Chinese Japanese Germany

Trisodium citrate dihydrate

General description Excellent performance Reference quality standards Effect and application Chemical Properties Uses Production methods
Trisodium citrate dihydrate
Trisodium citrate dihydrate
Chemical Name:
Trisodium citrate dihydrate
Molecular Formula:
Formula Weight:
MOL File:

Trisodium citrate dihydrate Properties

Melting point:
>300 °C(lit.)
Flash point:
173.9 °C
storage temp. 
Store at RT.
H2O: 100 mg/mL
7.0-9.0 (25℃, 50mg/mL in H2O)
Water Solubility 
720 g/L (25 ºC)
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Stable. Incompatible with bases, reducing agents, oxidizing agents.
CAS DataBase Reference
6132-04-3(CAS DataBase Reference)
EPA Substance Registry System
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate(6132-04-3)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  37/38-41-36/37/38
Safety Statements  26-36/37/39-24/25-36
WGK Germany  1
RTECS  GE7810000
HS Code  2918 15 00
Toxicity LD50 orally in Rabbit: > 8000 mg/kg
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Trisodium citrate dihydrate price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 71402 Sodium citrate tribasic dihydrate BioUltra, for molecular biology, ≥99.5% (NT) 6132-04-3 1kg $138 2018-11-13 Buy
Sigma-Aldrich 1613859 Sodium citrate United States Pharmacopeia (USP) Reference Standard 6132-04-3 1g $348 2018-11-13 Buy
Alfa Aesar A12274 Trisodium citrate dihydrate, 99% 6132-04-3 2500g $81.7 2018-11-13 Buy
Alfa Aesar A12274 Trisodium citrate dihydrate, 99% 6132-04-3 500g $22.3 2018-11-13 Buy
Sigma-Aldrich C8532 Sodium citrate tribasic dihydrate for molecular biology, ≥99% 6132-04-3 100g $23.2 2018-11-13 Buy

Trisodium citrate dihydrate Chemical Properties,Uses,Production

General description

Sodium citrate, (molecular formula: Na3C6H5O7 • 2H2O) has molecular weight of 294.1, is a colorless crystal or white crystalline powder product; it is odorless, salty taste, and cool.It will lose its crystal water at 150 °C and will be decomposed at even higher temperature. It also has slight deliquescence in wet air and has weathering property upon hot air. It is soluble in water and glycerol, but insoluble in alcohol and some other organic solvents. Sodium citrate has no toxic effect, and has pH adjusting capability as well as having a good stability, and therefore can be used in the food industry. Sodium citrate has the greatest demand when being used as a food additive; As food additives, it is mainly used as flavoring agents, buffers, emulsifiers, bulking agents, stabilizers and preservatives; in addition, combination between sodium citrate and citric acid can be used in a variety of jams, jelly, juice, drinks, cold drinks, dairy products and pastries gelling agents, flavoring agents and nutritional supplements.

Excellent performance

Sodium citrate is currently the most important citrate. It is produced by two steps: first starch food is fermented to generate citric acid; secondly, citric acid is neutralized by alkali to generate the final products. Sodium citrate has the following excellent performance: The above information is edited by the chemicalbook of Dai xiongfeng.

Reference quality standards

British Pharmacopoeia BP98 Edition
Quality Item Technical Index
Content 99.0-101.0%
PH Meet the rule
Heavy Metal (PB) ≤ 0.001%
Arsenic ≤ 0.0001%
Ferric ≤ 0.001%
Oxalate ≤ 0.03%
Sulfate ≤ 0.015%
Readily carbonizable substance Meet the rule
Chloride ≤ 0.005%
Water 11.0-13.0%
Appearance of the solution clear and transparent solution, colorless
Pyrogen consistent with the test

Effect and application

During the process of clinically taking fresh blood, adding some amount of sterile sodium citrate can play a role in prevent blood clotting; this is exactly taking advantage of the features that calcium citrate can form soluble complexes with calcium ion; In the field of medicine, it is used for the in vitro anti-clotting drugs and anticoagulants drugs, phlegm drugs, and diuretics drugs during blood transfusions; it can also used for cyanide-free electroplating industry; also used as developer for photographic industry. It can be used as flavoring agents, buffering materials, emulsifiers, and stabilizer in the food industry. Moreover, it is also widely used in chemical, metallurgical industry, the absorption of sulfur dioxide exhaust with the absorption rate of 99% and regenerate liquid sulfur dioxide citrate for recycle application. Sodium citrate has a good water solubility and a excellent cheating capability with Ca2 +, Mg2 + and other metal ions; it is biodegradable and has a strong dispersing ability and anti-redeposition ability; Daily-applied chemical detergents use it as alternative to trimer sodium phosphate for production of non-phosphorus detergent and phosphate-free liquid detergent. Adding a certain amount sodium citrate to the detergent can significantly increase the cleaning ability of detergent cleaning. The large scale of application of sodium tripolyphosphate as a builder in detergents is an important discovery in synthetic detergent industry. It is non-toxic without environmental pollution; it can also be acted as a buffer for the production of cosmetics.

Chemical Properties

It is colorless crystals or white crystalline powder, and is odorless, cool and salty. It has no melting point with a relative density of 1.857. It is stable in air at room temperature with loss of crystal water when being heated to 150 °C loss of crystal water; further heating will cause its decomposition. It is insoluble in ethanol but highly soluble in water. 5% aqueous solution has a pH value of 7.6 to 8.6. Rats by intraperitoneal injection: LD50: 1549 mg/kg; ADI without any special provisions (FAOWHO, 1994).


Production methods

It is produced by the neutralization of citric acid by sodium hydroxide or sodium bicarbonate. Dissolve sodium bicarbonate in water upon stirring and heating; add citric acid, continue to heat up to 85-90 °C; adjust the pH to 6.8; adjust active carbon for bleaching. Filter when the mixture is still hot; condense the filtrate under reduced pressure; cool and the crystal comes out; filter, wash, dry to obtain the final products of sodium citrate.
C6H8O7 + 3NaHCO3 → C6H5Na3O7 • 2H2O + 3CO2 ↑ + H2O

Chemical Properties

white powder or colourless crystals

Chemical Properties

Sodium citrate dihydrate consists of odorless, colorless, monoclinic crystals, or a white crystalline powder with a cooling, saline taste. It is slightly deliquescent in moist air, and in warm dry air it is efflorescent. Although most pharmacopeias specify that sodium citrate is the dihydrate, the USP 32 states that sodium citrate may be either the dihydrate or anhydrous material.


Sodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.


An anticoagulant also used as a biological buffer


ChEBI: The dihydrate of trisodium citrate.


Anticoagulant for collection of blood. In photography; as sequestering agent to remove trace metals; as emulsifier, acidulant and sequestrant in foods.

Production Methods

Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.

Pharmaceutical Applications

Sodium citrate, as either the dihydrate or anhydrous material, is widely used in pharmaceutical formulations.
It is used in food products, primarily to adjust the pH of solutions. It is also used as a sequestering agent. The anhydrous material is used in effervescent tablet formulations. Sodium citrate is additionally used as a blood anticoagulant either alone or in combination with other citrates such as disodium hydrogen citrate.
Therapeutically, sodium citrate is used to relieve the painful irritation caused by cystitis, and also to treat dehydration and acidosis due to diarrhea.

Biological Activity

Commonly used laboratory reagent


After ingestion, sodium citrate is absorbed and metabolized to bicarbonate. Although it is generally regarded as a nontoxic and nonirritant excipient, excessive consumption may cause gastrointestinal discomfort or diarrhea. Therapeutically, in adults, up to 15 g daily of sodium citrate dihydrate may be administered orally, in divided doses, as an aqueous solution to relieve the painful irritation caused by cystitis.
Citrates and citric acid enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citrate- or citric acid-containing products.


Sodium citrate dihydrate is a stable material. Aqueous solutions may be sterilized by autoclaving. On storage, aqueous solutions may cause the separation of small, solid particles from glass containers.
The bulk material should be stored in an airtight container in a cool, dry place.

Purification Methods

Crystallise the salt from warm water by cooling to 0o. [Beilstein 3 III 1100, 3 IV 1274.]


Aqueous solutions are slightly alkaline and will react with acidic substances. Alkaloidal salts may be precipitated from their aqueous or hydro-alcohol solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Other incompatibilities include bases, reducing agents, and oxidizing agents.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic products; oral solutions, suspensions, syrups and tablets; nasal, otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Trisodium citrate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Trisodium citrate dihydrate Suppliers

Global( 317)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 18805133257
+86-518-85110578 CHINA 100 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1659 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001 CHINA 18004 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4529 58
career henan chemical co
+86-371-86658258 CHINA 19990 58
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443156
021-57711696 China 9779 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 25106 65

View Lastest Price from Trisodium citrate dihydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-19 Trisodium citrate dihydrate
US $1.00 / kg 10000kg 98% 1000MT career henan chemical co
2017-09-01 Sodium Citrate;Trisodium citrate dihydrate
US $20.00 / KG 25KG 99.0%--100.5% 2000 tons Jiangsu Kolod Food Ingredients Co.,Ltd.

6132-04-3(Trisodium citrate dihydrate)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved