4-Amino-3-methylbenzoic acid
- CAS No.
- 2486-70-6
- Chemical Name:
- 4-Amino-3-methylbenzoic acid
- Synonyms
- 3-METHYL-4-AMINOBENZOIC ACID;Fluralaner-034;RARECHEM AL BO 2396;4-Amino-3-methylbenz;4-AMINO-M-TOLUIC ACID;4-Amino-n-toluic acid;3-Methyl-4-AMino acid;Carbidopa Impurity 24;Fluralaner Impurity 54;4-Amino-3-methylbenzoic
- CBNumber:
- CB9724176
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD00007736
- MOL File:
- 2486-70-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-171 °C (lit.) |
|---|---|
| Boiling point | 273.17°C (rough estimate) |
| Density | 1.2023 (rough estimate) |
| refractive index | 1.5810 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.93±0.10(Predicted) |
| color | Pale Brown to Light Brown |
| BRN | 2802615 |
| Stability | Light Sensitive |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H9NO2/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4H,9H2,1H3,(H,10,11) |
| InChIKey | NHFKECPTBZZFBC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(N)C(C)=C1 |
| CAS DataBase Reference | 2486-70-6(CAS DataBase Reference) |
| FDA UNII | 201CXT4H5V |
| NIST Chemistry Reference | 4-Amino-3-methylbenzoic acid(2486-70-6) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-3-methylbenzoic acid price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A63007 | 4-Amino-3-methylbenzoic acid 98% | 2486-70-6 | 1g | $46.6 | 2023-01-07 | Buy |
| Sigma-Aldrich | A63007 | 4-Amino-3-methylbenzoic acid 98% | 2486-70-6 | 10g | $426 | 2023-01-07 | Buy |
| TCI Chemical | A1353 | 4-Amino-3-methylbenzoic Acid >98.0%(HPLC)(T) | 2486-70-6 | 5g | $50 | 2026-04-30 | Buy |
| TCI Chemical | A1353 | 4-Amino-3-methylbenzoic Acid >98.0%(HPLC)(T) | 2486-70-6 | 25g | $150 | 2026-04-30 | Buy |
| Usbiological | 260241 | 4-Amino-3-methylbenzoic acid Asreported | 2486-70-6 | 25g | $393 | 2026-06-03 | Buy |
4-Amino-3-methylbenzoic acid Chemical Properties, Uses, Production
Chemical Properties
beige or light buff to orange
Uses
4-Amino-3-methylbenzoic Acid is used in preparation of Amide-substituted Benzo[d]imidazole compounds as selective inhibitors of indoleamine-2,3-dioxygenases.
Hazard
4-Amino-3-methylbenzoic acid causes skin irritation and serious eye irritation.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
3113-71-1
2486-70-6
At room temperature and under hydrogen atmosphere, 3-methyl-4-nitrobenzoic acid (100 g, 552.04 mmol) was dissolved in methanol (2000 mL) followed by addition of palladium carbon catalyst (5.0 g). The reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give the light yellow solid product 4-amino-3-methylbenzoic acid (80 g, 96% yield).
References
[1] Advanced Synthesis and Catalysis, 2010, vol. 352, # 9, p. 1451 - 1454
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Journal of Organic Chemistry, 2008, vol. 73, # 21, p. 8631 - 8634
[4] Patent: CN106831460, 2017, A. Location in patent: Paragraph 0029-0059
[5] Patent: CN107501106, 2017, A. Location in patent: Paragraph 0025-0047
4-Amino-3-methylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Shenke Pharmaceutical Technology Co. , Ltd. | 0531-61310226 15553113559 | 105935525@qq.com | China | 117 | 58 |
| Hubei Xinkang Pharmaceutical Chemical Co., Ltd | 027-027-59308705 18871579363 | 1248680011@qq.com | China | 9264 | 58 |
| Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd. | 0519-85269522 15906111708 | sunlight68@126.com | China | 99 | 60 |
| Zhejiang Aobang Pharmaceutical & Chemical Co. LTD | 13676682222 13676682222; | 877870302@qq.com | China | 32 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Sunlight Pharmaceutical Co., Ltd | 519-83131668 15995063688 | info@sunlightchem.com | China | 100 | 69 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
View Latest Price from 4-Amino-3-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-14 | 4-Amino-3-methylbenzoic acid
2486-70-6
|
$78.26 | 25Kg/Drum | 98.50%HPLC | 20tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-06-30 | 4-Amino-3-methylbenzoic acid
2486-70-6
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 4-Amino-3-methylbenzoic acid
2486-70-6
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Amino-3-methylbenzoic acid
2486-70-6
- $78.26
- 98.50%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 4-Amino-3-methylbenzoic acid
2486-70-6
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Amino-3-methylbenzoic acid
2486-70-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
