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(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine Structure
(R)-1-BOC-3-(Hydroxymethyl)piperazine structure
CAS No.
278788-66-2
Chemical Name:
(R)-1-BOC-3-(Hydroxymethyl)piperazine
Synonyms
tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-1-Boc-3-(hyroxyMethyl)piperazine
CBNumber:
CB9715509
Molecular Formula:
C10H20N2O3
Molecular Weight:
216.28
MDL Number:
MFCD05863888
MOL File:
278788-66-2.mol
MSDS File:
SDS
Last updated:2023-10-19 10:31:50
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Properties

Melting point 68-70°C
Boiling point 322.9±22.0 °C(Predicted)
Density 1.085±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.97±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey NSILYQWHARROMG-MRVPVSSYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference 278788-66-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Hazard Codes  Xi
Risk Statements  41-52
Safety Statements  26-39
HS Code  2933599590

(R)-1-BOC-3-(Hydroxymethyl)piperazine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00408 (R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2 1g $461 2024-03-01 Buy
Activate Scientific AS3141 (R)-1-Boc-(3-Hydroxymethyl)piperazine 95+% ee 278788-66-2 25g $476 2021-12-16 Buy
AK Scientific X4711 (R)-3-Hydroxymethyl-piperazine-1-carboxylicacidtert-butylester 278788-66-2 10g $517 2021-12-16 Buy
American Custom Chemicals Corporation CCH0037750 (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% 278788-66-2 1G $526 2021-12-16 Buy
Biosynth Carbosynth FB151258 (R)-4-N-Boc-2-hydroxymethyl-piperazine 278788-66-2 2g $619 2021-12-16 Buy
Product number Packaging Price Buy
SYX00408 1g $461 Buy
AS3141 25g $476 Buy
X4711 10g $517 Buy
CCH0037750 1G $526 Buy
FB151258 2g $619 Buy

(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Uses,Production

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine synthesis

1159598-21-6
278788-66-2
Synthesis of (R)-1-BOC-3-(Hydroxymethyl)piperazine from (R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid, tetrahydro-1,3-dioxo-, 1,1-dimethylethyl ester, (8aR)- (R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE

Preparation Products

(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

Global( 231)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boc Chemical Co., Ltd.
021-34975602; +8618721111801 shangli@bocchem.com China 138 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 6992 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Chengdu Feibo Pharm Technology Co., Ltd 		15982321820 abby@arkpharm.com CHINA 3279 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10828 58
Supplier Advantage
Shanghai Boc Chemical Co., Ltd.
58
Capot Chemical Co.,Ltd. 		60
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Chengdu Feibo Pharm Technology Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58

View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER pictures 2019-08-06 (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
278788-66-2
 US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

(R)-1-BOC-3-(Hydroxymethyl)piperazine Spectrum

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)1HNMR(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)FT-IR

278788-66-2((R)-1-BOC-3-(Hydroxymethyl)piperazine)Related Search:

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3-N-Boc-Cis-Tetrahydrofuran-3,4-Diamine tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate (6R,7S)-2-BOC-2-AZA-BICYCLO[2.2.1]HEPT-5-EN-3-ONE (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine
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(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE (R)-1-Boc-3-hydroxymethyl-piperazine H57159 (R)-4-Boc-2-hydroxymethyl-piperazine 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)- (R)-1-Boc-3-(Hydroxymethyl)piperazine ,98% (R)-4-N-Boc-2-hydroxyMeth... (R)-1-Boc-3-(hyroxyMethyl)piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine (3R)-1-Boc-3-(hydroxyMethyl)-piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98% (3R)-3-(hydroxymethyL (3R)-3-(Hydroxymethyl)piperazine ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate PIPERAZINE-1-CARBOXYLIC (3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester 278788-66-2 pharmacetical Piperaizine