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NAPHTHOL AS-E PHOSPHATE

NAPHTHOL AS-E PHOSPHATE structure

CAS No.: 18228-17-6

Chemical Name:: NAPHTHOL AS-E PHOSPHATE

Synonyms: kg-501;NASEP;KD-501;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);KG-501 (2-naphthol-AS-E-phosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE

CBNumber:: CB9737978

Molecular Formula:: C17H13ClNO5P

Molecular Weight:: 377.72

MDL Number:: MFCD00042718

MOL File:: 18228-17-6.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:14

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NAPHTHOL AS-E PHOSPHATE Properties

Density	1.567±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: soluble
form	A crystalline solid
pka	1.04±0.30(Predicted)
BRN	6664478
FDA UNII	H6R6B93QFC

SAFETY

Risk and Safety Statements

WGK Germany	3
F	8-10-21

NAPHTHOL AS-E PHOSPHATE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	70485	Naphthol AS-E phosphate for histology	18228-17-6	250mg	$105	2024-03-01	Buy
TRC	N368028	Naphthol AS-E phosphate	18228-17-6	100mg	$60	2021-12-16	Buy
ChemScene	CS-0027313	KG-501 98.08%	18228-17-6	10mg	$70	2021-12-16	Buy
Biosynth Carbosynth	EN69791	Naphthol AS-E phosphate - 60%	18228-17-6	500mg	$75	2021-12-16	Buy
Biosynth Carbosynth	EN69791	Naphthol AS-E phosphate - 60%	18228-17-6	250mg	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
70485	250mg	$105	Buy
N368028	100mg	$60	Buy
CS-0027313	10mg	$70	Buy
EN69791	500mg	$75	Buy
EN69791	250mg	$45	Buy

NAPHTHOL AS-E PHOSPHATE Chemical Properties,Uses,Production

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

target

NAPHTHOL AS-E PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

NAPHTHOL AS-E PHOSPHATE Suppliers

Global( 76)Suppliers

Target	Value
CREB ()

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58

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NAPHTHOL AS-E PHOSPHATE N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate KD-501 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)- KG-501 (2-naphthol-AS-E-phosphate) N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501 NASEP 2-naphthol-AS-E-phosphate 2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE KG-501(NaphtholAS-Ephosphate) kg-501 Epigenetic Reader Domain,inhibit,Inhibitor,KG 501,Naphthol AS-E,KG501,KG-501 18228-17-6 18228-27-6 8228-17-6 C17H13ClNO5P BioChemical Biochemicals and Reagents Enzyme Substrates Enzymes, Inhibitors, and Substrates Substrates by Enzyme Substrates API