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tert-Butyl carbazate

tert-Butyl carbazate structure

CAS No.: 870-46-2

Chemical Name:: tert-Butyl carbazate

Synonyms: tert-butyl hydrazinecarboxylate;carbazate;BOC-NHNH2;BOC-HYDRAZINE;T-BUTYLCARBAZATE;tert-Butyl N-aminocarbamate;HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER;BOC-HYDRAZIDE;TERT-BUTOXYCARBONYL HYDRAZIDE;T-BOC-HYDRAZIDE

CBNumber:: CB9686391

Molecular Formula:: C5H12N2O2

Molecular Weight:: 132.16

MDL Number:: MFCD00007593

MOL File:: 870-46-2.mol

MSDS File:: SDS

Last updated:2024-04-23 17:50:46

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tert-Butyl carbazate Properties

Melting point	39-42 °C (lit.)
Boiling point	63-65 °C/0.1 mmHg (lit.)
Density	1.02
refractive index	1.4496 (estimate)
Flash point	197 °F
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in ethanol and methanol.
pka	10.74±0.20(Predicted)
form	Crystalline Lumps
color	White to slightly yellow
Sensitive	Moisture Sensitive
BRN	1756967
InChIKey	DKACXUFSLUYRFU-UHFFFAOYSA-N
CAS DataBase Reference	870-46-2(CAS DataBase Reference)
EPA Substance Registry System	Hydrazinecarboxylic acid, 1,1-dimethylethyl ester (870-46-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Danger

Hazard statements

H228

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

1325

WGK Germany

TSCA

Yes

HazardClass

4.1

PackingGroup

III

HS Code

29280090

NFPA 704

	2
3		0

tert-Butyl carbazate price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B91005	tert-Butyl carbazate 98%	870-46-2	5g	$38.5	2024-03-01	Buy
Sigma-Aldrich	B91005	tert-Butyl carbazate 98%	870-46-2	25g	$79.4	2024-03-01	Buy
Alfa Aesar	A12383	tert-Butyl carbazate, 98+%	870-46-2	25g	$74.2	2024-03-01	Buy
Alfa Aesar	A12383	tert-Butyl carbazate, 98+%	870-46-2	100g	$126.65	2024-03-01	Buy
Sigma-Aldrich	B91005	tert-Butyl carbazate 98%	870-46-2	100g	$148	2024-03-01	Buy

Product number	Packaging	Price	Buy
B91005	5g	$38.5	Buy
B91005	25g	$79.4	Buy
A12383	25g	$74.2	Buy
A12383	100g	$126.65	Buy
B91005	100g	$148	Buy

tert-Butyl carbazate Chemical Properties,Uses,Production

Chemical Properties

White to pale yellow lumps

Uses

Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection.

Uses

tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018
Chemical and Pharmaceutical Bulletin, 18, p. 217, 1970 DOI: 10.1248/cpb.18.217

Purification Methods

Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.]

tert-Butyl carbazate synthesis

Synthesis of tert-Butyl carbazate from Di-tert-butyl dicarbonate

tert-Butyl carbazate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Di-tert-butyl dicarbonate Hydrazine hydrate Isopropyl alcohol N-Boc-L-Histidine

N,N'-Di-tert-butoxycarbonyl-L-histidine

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Preparation Products

PYRIDIN-2-YLMETHYL-HYDRAZINE PYRIDIN-3-YLMETHYL-HYDRAZINE (2-METHOXY-1-METHYL-ETHYL)-HYDRAZINE PYRIDIN-4-YLMETHYL-HYDRAZINE CYCLOBUTYLHYDRAZINE

3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID DI-TERT-BUTYL HYDRAZODICARBOXYLATE tert-butyl azidoformate 1-N-Boc-2-Methylhydrazine tert-butyl 2-cyano-1H-pyrrol-1-ylcarbaMate

1-Boc-2-isopropylhydrazine Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE tert-Butyl 2-methylcarbazate TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

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tert-Butyl carbazate Suppliers

Global( 609)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	+86-86020003 +86-18861157602	sales03@genchem.cn	China	79	58
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	222	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2169	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Hebei Weimiao Import and Export Trade Co., Ltd.	+undefined19948166995	sale01@hbweimiao.com	China	71	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60

Supplier	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Jinan Jianfeng Chemical Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Weimiao Import and Export Trade Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Sigma Audley	58
hebei hongtan Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from tert-Butyl carbazate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Tert-Butyl carbazate 870-46-2	US $98.00-95.00 / kg	1kg	99%	9873	Hebei Weimiao Import and Export Trade Co., Ltd.
2024-04-22	Tert-Butyl carbazate 870-46-2	US $30.00 / kg	1kg	99%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-04-07	tert-Butyl carbazate 870-46-2	US $32.00-1.40 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Tert-Butyl carbazate
870-46-2
US $98.00-95.00 / kg
99%
Hebei Weimiao Import and Export Trade Co., Ltd.

Tert-Butyl carbazate
870-46-2
US $30.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

tert-Butyl carbazate
870-46-2
US $32.00-1.40 / kg
99%
Henan Fengda Chemical Co., Ltd

tert-Butyl carbazate Spectrum

tert-Butyl carbazate(870-46-2)MS tert-Butyl carbazate(870-46-2)¹HNMR tert-Butyl carbazate(870-46-2)¹³CNMR tert-Butyl carbazate(870-46-2)IR1 tert-Butyl carbazate(870-46-2)IR2 tert-Butyl carbazate(870-46-2)Raman

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TERT-BUTOXYCARBONYLHYDRAZINE TERT-BOC-HYDRAZIDE TERT-BUTYLOXYCARBAZATE T-BUTOXYCARBONYL HYDRAZIDE T-BUTYLOXYCARBONYL-HYDRAZIDE tert-Butyl hydrazinocarboxylate tert-Butylcarbazate,98+% BOC-HYDRAZIDE 98% TERT-BUTYL CARBAZATE 99% tert-Butyl carbazate, 97+% tert-Butoxycarbonyl hydrazide, Boc-hydrazide N-T-BUTOXYCARBONYL-HYDRAZIDE CustoM-Made product tert-Butyl carbaza 1-Boc hydrazine tert-Butyl carbazate Hydrazinecarboxylic acid-1,1-dimethyl ester BOC-Hydrazine tert-Butyl carbazate Tert-Cutyl Carbazate tert-Butyl hydrazinoformate Boc-hydrazide≥ 99% (GC) Carbazic acid 1,1-dimethylethyl ester N-Aminocarbamic acid tert-butyl ester tert-Butyl carbazate,99% LABOTEST-BB LT00053500 Boc-hydrazine tert-Butoxycarbonylhydrazine Carbazic Acid tert-Butyl Ester TERT-BUTYL CARBAZATE FOR SYNTHESIS hydrazinecarboxylicacid,1,1-dimethylethylester AKOS B028820 Tert-Butyl carbazateCAS BOC-hydrazide（Tert-Butyl carbazate） tert-Butyl carbazate,tert-Butoxycarbonyl hydrazide, Boc-hydrazide tert-Butyl carbazate tert-Butyl carbazate, 99% 100GR tert-Butyl carbazate, 99% 500GR +-BUTYL CARBAZATE CARBONIC ACID TERT-BUTYL ESTER HYDRAZIDE CARBAZINIC ACID TERT-BUTYL ESTER CARBAZIC ACID TERT-BUTYL ESTER Baloxavir Impurity 35 ert-Butyl carbazate tert-Butyl carbazate T-BOC-HYDRAZIDE tert-Butyl carbazate solution tert-Butyl Carbazate > tert-Butyl carbazate, 99%, for synthesis 1-Boc hydrazine(BOC-NHNH2) tert-Butyl Carbazate (TBC) tert-Butyl Carbazate extrapure, 98% TERT-BUTOXYCARBONYL HYDRAZIDE tert-butyloxycarbonyl-hydrazide T-BOC-HYDRAZIDE T-BUTYLCARBAZATE tert-Butyl N-aminocarbamate tert-butyl hydrazinecarboxylate BOC-HYDRAZIDE BOC-HYDRAZINE BOC-NHNH2 carbazate