(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- CAS No.
- 133812-16-5
- Chemical Name:
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- Synonyms
- Locostatin;(E/Z)-Locostatin;4-benzyl-3-crotonyl-2-oxazolidinone;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;Cell Sheet Migration Inhibitor, Locostatin;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-
- CBNumber:
- CB9499650
- Molecular Formula:
- C14H15NO3
- Molecular Weight:
- 245.27
- MDL Number:
- MFCD00278769
- MOL File:
- 133812-16-5.mol
- MSDS File:
- SDS
| Melting point | 84-88 °C(lit.) |
|---|---|
| Boiling point | 351.0±25.0 °C(Predicted) |
| Density | 1.205±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (60 mg/ml) |
| form | solid |
| pka | -1?+-.0.40(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64425 | Locostatin | 133812-16-5 | 10mg | $128.65 | 2024-03-01 | Buy |
| Alfa Aesar | J64425 | Locostatin | 133812-16-5 | 50mg | $390.65 | 2024-03-01 | Buy |
| Cayman Chemical | 29092 | (E/Z)-Locostatin | 133812-16-5 | 10mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 29092 | (E/Z)-Locostatin | 133812-16-5 | 100mg | $595 | 2024-03-01 | Buy |
| Cayman Chemical | 29092 | (E/Z)-Locostatin | 133812-16-5 | 5mg | $62 | 2024-03-01 | Buy |
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties,Uses,Production
Description
Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Uses
Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration
References
Zhu et al. (2005), A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration; Chem. Biol., 12 981 Beshir et al. (2011), Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket; For. Immunopathol. Dis. Therap. 2 47 Menoret et al. (2009), The oxazolidinone derivative locostatin induces cytokine appeasement; J. Immunol. 183 7489 Ma et al. (2019), Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice; Dig. Dis. Sci. 64 2570 Mc Henry et al. (2008), Raf kinase inhibitor protein positively regulates cell-cell adhesion; J. Cell Biochem. 103 972
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5738 | 55 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16687 | 50 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Shijiazhuang Yesheng Chemical Technology Co., Ltd | 0311-68030586 18031147013 | yeshengchemical@163.com | China | 2977 | 58 |
| Shanghai Pingguo Pharmaceutical Co., Ltd. | 021-20432229 | 2412110556@qq.com | China | 6018 | 55 |
| Suzhou Kangrun Pharmaceutical Co., Ltd. | 0512-63912376 18962555590 | China | 973 | 58 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
View Lastest Price from (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-02 | (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
133812-16-5
|
US $1.00 / g | 1g | 99% | 200g | Career Henan Chemical Co |
-
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
133812-16-5
- US $1.00 / g
- 99%
- Career Henan Chemical Co