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Everolimus

description

CAS No. 159351-69-6
Chemical Name: Everolimus
Synonyms: SDZRAD;RAD-001;Certica;Afinitor;Certican;Zortress;Everolimus;CERTICAN(R);EveroliMus API;Everolimus, >=98%
CBNumber: CB9502411
Molecular Formula: C53H83NO14
Formula Weight: 958.232
MOL File: 159351-69-6.mol
Everolimus Property
Melting point : NA
Fp : 2℃
storage temp. : −20°C
Water Solubility : Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability:: Hygroscopic
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T,Xn,F
Risk Statements : 48/25-36-20/21/22-11
Safety Statements : 45-36/37-26-16
RIDADR : UN 1648 3 / PGII
WGK Germany : 2
F : 10
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P314 Get medical advice/attention if you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Everolimus Chemical Properties,Usage,Production

description
Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.
In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).
Chemical Properties
Off White Solid
Uses
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation
Uses
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM
Uses
Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
Uses
Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.
Definition
ChEBI: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.
Everolimus Preparation Products And Raw materials
Raw materials
Preparation Products
Everolimus Suppliers      Global( 185)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4846 58
EASON Chemical Co., LIMITED 15157289797 13566878689
0576-88860891 info@seasonsbio.com China 56 58
Suzhou Unite pharmTech Co., Ltd , +86-013222993784 +86-512-82177310
+86-512-82177310 +86-512-62575043 sales@unite-pharm.com China 85 56
Hunan Cangood Medical Technology Ltd. 400-026-9899, +86-731-83862081, +86-18974920699
+86-731-86905278 info@cangood.cn China 72 50
Taizhou KEDE Chemical Co., Ltd 0576-84613060 13093829633 13857631286
0576-84613060 sales@kedechemical.com China 291 60
Shanghai Linka Biotechnology Co., Ltd. 15901858719 QQ2126935757
021-61155234 sales@linkachem.com China 283 55
BrightGene Bio-medical Technology Co., Ltd. +86 (512) 62551767
+86 (512) 62551799 richardchan@bright-gene.com China 38 70
Wuhan Biocar Bio-Pharm Co., Ltd. 17764003753
86-027-87050469 sales@biocar.cn China 1300 50
Shanghai Boyle Chemical Co., Ltd. 86-21-50180596
86-21-57758967 sales@boylechem.com China 2790 55
 
159351-69-6(Everolimus)Related Search:
Everolimus-d4 Ethyl1-butyl-2-piperidinecarbxylate Ethyl pipecolinate DL-PIPECOLINIC ACID TETRAHYDRATE 2-(dibutylamino)acetic acid 1-ACETYL-2-PIPERIDINECARBOXYLIC ACID 1-methyl-piperidine-2-carboxylicacidmethylester N,N-DI-N-PROPYL-L-ALANINE 2-(TETRAHYDRO-PYRAN-2-YL)-ETHYLAMINE Rapamycin Everolimus 1-ETHYL-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE D(+)-Pipecolinic acid 1-(2-methylpiperidin-1-yl)acetone Ethyl 1-methylpipecolinate H-HOMOPRO-OME HCL 1-piperidinoacetone
159351-69-6 42-O-(2-Hydroxyethyl)-rapamycin Certica RAD-001 SDZRAD Rapamycin, 42-O-(2-hydroxyethyl)- Everolimus C53H83NO14 Certican All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals CERTICAN(R) EveroliMus(RAD-001) (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-Methoxycyclohexyl]propan-2-yl]-19,30-diMethoxy-15,17,21,23,29,35-hexaMethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,2 Afinitor Zortress Inhibitor Antineoplastic protein kinase inhibitors mTOR inhibitor EveroliMus API Certican, Zortress, Afinitor Anti-cancer&immunity PI3K/Akt/mTOR 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv Everolimus solution Everolimus, >=98% Akt mTOR PI3K
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