Pheniramine maleate
- CAS No.
- 132-20-7
- Chemical Name:
- Pheniramine maleate
- Synonyms
- Pheneramine Maleate;PHENIRAMINE MALEATE SALT;pm241;Fervex;daneral;ho11513;inhiston;Trimetose;205-051-4;Antolozine
- CBNumber:
- CB9727768
- Molecular Formula:
- C20H24N2O4
- Molecular Weight:
- 356.42
- MDL Number:
- MFCD00079250
- MOL File:
- 132-20-7.mol
| Melting point | 104-108°C |
|---|---|
| Boiling point | 489.25°C (rough estimate) |
| Density | 1.2233 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| color | White |
| Water Solubility | >=1 g/100 mL at 24 ºC |
| λmax | 262nm(lit.) |
| Merck | 14,7235 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| FDA 21 CFR | 310.545; 341.12 |
| CAS DataBase Reference | 132-20-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | NYW905655B |
| EPA Substance Registry System | Pheniramine maleate (132-20-7) |
Pheniramine maleate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2646 | Pheniramine Maleate Pharmaceutical Secondary Standard; Certified Reference Material | 132-20-7 | 300MG | $200 | 2024-03-01 | Buy |
| Sigma-Aldrich | P6902 | Pheniramine maleate salt | 132-20-7 | 5g | $162 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1522301 | Pheniramine maleate United States Pharmacopeia (USP) Reference Standard | 132-20-7 | 150mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | P2271 | Pheniramine Maleate >98.0%(HPLC)(T) | 132-20-7 | 25g | $139 | 2024-03-01 | Buy |
| Sigma-Aldrich | P0850000 | Pheniramine maleate European Pharmacopoeia (EP) Reference Standard | 132-20-7 | p0850000 | $153 | 2024-03-01 | Buy |
Pheniramine maleate Chemical Properties,Uses,Production
Chemical Properties
white powder
Originator
Trimeton Maleate, Schering ,US,1948
Uses
Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
Uses
Used medicinally as an antihistaminic (merck).
Uses
A H1 histamine receptor antagonist.
Uses
Antihistaminic;H1 antagonist
Definition
ChEBI: Pheniramine maleate is an organic molecular entity.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
General Description
White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
General Description
Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.
Air & Water Reactions
Water soluble.
Reactivity Profile
Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Fire Hazard
Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.
Biochem/physiol Actions
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
Pheniramine maleate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Pheniramine maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-08 | Pheniramine maleate
132-20-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-06-15 | Pheniramine maleate
132-20-7
|
US $2150.00 / KG | 1KG | 98% | 1-20mt | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2023-03-10 | Pheniramine maleate
132-20-7
|
US $1.00 / kg | 1kg | 99 | 20tons | Hebei Duling International Trade Co. LTD |
-
- Pheniramine maleate
132-20-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Pheniramine maleate
132-20-7
- US $2150.00 / KG
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- Pheniramine maleate
132-20-7
- US $1.00 / kg
- 99
- Hebei Duling International Trade Co. LTD
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