BEPOTASTINE BESILATE | 190786-44-8

BEPOTASTINE BESILATE Properties

Melting point	161-163°
alpha	D20 +6.0° (c = 5 in methanol)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form	Solid
color	White to Light Beige
Stability	Hygroscopic
FDA UNII	6W18MO1QR3

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

BEPOTASTINE BESILATE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23721	Bepotastine (besylate) ≥95%	190786-44-8	5mg	$44	2024-03-01	Buy
Cayman Chemical	23721	Bepotastine (besylate) ≥95%	190786-44-8	10mg	$78	2024-03-01	Buy
Cayman Chemical	23721	Bepotastine (besylate) ≥95%	190786-44-8	25mg	$172	2024-03-01	Buy
Usbiological	003877	Bepotastine Besylate	190786-44-8	5mg	$425	2021-12-16	Buy
TRC	B317000	(S)-BepotastineBesylate	190786-44-8	50mg	$280	2021-12-16	Buy

Product number	Packaging	Price	Buy
23721	5mg	$44	Buy
23721	10mg	$78	Buy
23721	25mg	$172	Buy
003877	5mg	$425	Buy
B317000	50mg	$280	Buy

BEPOTASTINE BESILATE Chemical Properties,Uses,Production

Description

Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh marketed non-sedating histamine H₁ antagonist. Its very low sedative side effect is due to very poor penetration in the central nervous system. Besides its potent and long-acting activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD₄ in tracheal smooth muscle and ileum, IL-5 production by human peripheral blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral blood. As a consequence, it is currently being developed against other allergic and respiratory disorders.

Description

Bepotastine is an antagonist of the histamine H₁ receptor that is selective over H₃, α₁-, α₂-, and β-adrenergic, dopamine D_2long, serotonin 5-HT₂, muscarinic acetylcholine, and benzodiazepine receptors. It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED₅₀ = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED₅₀ = 3.2 μg/kg). Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner. Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.

Chemical Properties

Off-White to Light Beige Solid

Originator

UBE (Japan)

Uses

Bepotastine is a histamine H1 receptor anatagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).

Uses

Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7

Definition

ChEBI: An organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic co junctivitis.

Manufacturing Process

Manufacturing process for BEPOTASTINE BESILATE includes these steps as follows: Step A: Synthesis of Methyl 2-endo-hydroxy-1-exo-hydroxymethyl-3a,8b-cis-2,3,3a,8b-tetrahydro- 1H-5-cyclopenta[b]benzofurancarboxylate,Step B: Synthesis of Methyl 3-methyl-trans-4a-cisoid-4a,5a-cis-5a-1,4a,5,5a,10b,10c-hexahydro-7- dioxin o[5,4-a]cyclopenta[b]benzofurancarboxylate,Step C: Synthesis of 3-Methyl-trans-4a-cosoid-4a,5a-cis-5a-1,4a,5,5a,10b,10c-hexahydro-7- dioxino[5,4-a]cyclopenta[b]benzofuranylmethanol,Step D: Synthesis of 7-Chloromethyl-3-methyl-trans-4a-cisoid-4a,5a-cis-5a-1,4a,5,5a,10b,10chexahydrodioxino[5,4-a]cyclopenta[b]benzofuran,Step E: Synthesis of 4-[3-Methyl-trans-4a-cisoid-4a,5a-cis-5a-1,4a,5,5a,10b,10c-hexahydro-7- dioxino[5,4-a]cyclopenta[b]benzofuranyl]butyric acid, Step F: Synthesis of Methyl 4-[2-endo-hydroxy-1-exo-hydroxymethyl-3a,8b-cis-2,3,3a,8btetrahydro-1H-5- cyclopenta[b]benzofuranyl]butyrate, Step G: Synthesis of Methyl 4-[2-endo-acetoxy-1-exo-hydroxymethyl-3a,8b-cis-2,3,3a,8btetrahydro-1H-5-cyclopenta[b]benzofuranyl]butyrate, Step H: Synthesis of Methyl ester of 11,15-dideoxy-11-acetoxy-16-methyl-15-oxo-18,19- tetradehydro-5,6,7-trinor-4,8-inter-m-phenylene PGI2,Step I: Synthesis of 11-Deoxy-11-acetoxy-16-methyl-18,19-tetradehydro-5,6,7-trinor-4,8-inter-mphenylene PGI2.To a solution of 54 mg of methyl ester of 11-deoxy-11-acetoxy-16-methyl- 18,19-tetradehydro-5,6,7-trinor-4,8-inter-m-phenylene PGI2 in 4.5 ml of anhydrous methanol was added 0.001 ml of 4.8 N sodium methoxide under argon, and the reaction mixture was stirred for 1.5 hours at room temperature. After addition of acetic acid to the reaction mixture and concentration of the mixture, the residue was dissolved in 20 ml of ethyl acetate, and the solution was washed with aqueous saturated solution of sodium hydrogen carbonate, water and aqueous saturated solution of sodium chloride, dried and concentrated to afford 55 mg of an oily material. This oily material was purified by column chromatography using ethyl acetate and cyclohexane (3:1) as eluent to give 48 mg of the methyl ester of 16- methyl-18,19-tetradehydro-5,6,7-trinor-4,8-inter-m-phenylene PGI2.

brand name

Talion

Therapeutic Function

Antiallergic

BEPOTASTINE BESILATE Preparation Products And Raw materials

Raw materials

Phosphonic acid,(3-methyl-2-oxo-5-heptynyl)-, dimethyl ester Thionyl chloride BENZOFURANCARBOXYLIC ACID Sodium bicarbonate Lithium Aluminum Hydride

Sodium Methoxide CERIUM(III) CHLORIDE HEPTAHYDRATE p-Toluenesulfonic acid monohydrate

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Preparation Products

BEPOTASTINE BESILATE Suppliers

Global( 278)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58

View Lastest Price from BEPOTASTINE BESILATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-07-26	BEPOTASTINE BESILATE 190786-44-8	US $30.00 / kg	1kg	99%	1000tons	Henan Bao Enluo International TradeCo.，LTD
2023-04-20	Bepotastine Besilate 190786-44-8	US $50.00 / kg	1kg	99%	100 tons	Hebei Duling International Trade Co. LTD
2023-03-06	Bepotastine Besilate 190786-44-8	US $10.70 / Kg/Bag	10g	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

BEPOTASTINE BESILATE
190786-44-8
US $30.00 / kg
99%
Henan Bao Enluo International TradeCo.，LTD

Bepotastine Besilate
190786-44-8
US $50.00 / kg
99%
Hebei Duling International Trade Co. LTD

Bepotastine Besilate
190786-44-8
US $10.70 / Kg/Bag
99%
Hebei Guanlang Biotechnology Co,.LTD

BEPOTASTINE BESILATE Spectrum

BEPOTASTINE BESILATE(190786-44-8)¹HNMR

190786-44-8(BEPOTASTINE BESILATE)Related Search:

sodium phenyl sulfate Isopropyl Benzenesulfonate Butyl Benzenesulfonate 2-hydroxyethyl benzenesulfonate Methyl benzenesulfonate

Ramelteon 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid Bepotastine Ethyl Ester 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-

Fasudil hydrochloride FMOC-GLY-GLY-GLY-OH 5-alpha-Hydroxy- Laxogenin 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Benzenesulfonamide Ethyl benzenesulphonate

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4-[4-[(4-chlorophenyl)-pyridin-2-ylMethoxy]piperidin-1-yl]butanoic acid benzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1) Benzenesulfonate salt BEPOTASTINE BESILATE (+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate 4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate Talion (TN) Bepotastine Beslilat Bepotastine Besylate 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid (+)-(S)-4-[4-[1-(4-Chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid benzenesulfonate bepotastine benzenesulfonate salt (S)-4-[4-(4-Chlorophenyl-2-pyridylMethoxy)piperidinyl]butyric Acid Benzenesulfonate 4-[(S)-(4-Chlorophenyl)-2-pyridinylMethoxy]-1-piperidinebutanoic Acid Benzenesulfonate BB Bepotastine Benzenesulfonate Bepreve Talion TAU 284 Bepotastine Beslilate (S)-Bepotastine Besylate Bepotastine Besilate (This product is only available in Japan.) (S)-4-[4-[(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl]butanoic Acid Benzenesulfonate 4-[4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl]butanoic Acid Benzenesulfonate BEPOTASTINE BESILATE USP/EP/BP Betastine besylate Bepotastine Besilate (Bepreve) Bepotastine BesilateQ: What is Bepotastine Besilate Q: What is the CAS Number of Bepotastine Besilate Q: What is the storage condition of Bepotastine Besilate Q: What are the applications of Bepotastine Besilate Benzestatine CS-645 CS-487 (S)-4-(4-((4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid compound with benzenesulfonic acid (1:1) (S)-4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid, benzenesulfonic acid 190786-44-8 C21H25ClN2O3C6H6O3S C27H31ClN2O6S 54706 Inhibitors Other APIs Aromatics Drug Analogues Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API Amino Acids & Derivatives Coronavirus