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Pinacidil

CAS No.
85371-64-8
Chemical Name:
Pinacidil
Synonyms
Hndac;Pinacidil;Pinacidil Hydrate;Pinacidil USP/EP/BP;Pinacidil monohydrate (Pinacidil hydrate);Pinacidil monohydrate (Synonyms: Pinacidil hydrate);(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine;Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate;(±)-N-Cyano-N’-4-pyridinyl-N’’-(1,2,2-trimethylpropyl)guanidine monohydrate;Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)
CBNumber:
CB9498330
Molecular Formula:
C13H21N5O
Molecular Weight:
263.35
MDL Number:
MFCD00242745
MOL File:
85371-64-8.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:15

Pinacidil Properties

Melting point 164-165°
storage temp. RT
solubility ethanol: 14 mg/mL
form solid
pka pKa 空 (Uncertain)
color white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference 85371-64-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7B0ZZH8P2W
ATC code C02DG01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  36
WGK Germany  3
Toxicity LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978)
NFPA 704
0
2 0

Pinacidil price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P154 Pinacidil monohydrate powder 85371-64-8 100mg $152 2024-03-01 Buy
Sigma-Aldrich P154 Pinacidil monohydrate powder 85371-64-8 1g $901 2024-03-01 Buy
Cayman Chemical 15416 Pinacidil (hydrate) ≥98% 85371-64-8 25mg $29 2024-03-01 Buy
Cayman Chemical 15416 Pinacidil (hydrate) ≥98% 85371-64-8 50mg $54 2024-03-01 Buy
Sigma-Aldrich P154 Pinacidil monohydrate powder 85371-64-8 500mg $603 2024-03-01 Buy
Product number Packaging Price Buy
P154 100mg $152 Buy
P154 1g $901 Buy
15416 25mg $29 Buy
15416 50mg $54 Buy
P154 500mg $603 Buy

Pinacidil Chemical Properties,Uses,Production

Description

Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical evidence suggests that its hypotensive effect may be attributed to potassium channel activation.

Originator

Leo (Denmark)

Uses

cardiac stimulant

Uses

Pinacidil monohydrate has been used:

  • in repolarization studies by infusing into left anterior descending artery (LAD)
  • to induce ATP-sensitive K+ (KATP) current in ventricular myocytes for electrophysiological studies
  • as a KATP opener to treat myocardial cells

Uses

Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent.

Definition

ChEBI: Pinacidil is an organic molecular entity.

brand name

Pindac (Leo).

Biochem/physiol Actions

Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.

References

1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17 2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Pharmacol. Exp. Therap., 275 681 3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5 4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796 5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428 6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7

100-48-1
53561-77-6
85371-64-8
Synthesis of Pinacidil from 4-Cyanopyridine and 1,2,2-TRIMETHYLPROPYLAMINE HYDROCHLORIDE

Pinacidil Preparation Products And Raw materials

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252 daisy@crovellbio.com China 5966 58
changzhou huayang technology co., ltd
+8615250961469 2571773637@qq.com China 9821 58
ZHEJIANG JIUZHOU CHEM CO., LTD
+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com China 20000 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58

View Lastest Price from Pinacidil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pinacidil monohydrate pictures 2023-03-06 Pinacidil monohydrate
85371-64-8
US $1.90 / KG 1KG 99% 10 ton Hebei Guanlang Biotechnology Co,.LTD
Pinacidil USP/EP/BP pictures 2021-08-07 Pinacidil USP/EP/BP
85371-64-8
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Pinacidil pictures 2020-05-12 Pinacidil
85371-64-8
US $0.00-0.00 / KG 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
  • Pinacidil pictures
  • Pinacidil
    85371-64-8
  • US $0.00-0.00 / KG
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd
(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine Pinacidil Hndac (±)-N-Cyano-N’-4-pyridinyl-N’’-(1,2,2-trimethylpropyl)guanidine monohydrate Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate Pinacidil Hydrate Pinacidil monohydrate (Synonyms: Pinacidil hydrate) Pinacidil monohydrate (Pinacidil hydrate) Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1) Pinacidil USP/EP/BP P1134,P-1134,Pinacidil monohydrate,inhibit,P 1134,Inhibitor,Potassium Channel,Pinacidil,KcsA 85371-64-8 85371-64-6 C13H19N5H2O INOCOR