Everolimus

Melting point : NA

Fp : 2℃

storage temp. : −20°C

Water Solubility : Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.

Stability:: Hygroscopic

description Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. Everolimus is a biological therapy treatment for Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane Advanced kidney cancer that has come back either during or after treatment. Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease). Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).

Chemical Properties Off White Solid

Uses Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation

Uses Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM

Uses Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.

Uses Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

Definition ChEBI: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.

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Capot Chemical Co.,Ltd.	+86 (0)571-855 867 18	+86 (0)571-858 647 95	sales@capotchem.com	China	19954	60
Dalian Meilun Biotech Co., Ltd.	0411-66771943；0411-66771942	0411-66771945	sales@meilune.com	China	4846	58
EASON Chemical Co., LIMITED	15157289797 13566878689	0576-88860891	info@seasonsbio.com	China	56	58
Suzhou Unite pharmTech Co., Ltd ,	+86-013222993784 +86-512-82177310	+86-512-82177310 +86-512-62575043	sales@unite-pharm.com	China	85	56
Hunan Cangood Medical Technology Ltd.	400-026-9899, +86-731-83862081, +86-18974920699	+86-731-86905278	info@cangood.cn	China	72	50
Taizhou KEDE Chemical Co., Ltd	0576-84613060 13093829633 13857631286	0576-84613060	sales@kedechemical.com	China	291	60
Shanghai Linka Biotechnology Co., Ltd.	15901858719 QQ2126935757	021-61155234	sales@linkachem.com	China	283	55
BrightGene Bio-medical Technology Co., Ltd.	+86 (512) 62551767	+86 (512) 62551799	richardchan@bright-gene.com	China	38	70
Wuhan Biocar Bio-Pharm Co., Ltd.	17764003753	86-027-87050469	sales@biocar.cn	China	1300	50
Shanghai Boyle Chemical Co., Ltd.	86-21-50180596	86-21-57758967	sales@boylechem.com	China	2790	55