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BENZTHIAZIDE

BENZTHIAZIDE structure

CAS No.: 91-33-8

Chemical Name:: BENZTHIAZIDE

Synonyms: Exna;exva;p1393;Urese;P 1393;Fovane;fouane;Exsalt;Diucen;Edemex

CBNumber:: CB9758542

Molecular Formula:: C15H14ClN3O4S3

Molecular Weight:: 431.94

MDL Number:: MFCD00078969

MOL File:: 91-33-8.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:08

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BENZTHIAZIDE Properties

Melting point	231-232° (U.S. patent); mp 238-239° (P'an)
Boiling point	680.6±65.0 °C(Predicted)
Density	1.4176 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.57±0.20(Predicted)
color	White to Off-White
Water Solubility	2.8mg/L(room temperature)
FDA UNII	1TD8J48L61
EPA Substance Registry System	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P280-P342+P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	26-36
WGK Germany	2
RTECS	DK8400000
Toxicity	LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)

BENZTHIAZIDE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B7149	Benzthiazide	91-33-8	1g	$23.76	2024-03-01	Buy
TRC	B209925	Benzthiazide	91-33-8	500mg	$75	2021-12-16	Buy
Usbiological	262276	Benzthiazide	91-33-8	50mg	$419	2021-12-16	Buy
Medical Isotopes, Inc.	63107	Benzthiazide	91-33-8	100mg	$620	2021-12-16	Buy
American Custom Chemicals Corporation	API0008565	BENZTHIAZIDE 95.00%	91-33-8	100MG	$716.1	2021-12-16	Buy

Product number	Packaging	Price	Buy
B7149	1g	$23.76	Buy
B209925	500mg	$75	Buy
262276	50mg	$419	Buy
63107	100mg	$620	Buy
API0008565	100MG	$716.1	Buy

BENZTHIAZIDE Chemical Properties,Uses,Production

Originator

Exna,Robins,US,1960

Uses

Benzthiazide is a diuretic, antihypertensive agent.

Definition

ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.

Manufacturing Process

The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous solution and 7 ml of dimethylformamide are added 10 grams of 2,4- disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours after which it is concentrated at reduced pressure. The residue is triturated with water. The solid material is recrystallized from methanol-ether after treatment with activated carbon to give 7.2 grams of product, MP 229°- 230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4- Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro- 7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of dimethylformamide is stirred at room temperature for 6 hours. After heating for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N HCl. The product, after recrystallization from acetone, melts at 210°-211°C.

brand name

Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).

Therapeutic Function

Diuretic, Antihypertensive

Safety Profile

Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl^-.

BENZTHIAZIDE Preparation Products And Raw materials

Raw materials

Chloroacetaldehyde Benzyl mercaptan

Preparation Products

BENZTHIAZIDE Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3842	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29627	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9448	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
sgtlifesciences pvt ltd	58
Alfa Chemistry	58
Shaanxi Didu New Materials Co. Ltd	58
Aladdin Scientific	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from BENZTHIAZIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	Benzthiazide 91-33-8	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
	2021-07-09	BENZTHIAZIDE USP/EP/BP 91-33-8	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Benzthiazide
91-33-8
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

BENZTHIAZIDE USP/EP/BP
91-33-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

91-33-8(BENZTHIAZIDE)Related Search:

Xylazine Hydrochloride hydrobentizide Xylazine Chlorothiazide 2-(BENZYLTHIO)ETHYLAMINE HYDROCHLORIDE

4-Chloro-N-methylbenzenesulphonamide 4-CHLORO-1,3-BENZENEDITHIOL CLOFENAMIDE 4-Amino-6-chlorobenzene-1,3-disulfonamide 2-METHYLSULFANYL-ACETAMIDINE

2-AMINO-N-METHYLBENZENESULFONAMIDE 2H-1,2,4-Benzothiadiazine 1,1-dioxide 2-Aminobenzenesulfonamide BENZTHIAZIDE

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Exna Exosalt exva fouane Fovane Freeuril HyDrine hy-drine Lemazide P 1393 p1393 Pfizer 1393 pfizer1393 Proaqua regulon Urese Exsalt 3-[(benzylthio)methyl]-6-chloro-1,1-diketo-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide CHEMBANK1114 BENZTHIAZIDE 6-Chloro-3-[[(phenylMethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide ((benzylthio)methyl)-3chloro-6dioxyde-1,1sulfonamide-7benzothiadiazine-1,2, -1,-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-((benzylthio)menthyl)-6-chloro-,1,1 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl 3-((Benzylthio)methyl)-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-((benzylthio)methyl)-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-[(benzylthio)methyl]-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio 3-[(benzylthio)methyl]-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine1,1-diox 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxi 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide 4-benzothiadiazine-7-sulfonamide,3-((benzylthio)methyl)-6-chloro-,1,1-2h-2 4or6-chloro-2-phenylphenol 6-chloro-3-(((phenylmethyl)thio)methyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 6-chloro-3-[[(phenylmethyl)thio]methyl]-2h-1,2,4-benzothiadiazine-7-sulfonamid 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine1,1-dioxide Aquatag Benzothiazide Dihydrex Diucen diucene Edemex BENZTHIAZIDE USP/EP/BP 3-((Benzylthio)methyl)-6-chloro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide Inhibitor,Carbonate dehydratase,Carbonic Anhydrase,Benzthiazide,inhibit Hydrochlorothiazide Impurity 31 (Benzthiazide) 91-33-8 C15H14ClN3O4S3 43194 Heterocyclic Building Blocks S-Containing