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Sunitinib

Sunitinib Structure
Sunitinib structure
CAS No.
557795-19-4
Chemical Name:
Sunitinib
Synonyms
SUNITINIB BASE;SUNITINIB MALEATE;SNTI;Suniti;Sutini;SU-11248;sunitinib;Sutent-d4;SU-11248-d4;SUNITINIB-D4
CBNumber:
CB9728174
Molecular Formula:
C22H27FN4O2
Molecular Weight:
398.47
MDL Number:
MFCD09260778
MOL File:
557795-19-4.mol
Last updated:2023-12-20 13:21:23
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Sunitinib Properties

Melting point 189-191°C
Boiling point 572.1±50.0 °C(Predicted)
Density 1.2
Flash point 299.8℃
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 8.5(at 25℃)
form Solid
color Yellow to Dark Orange
CAS DataBase Reference 557795-19-4(CAS DataBase Reference)
NCI Dictionary of Cancer Terms SU11248
FDA UNII V99T50803M
ATC code L01EX01

Pharmacokinetic data

Protein binding 95%
Excreted unchanged in urine 16 (unchanged drug + metabolites)
Volume of distribution 2230 Litres
Biological half-life 40-60 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Safety Statements  24/25
HS Code  29337900

Sunitinib price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 170080 Sunitinib, Free base 557795-19-4 25mg $240 2021-12-16 Buy
Usbiological S8032 Sunitinib Maleate 557795-19-4 100mg $127 2021-12-16 Buy
ChemScene CS-1670 Sunitinib 98.96% 557795-19-4 1g $132 2021-12-16 Buy
Biorbyt Ltd orb154665 Sunitinib base >98% 557795-19-4 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb61102 Sunitinib, Free Base >99% pure 557795-19-4 5G $617.1 2021-12-16 Buy
Product number Packaging Price Buy
170080 25mg $240 Buy
S8032 100mg $127 Buy
CS-1670 1g $132 Buy
orb154665 250mg $615.4 Buy
orb61102 5G $617.1 Buy

Sunitinib Chemical Properties,Uses,Production

Description

Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.

Chemical Properties

Yellow Solid

Originator

Sugen (US)

Uses

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Uses

Labelled Sunitinib (S820000), a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK).

Definition

ChEBI: Sunitinib is a member of pyrroles and a monocarboxylic acid amide. It has a role as an angiogenesis inhibitor, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a vascular endothelial growth factor receptor antagonist, an immunomodulator and a neuroprotective agent. It is functionally related to a 3-methyleneoxindole.

brand name

(Pfizer).

Clinical Use

Tyrosine kinase inhibitor:
Treatment of metastatic renal cell carcinoma (MRCC), gastrointestinal stromal tumours (GIST) and pancreatic neuroendocrine tumours (pNET)

target

VEGFR-1

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine (increased risk of agranulocytosis).
Antivirals: avoid concomitant use with boceprevir.
Avoid concomitant use with other inhibitors or inducers of CYP3A4. Dose alterations may be required.

Metabolism

Metabolised mainly via the cytochrome P450 isoenzyme CYP3A4 to its primary active metabolite, which itself is then further metabolised via CYP3A4.
Elimination is primarily via faeces. In a human mass balance study of [14C]sunitinib, 61% of the dose was eliminated in faeces and 16% by the renal route.

References

[1]hui ep1, lui vw, wong cs, ma bb, lau cp, cheung cs, ho k, cheng sh, ng mh, chan at. preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma. invest new drugs. 2011 dec;29(6):1123-31.

Sunitinib synthesis

100-36-7
356068-93-4
557795-19-4
Synthesis of Sunitinib from N,N-Diethylethylenediamine and 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Sunitinib Preparation Products And Raw materials

Raw materials

5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N,N-Diethylethylenediamine

Preparation Products

Sunitinib Suppliers

Global( 406)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Jinan Million Pharmaceutical Co., Ltd 		+86-531-68659554 +8613031714605 info@millionpharm.com China 153 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Supplier Advantage
AFINE CHEMICALS LIMITED
58
Hebei Yanxi Chemical Co., Ltd. 		58
Sinoway Industrial co., ltd. 		58
shandong perfect biotechnology co.ltd 		58
Jinan Million Pharmaceutical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60

Related articles

View Lastest Price from Sunitinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sunitinib pictures 2024-04-24 Sunitinib
557795-19-4
 US $1.00-0.50 / kg 1kg 99% 200 Jinan Million Pharmaceutical Co., Ltd
Sunitinib pictures 2024-04-22 Sunitinib
557795-19-4
 US $50.00-2.00 / G/Bag 1G/Bag 0.99 100kg Sinoway Industrial co., ltd.
sunitinib pictures 2024-03-12 sunitinib
557795-19-4
 US $0.00 / g 1g 98% HPLC 1kg shandong perfect biotechnology co.ltd
  • Sunitinib pictures
  • Sunitinib
    557795-19-4
  • US $1.00-0.50 / kg
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Sunitinib pictures
  • Sunitinib
    557795-19-4
  • US $50.00-2.00 / G/Bag
  • 0.99
  • Sinoway Industrial co., ltd.
  • sunitinib pictures
  • sunitinib
    557795-19-4
  • US $0.00 / g
  • 98% HPLC
  • shandong perfect biotechnology co.ltd

Sunitinib Spectrum

Sunitinib(557795-19-4)1HNMR

557795-19-4(Sunitinib)Related Search:

Dasatinib monohydrate Methyl 2-hydroxyethyl cellulose Ethylparaben Gefitinib Lapatinib
Ethyl cyanoacetate Ethyl acrylate Teniposide Erlotinib Ethanol
N,N-Dimethyl-1,4-phenylenediamine Tris(hydroxymethyl)aminomethane Ethyl acetate Imatinib ISOXADIFEN-ETHYL
Dihydromyrcenol Imatinib mesylate Sunitinib Malate

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SU-11248 N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Malate N-[2-DiethylaMino(ethyl-d4)]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide SU-11248-d4 Sutent-d4 (Z)-N-(2-(DiethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide Sunitinib (Mixture of E and Z IsoMer) Sunitinib N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide Sunitinib, >=99% sunitinib SUNITINIB-D4 n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- SUNITINIBMALEATE(FORR&DONLY) Sunitinib--- free base Sunitinib，Sutent 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide Suniti N-[2-(diethylaMino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]Methyl}-2,4-diMethyl-1H-pyrrole-3-carboxaMide SUTENT SUNITINIB N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)meth yl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Sunitinib malate(TINIBS) Sunitinib malate for research N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Maleate SUNITINIB (SU 11248) SU-11248;SU11248 Sunitinib (Sutent, SU11248) SNTI (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3-indolinylidene)methyl]-2,4-dimethylpyrrole-3-carboxamide (Z)-Sunitinib Sunitinib USP/EP/BP Sunitinib DISCONTINUED Sunitinib free base (SU-11248) SunitinibQ: What is Sunitinib Q: What is the CAS Number of Sunitinib Q: What is the storage condition of Sunitinib Q: What are the applications of Sunitinib SUNITINIB MALEATE SUNITINIB BASE Sutent, Sunitinib, SU11248 Sutini 557795-19-4 41031-54-7 C22H27FN4O2C4H6O5 C26H33FN4O7 C26H31FN4O6 C22H27N4O2C4H6O5 26H31FN4O6 SU-11248 Inhibitors anti-neoplastic Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sunitinib Molecular Targeted Antineoplastic Heterocyclic Compounds Pharmaceutical intermediate API Tyrosine Kinase Inhibitors