2-Chloropyridine
- CAS No.
- 109-09-1
- Chemical Name:
- 2-Chloropyridine
- Synonyms
- 2CLPY;NSC 4649;2-Chloropyridi;2-CHLOROPYRIDINE;α-chloropyridine;o-Chloropyridine;2-chloro-pyridin;2- chlorinepyridine;Pyridine, 2-chloro-;TAK438 Impurity 135
- CBNumber:
- CB9852776
- Molecular Formula:
- C5H4ClN
- Molecular Weight:
- 113.54
- MDL Number:
- MFCD00006228
- MOL File:
- 109-09-1.mol
| Melting point | -46 °C |
|---|---|
| Boiling point | 166 °C/714 mmHg (lit.) |
| Density | 1.2 g/mL at 25 °C (lit.) |
| vapor pressure | 1.7 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 149 °F |
| storage temp. | Refrigerator |
| solubility | 27g/l |
| form | Liquid |
| pka | 0.49(at 25℃) |
| color | Clear colorless to light yellow |
| PH | 6-7 (27g/l, H2O, 20℃) |
| Water Solubility | 27 g/L (20 ºC) |
| BRN | 105788 |
| CAS DataBase Reference | 109-09-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8HMD45AYEJ |
| NIST Chemistry Reference | Pyridine, 2-chloro-(109-09-1) |
| EPA Substance Registry System | 2-Chloropyridine (109-09-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H310+H330-H315-H318-H335-H373-H410 | |||||||||
| Precautionary statements | P262-P273-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-28A-27 | |||||||||
| RIDADR | UN 2822 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US5950000 | |||||||||
| Hazard Note | Toxic | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
2-Chloropyridine Chemical Properties,Uses,Production
Chemical Properties
Clear colourless to light yellow liquid
Uses
2- Chloropyridine is used as an intermediate chemical in the production of various pyrithione, for use in cosmetics, personal care products and pharmaceutical products.
Uses
2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during t he decomposition of specific insecticides.
Definition
ChEBI: 2-chloropyridine is a monochloropyridine.
Synthesis Reference(s)
Synthetic Communications, 19, p. 897, 1989 DOI: 10.1080/00397918908051009
Synthesis, p. 337, 1990
General Description
A colorless oily liquid. Toxic by ingestion and/or skin absorption. Used to make other chemicals.
Air & Water Reactions
Slightly soluble in water and denser than water.
Hazard
Toxic by ingestion.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Safety Profile
Poison by ingestion, inhalation, skin contact, and intraperitoneal routes. Combustible when exposed to heat or flame. Can react with oxidizing materials. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and phosgene.
Purification Methods
Dry 2-chloropyridine with NaOH for several days, then distil it from CaO under reduced pressure. [Beilstein 20/5 V 402.]
2-Chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of4