Everolimus
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Everolimus Properties
- Melting point:
- NA
- Flash point:
- 2℃
- storage temp.
- −20°C
- Water Solubility
- Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
- Stability:
- Hygroscopic
SAFETY
- Risk and Safety Statements
- Hazard and Precautionary Statements (GHS)
| Hazard Codes | T,Xn,F | ||
|---|---|---|---|
| Risk Statements | 48/25-36-20/21/22-11 | ||
| Safety Statements | 45-36/37-26-16 | ||
| RIDADR | UN 1648 3 / PGII | ||
| WGK Germany | 2 |
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| F | 10 |
| Symbol(GHS): |
  
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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| Precautionary statements: |
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Everolimus price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E-068 | Everolimus solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material | 159351-69-6 | 068-1ml | $201 | 2017-11-08 | Buy |
| Alfa Aesar | J60139 | Everolimus | 159351-69-6 | 10mg | $230 | 2017-11-08 | Buy |
| Alfa Aesar | J60139 | Everolimus | 159351-69-6 | 5mg | $156 | 2017-11-08 | Buy |
| Cayman Chemical | 11597 | Everolimus ≥98% | 159351-69-6 | 5mg | $65 | 2017-11-08 | Buy |
| Cayman Chemical | 11597 | Everolimus ≥98% | 159351-69-6 | 10mg | $98 | 2017-11-08 | Buy |
Everolimus Chemical Properties,Uses,Production
description
Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).
Chemical Properties
Off White SolidUses
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferationUses
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nMUses
Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.Uses
Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.Definition
ChEBI: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.Everolimus Preparation Products And Raw materials
Raw materials
Preparation Products
Everolimus Suppliers
Global( 212)Suppliers
| Supplier | Tel | Fax | Country | ProdList | Advantage | |
|---|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86 (0)571-855 867 18 |
+86 (0)571-858 647 95 | sales@capotchem.com | China | 19953 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd. | +86-10-60279497 +86(0)15646567669 |
+86-10-60279497 | sales01@cooperate-pharm.com | CHINA | 1214 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 |
0371-55170693 | info@tianfuchem.com | CHINA | 20809 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 E-mail：sales03@shyrchem.com |
+86-21-34979012 | sales03@shyrchem.com | CHINA | 660 | 60 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682; +8618874586545 |
bruce@xrdchem.cn | CHINA | 514 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +86 21 5161 9050/ 5187 7795 |
+86 21 5161 9052/ 5187 7796 | ivan@atkchemical.com | CHINA | 10714 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-66771943；0411-66771942 |
0411-66771945 | sales@meilune.com | China | 4411 | 58 |
| EASON Chemical Co., LIMITED | 15157289797 13566878689 |
0576-88860891 | info@seasonsbio.com | China | 66 | 58 |
| Taizhou KEDE Chemical Co., Ltd | 0576-84613060 13093829633 13857631286 |
0576-84613060 | sales@kedechemical.com | China | 291 | 60 |
| Shanghai Linka Biotechnology Co., Ltd. | 15901858719 QQ2126935757 |
021-61155234 | sales@linkachem.com | China | 285 | 55 |
View Lastest Price from Everolimus manufacturers
| Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2018-03-29 |
Everolimus 159351-69-6 159351-69-6 |
US $10.00 / KG | 10G | 99% | 10mt | Hubei XinRunde Chemical Co., Ltd |
159351-69-6(Everolimus)Related Search:
Everolimus-d4 Ethyl1-butyl-2-piperidinecarbxylate Ethyl pipecolinate DL-PIPECOLINIC ACID TETRAHYDRATE 2-(dibutylamino)acetic acid 1-ACETYL-2-PIPERIDINECARBOXYLIC ACID 1-methyl-piperidine-2-carboxylicacidmethylester N,N-DI-N-PROPYL-L-ALANINE 2-(TETRAHYDRO-PYRAN-2-YL)-ETHYLAMINE Rapamycin Everolimus 1-ETHYL-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE D(+)-Pipecolinic acid 1-(2-methylpiperidin-1-yl)acetone Ethyl 1-methylpipecolinate H-HOMOPRO-OME HCL 1-piperidinoacetone
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