Salirasib
- CAS No.
- 162520-00-5
- Chemical Name:
- Salirasib
- Synonyms
- FTS;irasib;CS-1744;Salirasib;Unii-mzh0om550m;Salirasib USP/EP/BP;Farnesylthiosalicylate;FARNESYLTHIOSALICYLIC ACID;S-Farnesylthiosalicylic acid;Salirasib(S-Farnesylthiosalicylic aci)
- CBNumber:
- CB9694198
- Molecular Formula:
- C22H30O2S
- Molecular Weight:
- 358.54
- MDL Number:
- MFCD00467723
- MOL File:
- 162520-00-5.mol
- MSDS File:
- SDS
| Melting point | 64-66°C |
|---|---|
| Boiling point | 486.0±45.0 °C(Predicted) |
| Density | 1.05 |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 3.50±0.36(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | MZH0OM550M |
| NCI Drug Dictionary | salirasib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HS Code | 2930.90.2900 | |||||||||
| NFPA 704 |
|
Salirasib price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1166 | Salirasib ≥98% (HPLC) | 162520-00-5 | 10mg | $51.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1166 | Salirasib ≥98% (HPLC) | 162520-00-5 | 50mg | $347 | 2024-03-01 | Buy |
| TCI Chemical | A3351 | Salirasib | 162520-00-5 | 25MG | $181 | 2024-03-01 | Buy |
| TCI Chemical | A3351 | Salirasib | 162520-00-5 | 100MG | $500 | 2024-03-01 | Buy |
| Cayman Chemical | 10010501 | Farnesyl Thiosalicylic Acid ≥96% | 162520-00-5 | 5mg | $40 | 2024-03-01 | Buy |
Salirasib Chemical Properties,Uses,Production
Description
Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-
Chemical Properties
Pale Yellow Solid
Uses
Salirasib has been used as a farnesyltransferase inhibitor.
Uses
It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
Uses
Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
Definition
ChEBI: Salirasib is a sesquiterpenoid.
Biochem/physiol Actions
Salirasib (Farnesylthiosalicylic acid) is a RAS inhibitor that acts by dislodging the farnesylated protein from the membrane, facilitating Ras degradation. Salirasib impairs downstream signaling and suppresses growth and migration of proliferating tumor cells in in vitro and in vivo models. Salirasib (Farnesylthiosalicylic acid) has recently been shown to possess significant anti-inflammatory and anti-arthritic properties.
References
1) Marciano?et al. (1995),?Farnesyl Derivatives of Rigid Carboxylic Acids – Inhibitors of ras-Dependent Cell Growth; J. Med. Chem.,?38?1267 2) Marom?et al. (1995),?Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid (salirasib) in patients with solid tumors; J. Biol. Chem.,?270?22263 3) Haklai?et al. (1998),?Dislodgement and Accelerated Degradation of Ras; Biochemistry,?37?1306 4) Laheru?et al. (2012),?Integrated preclinical and clinical development of S-trans,trans-Farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer; Invest .New Drugs,?30?2391 5) Tsimberidou?et al. (2010),?Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors; Cancer Chemother. Pharmacol.,?65?235 6) Charette?et al. (2013),?Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms; Cell Death and Disease.?4?e471 7) Maher?et al. (2008),?Activation of TRPA1 by farnesyl thiosalicylic acid; Mol. Pharmacol.,?73?1225
Salirasib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
View Lastest Price from Salirasib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Salirasib
162520-00-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Salirasib
162520-00-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-23 | Salirasib
162520-00-5
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |