ChemicalBook >> CAS DataBase List >>Nebivolol hydrochloride
Nebivolol hydrochloride
- CAS No.
- 152520-56-4
- Chemical Name:
- Nebivolol hydrochloride
- Synonyms
- D06622;CS-496;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
- CBNumber:
- CB9649567
- Molecular Formula:
- C22H26ClF2NO4
- Molecular Weight:
- 441.9
- MDL Number:
- MFCD07357273
- MOL File:
- 152520-56-4.mol
Last updated:2024-03-16 07:03:48
| Melting point | 220-222°C |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,6432 |
| FDA UNII | JGS34J7L9I |
Nebivolol hydrochloride price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N1915 | Nebivolol hydrochloride ≥98% (HPLC) | 152520-56-4 | 10mg | $82.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1457833 | Nebivolol hydrochloride United States Pharmacopeia (USP) Reference Standard | 152520-56-4 | 150mg | $2590 | 2024-03-01 | Buy |
| TCI Chemical | N0954 | Nebivolol Hydrochloride >98.0%(HPLC) | 152520-56-4 | 20mg | $71 | 2024-03-01 | Buy |
| TCI Chemical | N0954 | Nebivolol Hydrochloride >98.0%(HPLC) | 152520-56-4 | 100mg | $212 | 2024-03-01 | Buy |
| Cayman Chemical | 23660 | Nebivolol (hydrochloride) ≥98% | 152520-56-4 | 5mg | $37 | 2024-03-01 | Buy |
Nebivolol hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Powder
Uses
A ?-Adrenergic blocker. Used as an antihypertensive
Uses
Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.
Uses
Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM
Definition
ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.
Biological Activity
Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .
Biochem/physiol Actions
Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.
storage
Desiccate at RT
Nebivolol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 396)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Qiangshan New Material Co.,Ltd. | +86-13951653990 +86-13951653990 | jjx35259720@hotmail.com | China | 27 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Nebivolol hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Nebivolol hydrochloride
152520-56-4
|
US $35.00-25.00 / kg | 1kg | 99.8% | 200tons/year | Sigma Audley | |
 |
2023-11-27 | Nebivolol hydrochloride
152520-56-4
|
US $0.00 / KG | 1KG | 99% | 20 TONS | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2023-07-25 | Nebivolol hydrochloride
152520-56-4
|
US $100.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD |
-
- Nebivolol hydrochloride
152520-56-4
- US $35.00-25.00 / kg
- 99.8%
- Sigma Audley
-
- Nebivolol hydrochloride
152520-56-4
- US $0.00 / KG
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
-
- Nebivolol hydrochloride
152520-56-4
- US $100.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
152520-56-4(Nebivolol hydrochloride)Related Search:
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Narbivolol
rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
Nebivolol hydrochloride, >=98%
RAC NEBIVOLOL, HYDROCHLORIDE
a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
Lobivon
Nebilet
Nebilox
R-67555
NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)
a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
Nebivolol hydrochloride
NEBIVOLOL HC
a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
D06622
Nebivolol hydrochloride (usan)
(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Nebivolol (Bystolic)
Nebivalate HCl
Bystolic
2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)-
R 065824 hydrochloride
CS-496
(169293-50-9) nebivolol hydrochloride
Nebivolol hydrochloride, 98%, a selective β1 antagonist
NebivololHydrochloride>
Nebivolol reference substance
Nebivolol hydrochloride USP/EP/BP
Nebivolol hydrochlorider
Nebivolol hydrochloride Impurities
Nebivolo
Nebivolol Hcl- IP
(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Nebivolol HCl (R 065824)
R-Nebivolol D4 HCl
Nebivolol HydrochlorideQ: What is
Nebivolol Hydrochloride Q: What is the CAS Number of
Nebivolol Hydrochloride Q: What is the storage condition of
Nebivolol Hydrochloride
TIANFU CHEM--Nebivolol hydrochloride
Nebivolol Hydrochloride (1457833)
Nebivolol hydrochloride salt
2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α'R,2R,2'S)-rel-
(αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-methanol hydrochloride (1:1)
Nebivolol hydrochloride (R-65824)
152520-56-4
C22H26ClF2NO4
C22H25F2NO4HCl
C22H25F2NO4ClH
C22H23O4F2NHCL
R-67145
API
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
152520-56-4