(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
- CAS No.
- 169675-09-6
- Chemical Name:
- (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
- Synonyms
- RO 60-0175 FUMARATE;Ro 600175 fumarate,Ro 60 0175 fumarate;(S)-1-(6-Chloro-5-fluoro-1H-indol-1-yl)propan-2-amine fumarate;(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate;(S)-2-(Chloro-5-fluoro-indol-L-yl)-1-methylethylamine fumarate;(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE;(alpha-S)-6-Chloro-5-fluoro-alpha-methyl-(1H)-indole-1-ethaneaminefumarate;1H-Indole-1-ethanaMine, 6-chloro-5-fluoro-a-Methyl-, (aS)-, (2E)-2-butenedioate;1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (S)-, (E)-2-butenedioate (1:1);1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (alphas)-, (2E)-2-butenedioate (1:1)
- CBNumber:
- CB9664058
- Molecular Formula:
- C15H16ClFN2O4
- Molecular Weight:
- 342.75
- MDL Number:
- MFCD06798313
- MOL File:
- 169675-09-6.mol
| storage temp. | Desiccate at RT |
|---|---|
| solubility | Soluble to 5 mM in water and to 20 mM in DMSO |
| form | Powder |
| FDA UNII | YQP8J4N96A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29520 | Ro 60-0175 | 169675-09-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29520 | Ro 60-0175 | 169675-09-6 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 29520 | Ro 60-0175 | 169675-09-6 | 10mg | $138 | 2021-12-16 | Buy |
| Tocris | 1854 | Ro60-0175fumarate ≥98%(HPLC) | 169675-09-6 | 10 | $159 | 2021-12-16 | Buy |
| Tocris | 1854 | Ro60-0175fumarate ≥98%(HPLC) | 169675-09-6 | 50 | $658 | 2021-12-16 | Buy |
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Chemical Properties,Uses,Production
Description
Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = ≥1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, α1-, α2-, and β1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and μ-, δ-, and κ-opioid receptors (IC50s = >1,000 nM), but does bind to β2-adrenergic receptors (IC50 = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 or the 5-HT2A antagonist MDL 100,907 (volinanserin; ).
Uses
Ro 60-0175 fumarate is a potent and selective SR-2 agonist.
Biological Activity
Potent, selective 5-HT 2 receptor agonist; shows selectivity for the 5-HT 2C subtype (pK i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT 2C , 2A , 1A , 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .
storage
Desiccate at RT
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Preparation Products And Raw materials
Raw materials
Preparation Products
(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Anhua Biotechnology Co., Ltd. | 021-61263375 18168859245 | China | 5958 | 58 | |
| Wuxi maimo topp biotechnology co., LTD | 13771048682 | alice@mimotopes.cn | China | 5854 | 58 |