TH 257
- CAS No.
- 2244678-29-1
- Chemical Name:
- TH 257
- Synonyms
- TH 257;TH-257, 10 mM in DMSO;N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide;LIM Kinase (LIMK),LIMKs,Inhibitor,TH-257,inhibit,TH257;Benzamide, N-butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)-
- CBNumber:
- CB95476799
- Molecular Formula:
- C24H26N2O3S
- Molecular Weight:
- 422.54
- MDL Number:
- MOL File:
- 2244678-29-1.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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TH 257 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0087663 | TH-257 98.91% | 2244678-29-1 | 10mg | $113 | 2021-12-16 | Buy |
Axon Medchem | Axon2973 | TH257 99% | 2244678-29-1 | 50mg | $368.5 | 2021-12-16 | Buy |
ChemScene | CS-0087663 | TH-257 98.91% | 2244678-29-1 | 5mg | $73 | 2021-12-16 | Buy |
Ambeed | A1193405 | N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide 98+% | 2244678-29-1 | 5mg | $93 | 2021-12-16 | Buy |
CSNpharm | CSN24750 | TH257 | 2244678-29-1 | 1mg | $27 | 2021-12-16 | Buy |
TH 257 Chemical Properties,Uses,Production
Biological Activity
TH-257 is a potent, type III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) th at targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 μM. TH-263 is a structure analog and the recommended negative control for TH-257. For characterization details of TH-257, please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.
TH-263 is the negative control for the active probe, TH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
storage
Store at +4°C
TH 257 Preparation Products And Raw materials
Raw materials
Preparation Products
TH 257 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4569 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9805 | 58 |