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Dihydrostreptomycin

Dihydrostreptomycin structure

CAS No.: 128-46-1

Chemical Name:: Dihydrostreptomycin

Synonyms: DHSM;dhms;abiocine;vibriomycin;DIHYDROSTREPTOMYCIN;dihydro-streptomyci;DihydroestreptoMycin Sulfate;Benzimidazole, 2-cyanomethyl;dihydrostreptomycine sulphate;Dihydrostreptomycin USP/EP/BP

CBNumber:: CB9665040

Molecular Formula:: C21H41N7O12

Molecular Weight:: 583.59

MDL Number:: MFCD00084778

MOL File:: 128-46-1.mol

MSDS File:: SDS

Last updated:2024-03-16 15:39:10

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Dihydrostreptomycin Properties

Melting point	>300 °C
Boiling point	641.09°C (rough estimate)
Density	1.3963 (rough estimate)
refractive index	1.6800 (estimate)
pka	pKa 7.8 (Uncertain)
FDA 21 CFR	556.200
FDA UNII	P2I6R8W6UA
ATC code	S01AA15

Dihydrostreptomycin price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	D8035	Dihydrostreptomycin	128-46-1	100g	$72	2021-12-16	Buy
Usbiological	257286	Dihydrostreptomycin	128-46-1	50g	$470	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0014251	DIHYDROSTREPTOMYCIN 95.00%	128-46-1	1G	$1358.28	2021-12-16	Buy

Product number	Packaging	Price	Buy
D8035	100g	$72	Buy
257286	50g	$470	Buy
CHM0014251	1G	$1358.28	Buy

Dihydrostreptomycin Chemical Properties,Uses,Production

Description

Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.

Originator

Dihydrostrepto,MSD ,US,1948

Uses

Antibacterial.

Definition

ChEBI: Dihydrostreptomycin is a member of streptomycins.

Manufacturing Process

Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).

brand name

Abocillin;Biostrep;Complexobiotico;Diapenin 3;Diapenin balsamico;Diarrestival;Didromycin;Didrothenate;Dihydrocidan sulfato;Dihydrostreptofar;Diidro-pantostrept;Distreptopab;Dreiciclina balsamica;Dst;Entera-strept;Estreptoluy;Estreptosirup;Helle-strep-forte;Hp 48;Mastigun;Mixtencillin;Retromyopen;Rocopenstrep;Sanstrepto;Solmycin;Solvo-strept;Streptoduocin;Veticar;Veycil-as.

Therapeutic Function

Antibiotic

World Health Organization (WHO)

Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.

Safety Profile

Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx

Dihydrostreptomycin Preparation Products And Raw materials

Raw materials

Hydrogen Streptomycin sulfate

Preparation Products

Dihydrostreptomycin Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3632	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from Dihydrostreptomycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-20	Dihydrostreptomycin 128-46-1	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
2021-06-23	Dihydrostreptomycin USP/EP/BP 128-46-1	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2019-12-26	Dihydrostreptomycin 128-46-1	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

Dihydrostreptomycin
128-46-1
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Dihydrostreptomycin USP/EP/BP
128-46-1
US $1.10 / g
99.9%
Dideu Industries Group Limited

Dihydrostreptomycin
128-46-1
US $1.00 / g
≥98%
Career Henan Chemical Co

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DIHYDROSTREPTOMYCIN Dihydrostreptomycin (base and/or unspecified salts) 2-[(1S,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine Acetonitrile, 2-benzimidazolyl- Benzimidazole, 2-cyanomethyl 4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-hydroxymethyl-α-L-lyxofuranosyl]-N,N'-bis(aminoiminomethyl)-D-streptamine DHSM DihydroestreptoMycin Sulfate 2)-O-5-deoxy-3-C-(hydroxyMethyl)-a-L-lyxofuranosyl-(1® 4)-N1,N3-bis(aMinoiMinoMethyl)- D-StreptaMine,O-2-deoxy-2-(MethylaMino)-a-L-glucopyranosyl-(1® dihydrostreptomycine sulphate DihydrostreptomycineSulphateSterileUsp26 D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)- abiocine dhms dihydro-streptomyci vibriomycin 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)- Dihydrostreptomycin USP/EP/BP 128-46-1 C21H41N7O12