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Chlortetracycline hydrochloride

Chlortetracycline hydrochloride
Chlortetracycline hydrochloride
CAS No.
64-72-2
Chemical Name:
Chlortetracycline hydrochloride
Synonyms
CTC;u-6780;nsc-13252;Auxeomycin;Isphamycin;AUREOMYCIN;Aurofac 100;Aureociclina;Aureocycline;Chlorotetracy
CBNumber:
CB9737862
Molecular Formula:
C22H24Cl2N2O8
Formula Weight:
515.34
MOL File:
64-72-2.mol

Chlortetracycline hydrochloride Properties

Melting point:
210-215 °C (dec.)(lit.)
alpha 
D23 -240°
storage temp. 
2-8°C
solubility 
1 M NaOH: soluble50mg/mL
form 
Powder
color 
faint yellow to yellow
pka
3.3(at 25℃)
Water Solubility 
Soluble in water
Sensitive 
Light Sensitive
Merck 
13,2211
BRN 
3858364
CAS DataBase Reference
64-72-2(CAS DataBase Reference)
EPA Substance Registry System
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy- 6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-(64-72-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  QI7800000
HazardClass  3
Toxicity LD50 orally in rats: 10300 mg/kg (Goldenthal)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Chlortetracycline hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 26430 Chlortetracycline hydrochloride suitable for fluorescence, BioReagent, from 64-72-2 5g $53 2018-11-20 Buy
Sigma-Aldrich 1129007 Chlortetracycline hydrochloride United States Pharmacopeia (USP) Reference Standard 64-72-2 200mg $357.7 2018-11-20 Buy
Alfa Aesar J60095 Chlortetracycline hydrochloride 64-72-2 100g $274 2018-11-13 Buy
Alfa Aesar J60095 Chlortetracycline hydrochloride 64-72-2 25g $98.4 2018-11-13 Buy
Sigma-Aldrich C4881 Chlortetracycline hydrochloride ≥75% (HPLC) 64-72-2 25g $113 2018-11-20 Buy

Chlortetracycline hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis

Uses

Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.

Uses

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Uses

An antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline

brand name

Aureomycin (Lederle).

Purification Methods

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]

Chlortetracycline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Chlortetracycline hydrochloride Suppliers

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