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Pamidronate disodium salt

CAS No.
57248-88-1
Chemical Name:
Pamidronate disodium salt
Synonyms
cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
CBNumber:
CB9707409
Molecular Formula:
C3H12NNaO7P2
Molecular Weight:
259.07
MDL Number:
MFCD01938386
MOL File:
57248-88-1.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:53

Pamidronate disodium salt Properties

Melting point 300 °C
storage temp. 2-8°C
solubility H2O: 28 mg/mL
form solid
color white
Merck 14,7003
Stability Hygroscopic
CAS DataBase Reference 57248-88-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII C7S8VWP5DH

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  22-48-41-37/38-20/21/22
Safety Statements  22-26-36/37/39-45
RIDADR  3077
WGK Germany  3
RTECS  SZ6525000
HazardClass  IRRITANT
HS Code  29319090
NFPA 704
0
2 0

Pamidronate disodium salt price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P2371 Pamidronate disodium salt hydrate ≥95% (NMR), solid 57248-88-1 10mg $133 2024-03-01 Buy
Sigma-Aldrich P2371 Pamidronate disodium salt hydrate ≥95% (NMR), solid 57248-88-1 100mg $616 2024-03-01 Buy
Sigma-Aldrich BP615 Disodium pamidronate British Pharmacopoeia (BP) Reference Standard 57248-88-1 100MG $259 2023-06-20 Buy
TCI Chemical D3921 Disodium Pamidronate Hydrate >97.0%(T) 57248-88-1 100mg $52 2024-03-01 Buy
TCI Chemical D3921 Disodium Pamidronate Hydrate >97.0%(T) 57248-88-1 1g $302 2024-03-01 Buy
Product number Packaging Price Buy
P2371 10mg $133 Buy
P2371 100mg $616 Buy
BP615 100MG $259 Buy
D3921 100mg $52 Buy
D3921 1g $302 Buy

Pamidronate disodium salt Chemical Properties,Uses,Production

Description

Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.

Chemical Properties

White Crystals

Originator

Henkel (United Kingdom)

Uses

A farnesyl diphosphate synthase inhibitor

Uses

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.

Uses

A bisphosphonate antiresorptive agent; bone resorption inhibitor.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Aredia (Novartis).

Therapeutic Function

Bone resorption suppressant

Biochem/physiol Actions

Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Veterinary Drugs and Treatments

Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 280)Suppliers
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career henan chemical co
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Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58

View Lastest Price from Pamidronate disodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pamidronate disodium salt USP/EP/BP pictures 2021-07-29 Pamidronate disodium salt USP/EP/BP
57248-88-1
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Pamidronate disodium salt pictures 2021-07-13 Pamidronate disodium salt
57248-88-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Pamidronate disodium salt pictures 2021-07-10 Pamidronate disodium salt
57248-88-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Pamidronate disodium salt Spectrum

3-Amino-1-hydroxy-1-phosphonopropyl phosphonic acid disodium salt Pamidronate Disodium, GCP-23339A, Aminomux, Aredia Pamidronic Acid, Sodium Salt, Hydrate Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt (3-amino-1-hydroxypropylidene)bis-phosphonic acid disodium salt disodium dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate PAMIDRONATE DISODIUM SALT HYDRATE (3-AMINO-1-HYDROXYPROPYLIDINE)BIS-PHOSPHONIC ACID Pamidronate (Pamidronic acid) PaMidronate DisodiuM API 3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid hydrate disodium salt Pamidronate hydrate disodium salt Pamidronate disodium salt hydrate,3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate Pamidronate disodium salt PAMIDRONICDISODIUMSALT (3-Amino-1-hydroxypropylidene)bisphosphonic Acid Disodium 1-Hydroxy-3-aminopropane-1,1-diylbis(phosphonic acid sodium) salt 3-Amino-1-hydroxypropylidenebis[phosphonic acid hydrogen sodium] salt Disodium Pamidronate Hydrate (3-amino-1-hydroxypropylidene)bis-phosphonicacidisodiumsalt (3-amino-1-hydroxypropylidene)diphosphonicaciddisodiumsalt aminohydroxypropylidenediphosphonatedisodiumsalt cgp23339a disodium3-amino-1-hydroxypropylidene-1,1-biphosphonatepentahydrate 3-AMINO-1-HYDROXYPROPYLIDENE-BISPHOSPHONIC ACID, 2NA, PENTAHYDRATE PAMIDRONATE PAMIDRONATE, DISODIUM SALT, PENTAHYDRATE Pamidronic Acid Disodium Salt Disodium 3-Amino-1-hydroxypropane-1,1-diphosphonate CGP 23339AE SodiuM (3-aMino-1-hydroxy-1-phosphonopropyl)phosphonate SodiuM (3-aMino-1-hydroxy-1-phosphonopropyl)phosphonate xhydrate Phosphonicacid, P,P'-(3-aMino-1-hydroxypropylidene)bis-, sodiuM salt (1:2) 3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt 3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate Disodium Pamidronate  Pamidronate disodium hydrate Disodium 3-Amino-1-Hydroxypropane-1,1-Diphosphonate (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid Pamidronate disodium salt hydrate, 98%, farnesyl diphosphate synthase inhibitor Pamidronate (sodium salt) DisodiumPamidronateHydrate> Sodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate hydrate Pamidronate disodium salt USP/EP/BP PAMIDRONATE DISODIUM CAS NO.:57248-88-1 Disodium PamidronateQ: What is Disodium Pamidronate Q: What is the CAS Number of Disodium Pamidronate Q: What is the storage condition of Disodium Pamidronate Q: What are the applications of Disodium Pamidronate Sodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogen phosphonate) 57248-88-1 C3H9NNa2O7P2xH2O C3H9NNa2O7P25H2O C3H9NO7P22Na C3H9NO7P2Na2 C3H11NO7P22Na C3H9NO7P22NaH2O Enzymes, Inhibitors, and Substrates Farnesyl diphosphate synthase BioChemical Biochemicals and Reagents Enzyme Inhibitors by Enzyme