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Everolimus

description
Everolimus
Everolimus
CAS No.
159351-69-6
Chemical Name:
Everolimus
Synonyms
SDZRAD;RAD-001;Certica;Certican;Afinitor;Zortress;Everolimus;CERTICAN(R);EveroliMus API;Everolimus, >=98%
CBNumber:
CB9502411
Molecular Formula:
C53H83NO14
Formula Weight:
958.232
MOL File:
159351-69-6.mol

Everolimus Properties

Melting point:
NA
Flash point:
2℃
storage temp. 
−20°C
Water Solubility 
Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability:
Hygroscopic
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,F
Risk Statements  48/25-36-20/21/22-11
Safety Statements  45-36/37-26-16
RIDADR  UN 1648 3 / PGII
WGK Germany  2
10
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P314 Get medical advice/attention if you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Everolimus price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E-068 Everolimus solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 159351-69-6 068-1ml $201 2017-11-08 Buy
Alfa Aesar J60139 Everolimus 159351-69-6 10mg $230 2017-11-08 Buy
Alfa Aesar J60139 Everolimus 159351-69-6 5mg $156 2017-11-08 Buy
Cayman Chemical 11597 Everolimus ≥98% 159351-69-6 5mg $65 2017-11-08 Buy
Cayman Chemical 11597 Everolimus ≥98% 159351-69-6 10mg $98 2017-11-08 Buy

Everolimus Chemical Properties,Uses,Production

description

Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.
In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).

Chemical Properties

Off White Solid

Uses

Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation

Uses

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM

Uses

Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.

Uses

Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

Definition

ChEBI: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.

Everolimus Preparation Products And Raw materials

Raw materials

Preparation Products


Everolimus Suppliers

Global( 196)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 9974 55
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4801 58
EASON Chemical Co., LIMITED 15157289797 13566878689
0576-88860891 info@seasonsbio.com China 66 58
Suzhou Unite pharmTech Co., Ltd , +86-013222993784 +86-512-82177310
+86-512-82177310 +86-512-62575043 sales@unite-pharm.com China 84 56
Taizhou KEDE Chemical Co., Ltd 0576-84613060 13093829633 13857631286
0576-84613060 sales@kedechemical.com China 291 60
Shanghai Linka Biotechnology Co., Ltd. 15901858719 QQ2126935757
021-61155234 sales@linkachem.com China 324 55
Wuhan Biocar Bio-Pharm Co., Ltd. 13343428090
86-027-87050469 sales@biocar.cn China 1551 50
BOC Sciences
info@bocsci.com United States 9930 65
Shanghai Lollane Biological Technology Co.,Ltd. +86-21-61128122
+86-21-61128122 sales@lollanechem.com China 1543 55

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