TIZOXANIDE
- CAS No.
- 173903-47-4
- Chemical Name:
- TIZOXANIDE
- Synonyms
- TIZ;4-ABAH;NSC640;NSC 640;NSC-640;NSC 697856;TIZOXANIDE;Tizoxanide, >98%;Desacetyl-nitazoxanide;Nitazoxanide Desacetyl Impurity
- CBNumber:
- CB9649941
- Molecular Formula:
- C10H7N3O4S
- Molecular Weight:
- 265.25
- MDL Number:
- MFCD07484970
- MOL File:
- 173903-47-4.mol
- MSDS File:
- SDS
| Melting point | 279-281°(dec) |
|---|---|
| Density | 1.644±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 6.70±0.50(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | 15KFG88UOJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H335-H319 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| HS Code | 2934.10.1000 | |||||||||
| NFPA 704 |
|
TIZOXANIDE price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3862 | Tizoxanide | 173903-47-4 | 25MG | $125 | 2024-03-01 | Buy |
| TCI Chemical | T3862 | Tizoxanide | 173903-47-4 | 100MG | $339 | 2024-03-01 | Buy |
| Cayman Chemical | 13693 | Tizoxanide ≥95% | 173903-47-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 13693 | Tizoxanide ≥95% | 173903-47-4 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 13693 | Tizoxanide ≥95% | 173903-47-4 | 10mg | $214 | 2024-03-01 | Buy |
TIZOXANIDE Chemical Properties,Uses,Production
Description
Tizoxanide is an active metabolite of the antiparasitic nitazoxanide . Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 μg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).
Chemical Properties
Light Yellow Powder
Uses
A metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.
Uses
A metabolite of Nitazoxanide; a potent inhibitor of hepatitis B virus and hepatitis C virus.
Definition
ChEBI: Desacetyl-nitazoxanide is a member of salicylamides.
in vitro
previous study found that tizoxanide showed potent inhibition of both hbv and hcv replication. tizoxanide also exhibited selective inhibition of intracellular hbv replication and extracellular virus production by 2.2.15 cells. tizoxanide could selectively reduce intracellular hcv replication in ava5 cells. moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (ifnα), or an ns5b (hcv polymerase) inhibitor, 2′-c-methyl cytidine, resulted in synergistic interactions against hcv replication. in addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for ava5 cells [1].
in vivo
animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].
IC 50
0.17 to 0.21 μm for civs
References
[1] korba be,montero ab,farrar k,gaye k,mukerjee s,ayers ms,rossignol jf. nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis b virus and hepatitis c virus replication. antiviral res.2008 jan;77(1):56-63.
[2] gargala g,delaunay a,li x,brasseur p,favennec l,ballet jj. efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against cryptosporidium parvum development in sporozoite-infected hct-8 enterocytic cells. j antimicrob chemother.2000 jul;46(1):57-60.
TIZOXANIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from TIZOXANIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Tizoxanide
173903-47-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Tizoxanide
173903-47-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-09-06 | TIZOXANIDE
173903-47-4
|
US $1.00 / KG | 1KG | 95%~99% | per week:100kg | Career Henan Chemical Co |
-
- Tizoxanide
173903-47-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Tizoxanide
173903-47-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- TIZOXANIDE
173903-47-4
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co