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Triethyl phosphite

Triethyl phosphite
Triethyl phosphite structure
CAS No.
122-52-1
Chemical Name:
Triethyl phosphite
Synonyms
P(EtO)3;P(OEt)3;triethyl;(C2H5O)3P;AURORA KA-1231;Phosphorus ether;Triethylphosphit;TriethyPhosphite;TRIETHYLPHOSPHILE;Triethoxyphosphine
CBNumber:
CB9702666
Molecular Formula:
C6H15O3P
Formula Weight:
166.16
MOL File:
122-52-1.mol

Triethyl phosphite Properties

Melting point:
-112°C
Boiling point:
65 °C
Density 
0.969 g/mL at 25 °C(lit.)
vapor pressure 
<6 hPa (20 °C)
refractive index 
n20/D 1.413(lit.)
Flash point:
130 °F
storage temp. 
Flammables area
form 
liquid
color 
colorless
Specific Gravity
0.969
Odor
characteristic, obnoxious, phosphiteodor
explosive limit
3.75-42.5%(V)
Water Solubility 
slightly soluble
Sensitive 
Air & Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
BRN 
956578
CAS DataBase Reference
122-52-1(CAS DataBase Reference)
FDA UNII
6B2R04S55G
NIST Chemistry Reference
Phosphorous acid, triethyl ester(122-52-1)
EPA Substance Registry System
Triethyl phosphite (122-52-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H302-H317-H412-H319-H332-H402
Precautionary statements  P210-P280-P301+P312+P330-P370+P378-P262-P273-P280h-P305+P351+P338
Hazard Codes  Xn
Risk Statements  10-22-36/37/38-20/22
Safety Statements  16-26-36
RIDADR  UN 2323 3/PG 3
WGK Germany  1
RTECS  TH1130000
10-23
Autoignition Temperature 250 °C
TSCA  Yes
HS Code  2920 24 00
HazardClass  3
PackingGroup  III
Toxicity LD50 orl-rat: 1840 mg/kg JACTDZ 1,218,92
NFPA 704
2
0 1

Triethyl phosphite price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T61204 Triethyl phosphite 98% 122-52-1 5ml $17.9 2021-03-22 Buy
Sigma-Aldrich 8.00549 Triethylphosphite for synthesis 122-52-1 100 mL $34.32 2021-03-22 Buy
Sigma-Aldrich 8.00549 Triethylphosphite for synthesis 122-52-1 500 mL $72.52 2021-03-22 Buy
Sigma-Aldrich T61204 Triethyl phosphite 98% 122-52-1 4l $171 2021-03-22 Buy
Alfa Aesar L00339 Triethyl phosphite, 98% 122-52-1 500ml $38.3 2020-06-24 Buy

Triethyl phosphite Chemical Properties,Uses,Production

Chemical Properties

Triethyl phosphite is a clear colorless liquid with a strong foul odor. Insoluble in water; soluble in alcohol and ether. Combustible.Vapors heavier than air.

Uses

Synthesis, plasticizers, stabilizers, lubricant and grease additives.

Uses

Triethyl phosphite is an organophosphorus compound. It is used as a reducing agent; can react with electrophiles to form phosphonates or phosphates; forms a stable complex with copper(I) iodide.
Triethyl phosphite is a very good nucleophile. The carbon adjacent to the bromine is the most electrophilic position, and phosphorus is the only nucleophile. Triethyl phosphite displaces the bromine in an SN2-like process, and back attack by the bromide which is released generates a phosphonate product, in which the α-protons are strongly acidic.

Preparation

Triethyl phosphite is produced in a closed system by reaction of phosphorous trichlorid and ethanol in the presence of an inorganic or organic base. The product is purified by distillation (Bayer AG, 2002a).

Triethyl phosphite is exclusively used as an intermediate for the manufacturing of different products: flame retardants (about 60 %), optical brighteners (about 15 %), pesticides (about 15 %), antioxidants (about 5 %), and pharmaceuticals (about 5 %).

Reactions

This reaction is currently used for the preparation of synthetically useful phosphonate reagents employed in modified retinal studies. Thus, diethyl 3-alkoxycarbonyl-2-propenylphosphonates are prepared in 72-91% yields by the reaction of methyl or ethyl 4-bromocrotonates with triethyl phosphite at 150-160°C. Similarly, diethyl 3-(ethoxycarbonyl)-2 methyl-2-propenylphosphonate is prepared in 81% yield from triethyl phosphite and ethyl 3-methyl-4-chlorocrotonate by heating at 180- 200°C.The diethyl (E)- and (Z)-3-ethoxycarbonyl-3 fluoro-2 -methyl-2-propenylphosphonates are respectively obtained from triethyl phosphite and (E)- or (Z)-4-bromo-2-fuoro-3-methyl-2-butenoates at 140°C.

Reactivity Profile

Triethyl phosphite is colorless, moderately toxic liquid, combustible. Flammable when exposed to heat or flame. When heated to decomposition Triethyl phosphite emits toxic fumes of oxides of phosphorus [Lewis, 3rd ed., 1993, p. 1271].

Health Hazard

Exposure to high concentrations may cause headache, nausea, and dizziness due to reduced chlolinesterase activity.

Fire Hazard

Special Hazards of Combustion Products: May form hazardous decomposition products.

Safety Profile

Moderately toxic by ingestion. A skin and eye irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits toxic fumes of POx.

Toxicity evaluation

The acute toxicity after oral, dermal, and inhalation exposure is relatively low. The oral LD50s in rats ranged between 1840 mg/kg bw (females) and 2470 mg/kg bw (males). Symptoms of rapid breathing and tremors were observed prior to death. In mice LD50 values above 3700 mg/kg bw were recorded. The 6-hour inhalation LC50 with an aerosol of 1.6-3.5 μm MMAD in rats was between 11,100 mg/m3 (females) and 11,600 mg/m3 (males). Clinical signs included eye and upper respiratory irritation, salivation and rapid, shallow breathing. The dermal LD50 in rabbits was between 2800 mg/kg bw (males) and > 3000 mg/kg bw (females).

Triethyl phosphite Preparation Products And Raw materials

Raw materials

Preparation Products


Triethyl phosphite Suppliers

Global( 243)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Richest Group Ltd
18017061086
oled@richest-group.com CHINA 5606 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
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Chongqing Chemdad Co., Ltd
+86-13650506873
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Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Fuxin Pharmaceutical
021-50872116
contact@fuxinpharm.com CHINA 9519 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
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View Lastest Price from Triethyl phosphite manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Triethyl phosphite
122-52-1
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-08-31 Phosphorousacid, triethyl ester
122-52-1
US $0.00 / KG 1KG 99%min 30000 Wuhan Monad Medicine Tech Co.,LTD
2019-07-06 Triethyl phosphite
122-52-1
US $1.00 / kg 1kg 95%-99% 1000kg career henan chemical co

Triethyl phosphite Spectrum


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