ChemicalBook
Chinese Japanese Germany Korea

Cyclooctapentylose

Cyclooctapentylose
Cyclooctapentylose structure
CAS No.
17465-86-0
Chemical Name:
Cyclooctapentylose
Synonyms
schardinger;Cavasol? W8;Cavamax? W8;CYCLOOCTAOSE;Cavamax(R) W8;CYCLOFLO(TM) 42;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;cyclooctapentylose;GAMMA-CYCLODEXTRIN
CBNumber:
CB9750405
Molecular Formula:
C48H80O40
Formula Weight:
1297.12
MOL File:
17465-86-0.mol

Cyclooctapentylose Properties

Melting point:
≥300 °C
Boiling point:
845.2°C (rough estimate)
alpha 
[α]D25 +174~+179° (c=1, H2O) (After Drying)
Density 
1.2064 (rough estimate)
refractive index 
1.7500 (estimate)
Flash point:
450℃
solubility 
1 M NaOH: 25 mg/mL, may be clear to slightly hazy
form 
powder
color 
white
optical activity
[α]/D 174.0 to 180.0°
λmax
λ: 420 nm Amax: ≤0.20
Merck 
14,2718
BRN 
5725162
EPA Substance Registry System
.gamma.-Cyclodextrin(17465-86-0)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-22
WGK Germany  2
RTECS  GU2293080
3
HS Code  29400000

Cyclooctapentylose price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 779431 γ-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC) 17465-86-0 1kg $845 2018-11-13 Buy
Sigma-Aldrich 1154591 Gammacyclodextrin United States Pharmacopeia (USP) Reference Standard 17465-86-0 200mg $384.65 2018-11-20 Buy
TCI Chemical C0869 gamma-Cyclodextrin >99.0%(HPLC) 17465-86-0 5g $55 2018-11-22 Buy
TCI Chemical C0869 gamma-Cyclodextrin >99.0%(HPLC) 17465-86-0 25g $142 2018-11-22 Buy
Sigma-Aldrich G0150000 Gammacyclodextrin 17465-86-0 g0150000 $179 2018-11-23 Buy

Cyclooctapentylose Chemical Properties,Uses,Production

Chemical Properties

White powder or crystal

Chemical Properties

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

Production Methods

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

Pharmaceutical Applications

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

Safety

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
γ-Cyclodextrin
LD50 (rat, IP): 4.6 g/kg
LD50 (rat ,IV): 4.0 g/kg
LD50 (rat, oral): 8.0 g/kg

storage

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Cyclooctapentylose Preparation Products And Raw materials

Raw materials

Preparation Products


Cyclooctapentylose Suppliers

Global( 216)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 211 58
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 xtchem2019@gmail.com CHINA 201 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 704 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23959 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8266 58

View Lastest Price from Cyclooctapentylose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-23 gamma-cyclodextrin
17465-86-0
US $310.00-197.00 / KG 1KG 98% 500kg;1T career henan chemical co
2019-04-23 Cyclooctapentylose
17465-86-0
US $10.00 / kg 1kg 99% 5000kg/month Hebei Chisure Biotechnology Co., Ltd.
2018-05-24 Cyclooctapentylose
17465-86-0
US $1.00 / G 1G 99.5% 100000000 Meihua Biological Technology Co.,Ltd

Cyclooctapentylose Spectrum


17465-86-0(Cyclooctapentylose)Related Search:


  • SCHARDINGER GAMMA-DEXTRIN
  • CYCLOFLO(TM) 42
  • CYCLOOCTAOSE
  • CYCLOOCTAAMYLOSE
  • CYCLOMALTOOCTAOSE
  • GAMMA-CYCLODEXTRIN
  • cyclooctapentylose
  • gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis
  • Sugammadex Impurity 17
  • Sugammadex Impurity 1 (Cyclooctapentylose)
  • GAMMA-CYCLODEXTRIN CELL CULTURE TESTED
  • schardinger
  • GAMMA-CYCLODEXTRIN, MIN 90%
  • Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
  • γ-CD:Cyclooctaamylose
  • ^y-Cyclodextrin hydrate
  • Gamma Cyclodextrin (200 mg)
  • Cavamax(R) W8
  • Schardinger gamma-Dextrin Cyclooctaamylose
  • Alpha and gaMMa Cyclodextrin
  • g-Cyclodextrin hydrate
  • Macrocycles for Host-Guest Chemistry
  • Cyclodextrins
  • Sugars
  • Oligosaccharides
  • Signal Transduction Research Tools
  • Synthetic Reagents
  • BioChemical
  • Chelation/Complexation Compounds
  • Cell Signaling and Neuroscience
  • Cell Biology
  • 17465-86-0
  • C48H80O40
  • C6H10O58
  • g-Cyclodextrin standard
  • Methyl g-cyclodextrin
  • gaMMa-Cyclodextrin >=98%
  • Cavasol? W8
  • Cavamax? W8
  • gamma-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC)
  • Biochemistry
  • Cyclodextrins
  • Functional Materials
  • Macrocycles for Host-Guest Chemistry
  • Oligosaccharides
  • Sugars
  • Dextrins、Sugar & Carbohydrates
  • Alcohols
  • Building Blocks
  • C11 to C30+
  • C20 to C60+
  • Chemical Synthesis
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
Copyright 2017 © ChemicalBook. All rights reserved