1H-Pyrazole-1-carboxamidine hydrochloride
- CAS No.
- 4023-02-3
- Chemical Name:
- 1H-Pyrazole-1-carboxamidine hydrochloride
- Synonyms
- 1H-pyrazole-1-carboximidamide;1-AMIDINOPYRAZOLE HYDROCHLORIDE;Praxadine;1H-pyrazole-1-carboxamidine;PYRAZOLE-1-CARBOXAMIDINE;Zanamivir EP Impurity F;Pyrazole-1-carboxamidine Hydrochloride;1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE;N-GUANYLPYRAZOLE;AMIDINOPYRAZOLE HCL
- CBNumber:
- CB9707005
- Molecular Formula:
- C4H7ClN4
- Molecular Weight:
- 146.58
- MDL Number:
- MFCD00210087
- MOL File:
- 4023-02-3.mol
- MSDS File:
- SDS
Melting point | 167-170 °C(lit.) |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
form | Crystals or Crystalline Powder |
color | White to light yellow |
Water Solubility | Soluble |
BRN | 5448758 |
InChI | InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H |
InChIKey | RBZRMBCLZMEYEH-UHFFFAOYSA-N |
SMILES | N1(C(N)=N)C=CC=N1.[H]Cl |
CAS DataBase Reference | 4023-02-3(CAS DataBase Reference) |
FDA UNII | 12L58GX4AS |
UNSPSC Code | 41116107 |
NACRES | NA.24 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS05,GHS07,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H317-H318-H335-H373-H412 | |||||||||
Precautionary statements | P273-P280-P301+P312-P302+P352-P305+P351+P338-P314 | |||||||||
Hazard Codes | Xi,C | |||||||||
Risk Statements | 36/37/38-36/37-34 | |||||||||
Safety Statements | 26-37/39-45-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
F | 10-21 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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1H-Pyrazole-1-carboxamidine hydrochloride price More Price(48)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 402516 | 1H-Pyrazole-1-carboxamidine hydrochloride 99% | 4023-02-3 | 10g | $52.84 | 2025-07-31 | Buy |
Sigma-Aldrich | Y0001703 | Zanamivir impurity F European Pharmacopoeia (EP) Reference Standard | 4023-02-3 | 10 mg | $118 | 2025-07-31 | Buy |
Sigma-Aldrich | 402516 | 1H-Pyrazole-1-carboxamidine hydrochloride 99% | 4023-02-3 | 50g | $204 | 2025-07-31 | Buy |
TCI Chemical | A2055 | 1-Amidinopyrazole Hydrochloride >98.0%(HPLC)(T) | 4023-02-3 | 5g | $31 | 2025-07-31 | Buy |
TCI Chemical | A2055 | 1-Amidinopyrazole Hydrochloride >98.0%(HPLC)(T) | 4023-02-3 | 25g | $83 | 2025-07-31 | Buy |
1H-Pyrazole-1-carboxamidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystals or crystalline
Uses
1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis
Uses
1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies: ? Preparation of guanidylated hollow fiber membranes. ? Guanylation of amines and in peptide synthesis. ? Synthesis of bis-guanidinium-cholesterol derivatives.
General Description
1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.
Synthesis

288-13-1

420-04-2

4023-02-3
Pyrazole (1.634 g, 24 mmol) and cyanamide (1 g, 24 mmol) were dissolved in 1,4-dioxane (24 mL), followed by the addition of 4 M hydrochloric acid (6 mL) to the 1,4-dioxane solution. The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was placed in an ice-water bath and the product was induced to recrystallize by the addition of ether. The yield of the final product was 43%.
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 8, p. 2497 - 2502
[2] Organic Letters, 2004, vol. 6, # 26, p. 4925 - 4927
[3] Patent: KR101808950, 2017, B1. Location in patent: Paragraph 0233-0236
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 24, p. 2771 - 2774
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 812 - 820
1H-Pyrazole-1-carboxamidine hydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 458 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12826 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
View Lastest Price from 1H-Pyrazole-1-carboxamidine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-07-07 | 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
|
US $100.00 / kg | 1kg | 99% | 5000KG | Hebei Mujin Biotechnology Co.,Ltd | |
|
2025-06-24 | 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
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2025-04-04 | 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
- US $100.00 / kg
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1H-Pyrazole-1-carboxamidine hydrochloride
4023-02-3
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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