2-GUANIDINOBENZIMIDAZOLE
- CAS No.
- 5418-95-1
- Chemical Name:
- 2-GUANIDINOBENZIMIDAZOLE
- Synonyms
- AKOS BC-1905;TIMTEC-BB SBB003790;TOSLAB-BB TOS-BB-1283;OTAVA-BB BB0111070250;2-Guanidinobenzimiazole;2-GUANIDINOBENZIMIDAZOLE;2-benzimidazolylguanidine;2-GUANIDINOBENZIMIDAZOLE 95%;2-Guanidinobenzimidazole,95%;1h-benzimidazol-2-yl-guanidin
- CBNumber:
- CB9773033
- Molecular Formula:
- C8H9N5
- Molecular Weight:
- 175.19
- MDL Number:
- MFCD00005590
- MOL File:
- 5418-95-1.mol
- MSDS File:
- SDS
| Melting point | 242-244 °C (dec.) (lit.) |
|---|---|
| Boiling point | 296.48°C (rough estimate) |
| Density | 1.2954 (rough estimate) |
| refractive index | 1.6900 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming) |
| form | solid |
| pka | 13.67±0.30(Predicted) |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 5418-95-1(CAS DataBase Reference) |
| FDA UNII | FQ07TOI8GZ |
| EPA Substance Registry System | Guanidine, 1H-benzimidazol-2-yl- (5418-95-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
2-GUANIDINOBENZIMIDAZOLE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G11802 | 2-Guanidinobenzimidazole 95% | 5418-95-1 | 5g | $66.5 | 2024-03-01 | Buy |
| TRC | B197035 | N-1H-Benzimidazol-2-ylguanidine | 5418-95-1 | 2.5g | $120 | 2021-12-16 | Buy |
| Usbiological | 457868 | N-1H-Benzimidazol-2-ylguanidine | 5418-95-1 | 500mg | $319 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H41-1-05 | 2-Guanidinobenzimiazole | 5418-95-1 | 5G | $248 | 2021-12-16 | Buy |
| Matrix Scientific | 065372 | N-1H-Benzimidazol-2-ylguanidine | 5418-95-1 | 500mg | $315 | 2021-12-16 | Buy |
2-GUANIDINOBENZIMIDAZOLE Chemical Properties,Uses,Production
Description
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
Chemical Properties
BROWN-PURPLE FINE CRYSTALLINE POWDER
Uses
N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.
Definition
ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.
References
1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673
2-GUANIDINOBENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-GUANIDINOBENZIMIDAZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18456 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| RYSS TECH LTD | 400-188-0725 +86 21 34310725 13611771617 | China | 2002 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14443 | 57 |
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