CHK2 INHIBITOR II
- CAS No.
- 516480-79-8
- Chemical Name:
- CHK2 INHIBITOR II
- Synonyms
- C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;C 3742 BML-277;BML-277 (C 3742);Chk2 Inhibitor II hydrate;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II (BML-277)
- CBNumber:
- CB9503256
- Molecular Formula:
- C20H14ClN3O2
- Molecular Weight:
- 363.8
- MDL Number:
- MFCD08276917
- MOL File:
- 516480-79-8.mol
- MSDS File:
- SDS
| Boiling point | 637.1±63.0 °C(Predicted) |
|---|---|
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | solid |
| pka | 10.40±0.10(Predicted) |
| color | tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
CHK2 INHIBITOR II price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 220486 | Chk2 Inhibitor II | 516480-79-8 | 1mg | $172 | 2024-03-01 | Buy |
| Sigma-Aldrich | 220491 | InSolution? Chk2 Inhibitor II | 516480-79-8 | 5mg | $280 | 2023-01-07 | Buy |
| Cayman Chemical | 17552 | Chk2 Inhibitor II ≥98% | 516480-79-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17552 | Chk2 Inhibitor II ≥98% | 516480-79-8 | 5mg | $93 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3742 | Chk2 Inhibitor II hydrate ≥98% (HPLC) | 516480-79-8 | 5mg | $220 | 2024-03-01 | Buy |
CHK2 INHIBITOR II Chemical Properties,Uses,Production
Description
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
Uses
Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
References
1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873 2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819
CHK2 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from CHK2 INHIBITOR II manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | CHK2 INHIBITOR II
516480-79-8
|
US $1.00 / KG | 1KG | 95%~99% | per week:100kg | Career Henan Chemical Co |
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- CHK2 INHIBITOR II
516480-79-8
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co