIDYL ESTER 14464-30-3	US $2.00 / KG	1g	98%min	ask	Career Henan Chemical Co

2,5-dioxopyrrolidin-1-yl octanoate
14464-30-3
US $900.00 / g
98
R&D Scientific Inc.

CAPRYLIC ACID N-SUCCINIMIDYL ESTER
14464-30-3
US $2.00 / KG
98%min
Career Henan Chemical Co

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Caprylic acid-N-hydroxysuccinimide ester N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate Eliglustat intermediate 6 2,5-dioxopyrrolidin-1-yl octanoate 1-(Octanoyloxy)-2,5-pyrrolidinedione Octanoic acid-N-succinimidyl ester Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester Eliglustat Impurity 11 Octanoic acid N-hydroxy succinimide ester 14464-30-3