4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
![4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Structure](CAS/GIF/331830-20-7.gif)
- CAS No.
- 331830-20-7
- Chemical Name:
- 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
- Synonyms
- 4-DPCA;1,4-DPCA;TVBAVFFTADCWKG-UHFFFAOYSA-N;4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID;1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo-;HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3
- CBNumber:
- CB9765690
- Molecular Formula:
- C13H8N2O3
- Molecular Weight:
- 240.21
- MDL Number:
- MFCD07357380
- MOL File:
- 331830-20-7.mol
| Boiling point | 419.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 15 mg/ml with warming). |
| form | Tan solid. |
| pka | 2.55±0.20(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 71220 | 1,4-DPCA ≥98% | 331830-20-7 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 71220 | 1,4-DPCA ≥98% | 331830-20-7 | 10mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 71220 | 1,4-DPCA ≥98% | 331830-20-7 | 25mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 71220 | 1,4-DPCA ≥98% | 331830-20-7 | 50mg | $333 | 2024-03-01 | Buy |
| TRC | D585820 | 1,4-DPCA | 331830-20-7 | 50mg | $125 | 2021-12-16 | Buy |
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production
biological activity
1,4-DPCA, a potent and selective inhibitor of prolyl-4-hydroxylase, is also an inhibitor of collagen hydroxylation in chemicalbook cells of human foreskin fibroblasts with IC50 of 2.4µM. 1,4-DPCA inhibits the alpha isoform of prolyl-4-hydroxylase and stabilizes HIF-1alpha protein.
Description
1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM).1 Inhibits collagen deposition via inhibition of collagen proline hydroxylation.2,3 Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury.4
Uses
1,4-DPCA nis a potent competitive inhibitor of avian prolyl 4-hydroxylase in embryonic chick tendon cells and human foreskin fibroblasts in vitro. It is a promotor of wound healing and tissue regeneration in mice.
References
1) Franklin?et al. (2001),?Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J.,?353?333 2) Xiong?et al. (2014),?Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer,?14?1 3) Love and Jones?et al. (2013),?Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res.,?101?3599 4) Zhang?et al. (2015),?Drug induced regeneration in adult mice; Sci. Transl. Med.,?7?290ra92
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3421 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10006 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |