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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2381268-71-7
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
OP-5244;OP5244,OP 5244
CBNumber:
CB98197639
Molecular Formula:
C19H29ClN5O9P
Molecular Weight:
537.89
MDL Number:
MFCD34368525
MOL File:
2381268-71-7.mol
Last updated:2025-04-18 09:53:09
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INDEX NAME NOT YET ASSIGNED Properties

Density 1.84±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
solubility DMSO : 250 mg/mL (464.78 mM; Need ultrasonic)
form Solid
pka 2.57±0.10(Predicted)
color White to pink

INDEX NAME NOT YET ASSIGNED price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0135638 OP-5244 2381268-71-7 5mg $850 2021-12-16 Buy
ChemScene CS-0135638 OP-5244 2381268-71-7 10mg $1400 2021-12-16 Buy
ChemScene CS-0135638 OP-5244 2381268-71-7 25mg $2950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0135638 5mg $850 Buy
CS-0135638 10mg $1400 Buy
CS-0135638 25mg $2950 Buy

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Uses

OP-5244 is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research[1].

in vivo

OP-5244 (15 mg/kg/day; s.c. for 13 d) exhibits anti-tumor effects as a single agent as shown by the tumor growth inhibition in mice[1].
OP-5244 (150 mg/kg; p.o. twice daily for 16 d) increases CD8+ T cells infiltration and reverses immunosuppression in mice[1].
OP-5244 (0.2 mg/kg; i.v.) exhibits terminal elimination half-lives (rat 8.5, dog 0.82, cyno 4.6 h) due to moderate plasma clearance (rat 0.18, dog 1.22, cyno 0.05 L/kg/h) and low steady-state volume of distribution (rat 0.22, dog 0.29, cyno 0.10 L/kg/h)[1].
OP-5244 (10 mg/kg; p.o.) exhibits Cmax (rat 0.82, dog 1.25, cyno 1.72 μM) and AUC (rat 1.96, dog 1.75, cyno 14.2 μM h) [1].

Animal Model:BALB/c mice with breast cancer[1]
Dosage:15 mg/kg/day
Administration:S.c. for 13 days
Result:Inhibited tumor growth.
Showed a 95% lower ADO/AMP ratio compared to that of the vehicle group.

References

[1] Du X, et, al. Orally Bioavailable Small Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression Through Blockade of Adenosine Production. J Med Chem. 2020 Aug 31. DOI:10.1021/acs.jmedchem.0c01086

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32239 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 13980902949; market@dingdangchem.com China 1852 55
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Chengdu DingDang Pharmaceutical Co., Ltd. 55
DC Chemicals 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
OP-5244 OP5244,OP 5244 2381268-71-7 C19H29ClN5O9P