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NH125

CAS No.
278603-08-0
Chemical Name:
NH125
Synonyms
NH125 USP/EP/BP;EEF-2 KINASE INHIBITOR;eEF-2 Kinase Inhibitor, NH125;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
CBNumber:
CB9503988
Molecular Formula:
C27H45N2.I
Molecular Weight:
524.567
MDL Number:
MFCD07370143
MOL File:
278603-08-0.mol
Last updated:2023-06-30 15:45:59

NH125 Properties

Melting point 88.2-94.9 °C
storage temp. -20°C
solubility DMSO: 20 mg/mL
form solid
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

NH125 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N2162 NH125 ≥98% (HPLC), solid 278603-08-0 5mg $173.6 2024-03-01 Buy
Cayman Chemical 10011250 NH125 ≥95% 278603-08-0 1mg $40 2024-03-01 Buy
Cayman Chemical 10011250 NH125 ≥95% 278603-08-0 5mg $118 2024-03-01 Buy
Cayman Chemical 10011250 NH125 ≥95% 278603-08-0 25mg $341 2024-03-01 Buy
Sigma-Aldrich N2162 NH125 ≥98% (HPLC), solid 278603-08-0 25mg $1630 2023-01-07 Buy
Product number Packaging Price Buy
N2162 5mg $173.6 Buy
10011250 1mg $40 Buy
10011250 5mg $118 Buy
10011250 25mg $341 Buy
N2162 25mg $1630 Buy

NH125 Chemical Properties,Uses,Production

Uses

NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.

Biological Activity

Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

storage

Desiccate at -20°C

References

[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68.

NH125 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 61)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide eEF-2 Kinase Inhibitor, NH125 eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem EEF-2 KINASE INHIBITOR NH125 USP/EP/BP 3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK 278603-08-0 C27H45IN2 Inhibitors