ChemicalBook >> CAS DataBase List >>4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT structure

CAS No.: 153436-22-7

Chemical Name:: 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

Synonyms: GAVESTINEL;1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-;4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT;4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt

CBNumber:: CB9845365

Molecular Formula:: C18H12Cl2N2O3

Molecular Weight:: 375.21

MDL Number:: MFCD00923984

MOL File:: 153436-22-7.mol

Last updated:2023-05-04 17:34:34

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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Properties

Melting point	>270°C (dec.)
Boiling point	701.1±60.0 °C(Predicted)
Density	1.561±0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.77±0.30(Predicted)
form	Solid
color	Pale Yellow
Stability	Hygroscopic
FDA UNII	318X4QY113

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	2348	Gavestinel ≥98%(HPLC)	153436-22-7	10	$183	2021-12-16	Buy
Tocris	2348	Gavestinel ≥98%(HPLC)	153436-22-7	50	$771	2021-12-16	Buy

Product number	Packaging	Price	Buy
2348	10	$183	Buy
2348	50	$771	Buy

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Chemical Properties,Uses,Production

Uses

Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).

Definition

ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.

Biological Activity

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	461	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
EMMX Biotechnology LLC	60
Suzhou Chenrui Biotechnology Co. LTD	58

153436-22-7(4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT)Related Search:

4-CHLORO-1H-INDOLE-2-CARBALDEHYDE 6-CHLORO-2-METHYLINDOLE 6-CHLORO-1H-INDOLE-2-CARBALDEHYDE 4-chloro-1H-indole-2-carboxylic acid 6-Chloroindole-2-carboxylic acid

4,6-DICHLORO-2-METHYLINDOLE 4-CHLORO-2-METHYL-1H-INDOLE (6-CHLORO-1H-INDOL-2-YL)-METHANOL 4,6-Dichloro-1H-indole-2-carboxylic acid 4,6-Dichloro-1H-indole

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

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GAVESTINEL 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]- 153436-22-7 C18H12Cl2N2O3 C18H11Cl2N2O3Na