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Propylthiouracil

Propylthiouracil
Propylthiouracil structure
CAS No.
51-52-5
Chemical Name:
Propylthiouracil
Synonyms
T 72;6-PTU;PROPYCIL;PROPACIL;PROCASIL;NSC 6498;PROTHYRAN;NSC 70461;Prothycil;Protiural
CBNumber:
CB9777662
Molecular Formula:
C7H10N2OS
Formula Weight:
170.23
MOL File:
51-52-5.mol

Propylthiouracil Properties

Melting point:
218-220 °C(lit.)
Density 
1.1880 (rough estimate)
refractive index 
1.5960 (estimate)
Flash point:
300 °C
storage temp. 
Refrigerator
solubility 
1.1g/l
pka
pKa 7.8; 8.3 (Uncertain)
form 
neat
PH
6-7.5 (5g/l, H2O, 20℃)(slurry)
Water Solubility 
1.1 g/L
Merck 
14,7869
BRN 
130039
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
CAS DataBase Reference
51-52-5(CAS DataBase Reference)
NIST Chemistry Reference
Tegretol(51-52-5)
EPA Substance Registry System
4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo- (51-52-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-40
Safety Statements  36/37-45
WGK Germany  3
RTECS  YR1400000
Hazard Note  Harmful/Irritant
HS Code  29335995
Hazardous Substances Data 51-52-5(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 1250 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.

Propylthiouracil price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46698 6-Propyl-2-thiouracil VETRANAL , analytical standard 51-52-5 250mg $52 2018-11-13 Buy
Sigma-Aldrich 1578000 Propylthiouracil United States Pharmacopeia (USP) Reference Standard 51-52-5 200mg $348 2018-11-13 Buy
TCI Chemical P0533 6-Propyl-2-thiouracil >99.0%(T) 51-52-5 25g $60 2018-11-22 Buy
Cayman Chemical 14069 Propylthiouracil ≥98% 51-52-5 10g $25 2018-11-13 Buy
Cayman Chemical 14069 Propylthiouracil ≥98% 51-52-5 25g $48 2018-11-13 Buy

Propylthiouracil Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Chemical Properties

White crystalline solid or powder. Odorless. Bitter taste.

Uses

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen

Uses

antibacterial

Definition

ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

General Description

Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.

General Description

Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation).

Air & Water Reactions

Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.

Hazard

Possible carcinogen.

Fire Hazard

Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.

Clinical Use

Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS.

Potential Exposure

Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications.

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira- tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with run- ning water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical obser- vation is recommended for 24?48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]

Incompatibilities

This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air.

Waste Disposal

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Propylthiouracil Preparation Products And Raw materials

Raw materials

Preparation Products


Propylthiouracil Suppliers

Global( 241)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20229 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Taizhou Creating Chemical Co., Ltd 86-576 88827176 18906581668
86- 576 88822496 post@creatingchem.com China 130 64
Hubei Yuancheng Saichuang Technology Co., Ltd. 18062666868/13048470578 QQ2355779403/2355880551
023-60363599,027-68886696 andy@ycgmp.com,2355880551@qq.com,2355779403@qq.com China 5081 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Propylthiouracil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Propylthiouracil
51-52-5
US $8.00 / kg 1kg 99% 100KG career henan chemical co

Propylthiouracil Spectrum


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