YQ128
- CAS No.
- 2454246-18-3
- Chemical Name:
- YQ128
- Synonyms
- YQ128;YQ128,inhibit,YQ 128,Inhibitor,NOD-like Receptor (NLR),Interleukin Related,YQ-128;3-Thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-;N-[(5-chloro-2-propoxyphenyl)methyl]-N-(2-{4-[(pr op-2-yn-1-yl)sulfamoyl]phenyl}ethyl)-2-(thiophen- 3-yl)acetamide
- CBNumber:
- CB98199880
- Molecular Formula:
- C27H29ClN2O4S2
- Molecular Weight:
- 545.11
- MDL Number:
- MFCD32263442
- MOL File:
- 2454246-18-3.mol
YQ128 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0106043 | YQ128 99.65% | 2454246-18-3 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0106043 | YQ128 99.65% | 2454246-18-3 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0106043 | YQ128 99.65% | 2454246-18-3 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0106043 | YQ128 99.65% | 2454246-18-3 | 100mg | $2250 | 2021-12-16 | Buy |
YQ128 Chemical Properties,Uses,Production
Biological Activity
YQ128 is a potent and selective second-generation NLRP3 inflammasome inhibitor with IC50 of 0.30 μM. YQ128 significantly and selectively inhibited the production of IL-1β, but not TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity.
in vitro
YQ128 (0.3-100 μM; 30 mins) dose dependently suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC 50 of 1.59 μM.
YQ128 (20 μM; 2 hours) shows no significant toxic effects on hCMEC/D3 cells.
Cell Viability Assay
| Mouse peritoneal macrophages | |
| Concentration: | 0.3, 1.0, 3.0, 10, 30, 100 μM |
| Incubation Time: | 30 mins |
| Result: | Suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC 50 of 1.59 μM. |
in vivo
YQ128 (iv; 20 mg/kg) has an intermediate terminal plasma half-life (t 1/2 ) of 6.6 hours after iv administration.
YQ128 (oral ; 20 mg/kg) shows delayed gastrointestinal absorption with at max and c max of 12 h and 73 ng/mL, respectively. Oral bioavailability (F oral < /sub> ) is estimated as 10%.
YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vd ss ) of 8.5 L/kg and rapid total clearance (CL tot ) of 41 mL/min/kg.
has been shown to trigger IL-1β production in a NLRP3-dependent manner in C57BL/6 mice. < /p> < tr>
Animal Model: Sprague-Dawley rats (200-250 g) Dosage: 20 mg/kg (Pharmacokinetic Analysis) Iv Result: < td class="col2"> Had an intermediate terminal plasma half-life (t 1/2 ) of 6.6 hours after iv administration.
YQ128 Preparation Products And Raw materials
Raw materials
Preparation Products
YQ128 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 2887 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2989 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9747 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9038 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 15502154572 | yuben012@sina.com | China | 504 | 58 |