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Mildronate

CAS No.
76144-81-5
Chemical Name:
Mildronate
Synonyms
3-(2,2,2-triMethylhydraziniuM)propionate dehydrate;2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt;MET88;Quateri;Kvaterin;Quaterin;Mildrote;Meldomiun;Mildonate;MILDRONATE
CBNumber:
CB9850590
Molecular Formula:
C6H14N2O2
Molecular Weight:
146.19
MDL Number:
MFCD00876389
MOL File:
76144-81-5.mol
Last updated:2024-03-21 10:15:46

Mildronate Properties

Melting point 85-900C
storage temp. Refrigerator
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
CAS DataBase Reference 76144-81-5(CAS DataBase Reference)
FDA UNII 73H7UDN6EC

SAFETY

Risk and Safety Statements

Mildronate price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M344450 Mildronate 76144-81-5 100mg $140 2021-12-16 Buy
Matrix Scientific 139821 Mildronate 95%+ 76144-81-5 1g $436 2021-12-16 Buy
American Custom Chemicals Corporation API0000658 MILDRONATE 95.00% 76144-81-5 100MG $525 2021-12-16 Buy
Medical Isotopes, Inc. 12345 Mildronate 76144-81-5 250mg $590 2021-12-16 Buy
American Custom Chemicals Corporation API0000658 MILDRONATE 95.00% 76144-81-5 250MG $685 2021-12-16 Buy
Product number Packaging Price Buy
M344450 100mg $140 Buy
139821 1g $436 Buy
API0000658 100MG $525 Buy
12345 250mg $590 Buy
API0000658 250MG $685 Buy

Mildronate Chemical Properties,Uses,Production

Description

Mildronate is a cardiac and neuroprotective drug. It is a compound with a new structure first developed by Latvia Institute of Organic Synthesis. It was first developed by Grindeks in the former Soviet Union in 1989. On the market, the drug is a structural analog of carnitine, which can compete with carnitine for γ-trimethylaminobutyrate hydroxylase, reduce the concentration of free carnitine and long-chain acetylcarnitine in cells, so it can inhibit Carnitine-dependent fatty acid oxidation. Meldonium was added to the WADA list of banned substances on January 1, 2016 because of "evidence of its use by athletes with the intention of enhancing performance."

Chemical Properties

White Crystalline Powder

Uses

Mildronate is a drug used to treat angina, myocardial infarction, and chronic heart failure. It is a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium.This compound generally contains a significant amount of water.

Definition

ChEBI: Mildronate is an ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes. It has a role as a cardioprotective agent, a neuroprotective agent and an EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor.

General Description

Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acida-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate is efficient in the treatment of heart is chemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the treatment of brain circulation disorders. It appears to improve patients’ mood; they become more active, their motor dysfunction decreases, and asthenia, dizziness and nausea become less pronounced. Since the brain does not utilize fatty acids as fuel other mechanisms of action of mildronate in CNS should be considered. Several reports indicate the possible existence of an alternative, non-carnitine dependent mechanism of action of mildronate. Our recent findings suggest that CNS effects of mildronate could be mediated by stimulation of the nitric oxide production in the vascular endothelium by modification of the ? butyrobetaine and its esters pools. It is hypothesized that mildronate may increase the formation of the ?-butyrobetaine esters. The latter are potent cholinomimetics and may activate eNOS via acetylcholine receptors or specific?-butyrobetaine ester receptors.

Pharmacology

Mildronate is efficient in the treatment of heart is chemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the treatment of brain circulation disorders. It appears to improve patients’ mood; they become more active, their motor dysfunction decreases, and asthenia, dizziness and nausea become less pronounced. Since the brain does not utilize fatty acids as fuel other mechanisms of action of mildronate in CNS should be considered. Several reports indicate the possible existence of an alternative, non-carnitine dependent mechanism of action of mildronate. Our recent findings suggest that CNS effects of mildronate could be mediated by stimulation of the nitric oxide production in the vascular endothelium by modification of the ? butyrobetaine and its esters pools.

Side effects

Possible side effects of Mildronate treatment were an allergic reaction , weakness , headache , and discomfort in the epigastrium. According to the manufacturer of Mildronate GX, the commercial pharmaceutical product of meldonium, there are some rare adverse effects, including allergic reactions (redness and itchy skin, urticaria, rash, and/or angioedema), dyspepsia, tachycardia, and change (increase or decrease) in blood pressure.

Clinical claims and research

Mildronate (Grindeks, Latvia), an inhibitor of l-carnitine biosynthesis pathway via the inhibition of γ-butyrobetaine dioxygenase, is used for the treatment of myocardial ischemia in Eastern Europe and has shown a neuroprotective effect in several stroke models. Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats even though the infarct size did not decrease (Svalbe et al 2011). Analysis of cerebellar tissue extracts revealed significant decrease of concentration of l-carnitine and increase of γ-butyrobetaine. Russian studies have reported efficacy of the mildronate in treatment of patients with ischemic stroke. A randomized, double-blind, placebo-controlled phase II clinical trial in ischemic stroke patients is ongoing at the Xijing Hospital in China (ClinicalTrials. gov Identifier: NCT01800357).

Mode of action

Mildronate is a cardioprotective drug, the main mechanism of action of Mildronate is based on carnitine biosynthesis inhibition aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process.

76144-82-6
76144-81-5
Synthesis of Mildronate from Hydrazinium,2-(3-methoxy-3-oxopropyl)-1,1,1-trimethyl-, chloride (1:1)

Mildronate Preparation Products And Raw materials

Global( 254)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 873 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 990 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838 evan@tyvovo.com China 146 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55

Related articles

View Lastest Price from Mildronate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mildronate pictures 2024-03-26 Mildronate
76144-81-5
US $0.00 / Kg/Bag 2Kg/Bag 99% up /EP 20 tons Sinoway Industrial co., ltd.
Mildronate pictures 2023-11-27 Mildronate
76144-81-5
US $280.00 / KG 1KG 99% HPLC 20 TONS Wuhan Senwayer Century Chemical Co.,Ltd
Meldonium pictures 2023-11-01 Meldonium
76144-81-5
US $0.00-0.00 / kg 0.10000000149011612kg 99.0%min 200kg Hangzhou ICH Biofarm Co., Ltd
  • Mildronate pictures
  • Mildronate
    76144-81-5
  • US $0.00 / Kg/Bag
  • 99% up /EP
  • Sinoway Industrial co., ltd.
  • Mildronate pictures
  • Mildronate
    76144-81-5
  • US $280.00 / KG
  • 99% HPLC
  • Wuhan Senwayer Century Chemical Co.,Ltd
  • Meldonium pictures
  • Meldonium
    76144-81-5
  • US $0.00-0.00 / kg
  • 99.0%min
  • Hangzhou ICH Biofarm Co., Ltd

Mildronate Spectrum

Mildronate 3-(2,2,2-Trimethylhydrazine)propionate 3-(trimethylammonioamino)propionate 3-(trimethylazaniumylamino)propanoate 3-(2,2,2-trimethyldiazan-2-iumyl)propanoate dihydrate Kvaterin 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt 3-(2,2,2-trimethylhydrazine)propionate MILDRONATE Mildonate 3-(2,2,2-Trimethylhydrazinium)propionate Meldomiun MET88 Quateri 3-(trimethylammonioamino)propanoate Quaterin 1,1,1-Trimethylhydrazinium 2-propionate 2-(2-Carboxylatoethyl)-1,1,1-trimethylhydrazinium 3-[(Trimethylaminio)amino]propionic acidanion N-Trimethyl-hydrazine-3-propionate Mildronate,MeldoniuM Mildronate API Mildronate inject grade Mildronate inject or Oral Mildronate USP/EP/BP Mildronate powder MildronateQ: What is Mildronate Q: What is the CAS Number of Mildronate Q: What is the storage condition of Mildronate Mildrote 3-(2,2,2-triMethylhydraziniuM)propionate dehydrate 2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt 2H3]-Mildronate HCl 76144-81-5 C6H18N2O4 Cardiovascular Pharmaceutical intermediate Intermediates & Fine Chemicals Pharmaceuticals Pharma raw material