BMS-1001
- CAS No.
- 2113650-04-5
- Chemical Name:
- BMS-1001
- Synonyms
- BMS-1001 hydrochloride, 10 mM in DMSO;Inhibitor,BMS 1001,inhibit,ICB,toxicity,BMS1001,immune,checkpoint,BMS 1001 hydrochloride,BMS-1001,BMS1001 hydrochloride,low;(2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride;BMS-1001 hydrochloride (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5- methylbenzyl)-D-serine hydrochloride
- CBNumber:
- CB95853026
- Molecular Formula:
- C35H35ClN2O7
- Molecular Weight:
- 631.12
- MDL Number:
- MFCD32690091
- MOL File:
- 2113650-04-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BMS-1001 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27891 | BMS-1001 (hydrochloride) | 2113650-04-5 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 27891 | BMS-1001 (hydrochloride) | 2113650-04-5 | 10mg | $632 | 2024-03-01 | Buy |
| Cayman Chemical | 27891 | BMS-1001 (hydrochloride) | 2113650-04-5 | 5mg | $356 | 2024-03-01 | Buy |
| ChemScene | CS-0078503 | BMS-1001hydrochloride 98.46% | 2113650-04-5 | 5mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0078503 | BMS-1001hydrochloride 98.46% | 2113650-04-5 | 10mg | $355 | 2021-12-16 | Buy |
BMS-1001 Chemical Properties,Uses,Production
Description
BMS-1001 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 2.25 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.
Uses
BMS-1001 is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 exhibits low-toxicity in cells. The IC50 value of BMS-1001 in a homogeneous time-resolved fluorescence (HTRF) binding assay is 2.25 nM[1][2].
References
[1] Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181. DOI:10.18632/oncotarget.20050
[2] Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. DOI:10.1021/acs.jmedchem.7b00293
BMS-1001 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-1001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2991 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |