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Propylthiouracil

Propylthiouracil
Propylthiouracil structure
CAS No.
51-52-5
Chemical Name:
Propylthiouracil
Synonyms
T 72;6-PTU;PROPYCIL;PROPACIL;PROCASIL;NSC 6498;PROTHYRAN;NSC 70461;Prothycil;Protiural
CBNumber:
CB9777662
Molecular Formula:
C7H10N2OS
Formula Weight:
170.23
MOL File:
51-52-5.mol

Propylthiouracil Properties

Melting point:
218-220 °C(lit.)
Density 
1.1880 (rough estimate)
refractive index 
1.5960 (estimate)
Flash point:
300 °C
storage temp. 
Refrigerator
solubility 
1.1g/l
pka
pKa 7.8; 8.3 (Uncertain)
form 
neat
PH
6-7.5 (5g/l, H2O, 20℃)(slurry)
Water Solubility 
1.1 g/L
Merck 
14,7869
BRN 
130039
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
CAS DataBase Reference
51-52-5(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
721M9407IY
NIST Chemistry Reference
Tegretol(51-52-5)
Proposition 65 List
Propylthiouracil
EPA Substance Registry System
Propylthiouracil (51-52-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H351
Precautionary statements  P280-P301+P312+P330-P281
Hazard Codes  Xn,Xi
Risk Statements  22-40
Safety Statements  36/37-45
WGK Germany  3
RTECS  YR1400000
Hazard Note  Harmful/Irritant
HS Code  29335995
Toxicity LD50 orally in Rabbit: 1250 mg/kg

Propylthiouracil price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46698 6-Propyl-2-thiouracil VETRANAL , analytical standard 51-52-5 250mg $53.1 2019-12-02 Buy
Sigma-Aldrich 1578000 Propylthiouracil United States Pharmacopeia (USP) Reference Standard 51-52-5 200mg $352.8 2019-12-02 Buy
TCI Chemical P0533 6-Propyl-2-thiouracil >99.0%(T) 51-52-5 25g $65 2020-06-24 Buy
Cayman Chemical 14069 Propylthiouracil ≥98% 51-52-5 10g $25 2020-06-24 Buy
Cayman Chemical 14069 Propylthiouracil ≥98% 51-52-5 25g $48 2020-06-24 Buy

Propylthiouracil Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Chemical Properties

White crystalline solid or powder. Odorless. Bitter taste.

Uses

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen

Uses

antibacterial

Definition

ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

General Description

Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.

General Description

Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation).

Air & Water Reactions

Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.

Hazard

Possible carcinogen.

Fire Hazard

Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.

Clinical Use

Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS.

Potential Exposure

Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications.

Carcinogenicity

Propylthiouracil is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]

Incompatibilities

This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air.

Waste Disposal

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Propylthiouracil Preparation Products And Raw materials

Raw materials

Preparation Products


Propylthiouracil Suppliers

Global( 305)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28234 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58

View Lastest Price from Propylthiouracil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Propylthiouracil
51-52-5
US $8.00 / kg 1kg 99% 100KG career henan chemical co

Propylthiouracil Spectrum


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