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Ethyl cyanoacetate

Ethyl cyanoacetate
Ethyl cyanoacetate structure
CAS No.
105-56-6
Chemical Name:
Ethyl cyanoacetate
Synonyms
ECYA;CL079;usafkf-25;USAF kf-25;NCCH2COOC2H5;Cyanessigester;Ethylcyanacetat;Ethylcyanoacetat;ethylcyanacetate;2-cyanobutanoate
CBNumber:
CB9852660
Molecular Formula:
C5H7NO2
Formula Weight:
113.11
MOL File:
105-56-6.mol

Ethyl cyanoacetate Properties

Melting point:
-22 °C
Boiling point:
208-210 °C(lit.)
Density 
1.063 g/mL at 25 °C(lit.)
vapor density 
3.9 (vs air)
vapor pressure 
1 mm Hg ( 67.8 °C)
refractive index 
n20/D 1.418(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
20g/l
form 
Liquid
color 
Clear
Water Solubility 
20 g/L (20 ºC)
Merck 
14,3786
BRN 
605871
CAS DataBase Reference
105-56-6(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, cyano-, ethyl ester(105-56-6)
EPA Substance Registry System
Acetic acid, cyano-, ethyl ester(105-56-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/38
Safety Statements  36/37-37/39-26
RIDADR  3276
WGK Germany  1
RTECS  AG4110000
10
Autoignition Temperature 460 °C
TSCA  Yes
HS Code  2926 90 70
Hazardous Substances Data 105-56-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Ethyl cyanoacetate price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E18425 Ethyl cyanoacetate ≥98% 105-56-6 5g $32.6 2018-11-13 Buy
Sigma-Aldrich E18425 Ethyl cyanoacetate ≥98% 105-56-6 1kg $86.5 2018-11-13 Buy
TCI Chemical C0441 Ethyl Cyanoacetate >99.0%(GC) 105-56-6 25g $16 2018-11-22 Buy
TCI Chemical C0441 Ethyl Cyanoacetate >99.0%(GC) 105-56-6 500g $42 2018-11-22 Buy
Alfa Aesar A11498 Ethyl cyanoacetate, 98+% 105-56-6 500g $43.6 2018-11-13 Buy

Ethyl cyanoacetate Chemical Properties,Uses,Production

Chemical Properties

clear liquid

Chemical Properties

Ethyl cyanoacetate is a colorless to straw colored liquid with a mild pleasant odor

Uses

Reagent used in labelled pyrimidine and purine synthesis.

General Description

A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 210°F. May be toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Ethyl cyanoacetate is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Hazard

Toxic by ingestion and inhalation.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

oison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Combustible when exposed to heat or flame; can react with oxidzing materials. Wdl react with water or steam to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN-. See also NITRILES.

Potential Exposure

A nitrile used to manufacture dyes, pharmaceuticals, and other chemicals.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately.If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Purification Methods

Shake the ester several times with aqueous 10% Na2CO3, wash it well with water, dry with Na2SO4 and fractionally distil it. [Beilstein 2 IV 1889.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Reacts with moisture, water, and steam, forming toxic fumes.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Ethyl cyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

5-CYANO-6-HYDROXY-4-METHOXYMETHYL-2-METHYLPYRIDINE ETHYL 2-CYANO-3-METHYL-2-PENTENOATE ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Triamterene 2-(4,6-diamino-1,3,5-triazin-2-yl)acetic acid Allopurinol 2-Amino-4-trifluoromethylbenzonitrile 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER 1-ETHYL-1-METHYLSUCCINIC ACID Disperse Yellow S-3GL 6-AMINO-2-METHYLTHIO-3-METHYLURACIL 1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE 6-Aminouracil 2-CHLORO-4-METHYLQUINOLINE-3-CARBONITRILE ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 6-AMINO-2-MERCAPTO-PYRIMIDIN-4-OL Ethyl α-cyanoacrylate instantaneous adhesive 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 3-AMINO-2,2-DIMETHYL-1-PROPANOL 2-AMINO-5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Amiloride hydrochloride 5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 6-Amino-1-methyluracil 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE 6-CHLORO-5-CYANO-4-METHOXYMETHYL-3-NITRO-2-PICOLINE 4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE GUANINE SULFATE Dacarbazine 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 6-AMINO-1-METHYL-5-NITROSOURACIL 6-AMINO-3-METHYLURACIL Ethyl 3-ethoxy-3-iminopropionate hydrochloride 5,6-Diamino-1-methyluracil

Ethyl cyanoacetate Suppliers

Global( 265)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
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86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
Xiamen AmoyChem Co., Ltd
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Hubei Jusheng Technology Co.,Ltd.
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Jinan Finer Chemical Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182;18626450290
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Nanjing Xiezun Chemical Co., Ltd. 025-85629050 13912997845
025-85629050 tian_zun@126.com China 38 60

Ethyl cyanoacetate Spectrum


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