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Furan

Chemical Properties Raw material for organic synthesis Uses Production method Category Toxicity grading Acute toxicity Explosive and Hazardous characteristics Flammability and hazard characteristics Storage characteristics Extinguishing agent Professional Standards
Furan
Furan structure
CAS No.
110-00-9
Chemical Name:
Furan
Synonyms
ACF;OXOL;axole;Oxole;FURAN;tetrol;Furane;Pyrane;Tetrole;furan00
CBNumber:
CB9852796
Molecular Formula:
C4H4O
Formula Weight:
68.07
MOL File:
110-00-9.mol

Furan Properties

Melting point:
-85.6 °C
Boiling point:
67 °C10 mm Hg(lit.)
Density 
0.936 g/mL at 25 °C(lit.)
vapor density 
2.35 (vs air)
vapor pressure 
1672 mm Hg ( 55 °C)
refractive index 
n20/D 1.5070(lit.)
Flash point:
160 °F
storage temp. 
2-8°C
solubility 
alcohols: freely soluble
form 
Liquid
color 
Clear colorless to yellow
explosive limit
2.3-14.3%(V)
Water Solubility 
insoluble
Sensitive 
Air & Light Sensitive
Merck 
14,4296
BRN 
103221
Stability:
Stable. Substances to be avoided include strong oxidising agents, acids, peroxides and oxygen. Highly flammable; can form explosive mixtures with air.
InChIKey
YLQBMQCUIZJEEH-UHFFFAOYSA-N
CAS DataBase Reference
110-00-9(CAS DataBase Reference)
NIST Chemistry Reference
Furan(110-00-9)
EPA Substance Registry System
Furan(110-00-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H224-H302+H332-H315-H341-H350-H373-H412-H302-H332
Precautionary statements  P260-P303+P361+P353-P405-P501a-P201-P210-P273-P281-P308+P313
Hazard Codes  T,F+
Risk Statements  45-12-19-20/22-38-48/22-52/53-68
Safety Statements  53-45-61-
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  OB3870000
8-9-23
Autoignition Temperature 390 °C
TSCA  Yes
HSCode  2932 19 00
HazardClass  3
PackingGroup  I
Toxicity LC (in air) in rats: 30400 ppm (Henderson)

NFPA 704

Diamond Hazard Value Description
4
2 1
Health   2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
Flammability   4 Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
Special  

(NFPA, 2010)

Furan price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 185922 Furan ≥99% 110-00-9 100ml $20.1 2018-11-20 Buy
Sigma-Aldrich 185922 Furan ≥99% 110-00-9 5ml $26.5 2018-11-20 Buy
TCI Chemical F0074 Furan (stabilized with BHT) >99.0%(GC) 110-00-9 25mL $12 2018-11-22 Buy
TCI Chemical F0074 Furan (stabilized with BHT) >99.0%(GC) 110-00-9 500mL $54 2018-11-22 Buy
Alfa Aesar A13102 Furan, 99%, stab. with ca 250ppm BHT 110-00-9 500ml $70.4 2018-11-13 Buy

Furan Chemical Properties,Uses,Production

Chemical Properties

Furan is the simplest five membered oxygen-containing heterocyclic compounds with its molecular structure containing ring diene ether. It belongs to 6π electron-based compound with all the 5 atoms being sp2-hybrid and located in the same plane. The pair of non-shared electrons of the oxygen atoms occupied p-orbital which is perpendicular to the ring plane and is parallel and overlapping with the p-orbital of the four carbons atoms, forming a five-atoms& six-electrons conjugated closed system. Therefore, it has a certain degree of aromatic nature. However, due to the electron density on the ring is not as uniform as benzene; it has a more active chemical property than benzene and can participate in many kinds of chemical reactions. It should be especially noted that, its 2, 5-position contains high electron density and prone to have nucleophilic substitution reaction. Moreover, all the derivatives of almost happens in 2-position such as furfural, furfuryl alcohol and furan carboxylic acid. Furan can also have nitrification, halogenated, sulfonated reaction. Its diene bonds can also participate in addition reaction, for example, have reaction with maleic anhydride, having diene addition reaction and generating 7-bicyclo-[2.2.1]-hept-5-ene-2, 3-dicarboxylic anhydride.
Under acidic condition, furan can have hydrolysis and ring open, producing 1, 4-dicarbonyl compounds. But once the furan ring has been introduced of electrophilic group, its activity can be greatly reduced and will not have diene reaction even encountering strong pro-diene compound. Although it contains certain aromatic property, but this property is very weak and there are no free hydroxyl furan or amino furan like phenol and aniline. When furan is subject to hydrogenation, it can give rise to two kinds of hydrides, namely dihydrofuran (2, 3-dihydrofuran and 2, 5-dihydrofuran) and tetrahydrofuran with the former being partially saturated cyclic enol ether and the later being saturated. Furan has a high thermal stability and is decomposed only at a temperature as high as 670 ℃ in the absence of catalyst. In the presence of a nickel catalyst, it is decomposed when heated to 360 ℃. This product is toxic and carcinogenic. The lethal concentration for Rat through oral administration is 300mg/kg. Its steam is narcotic which is similar as ether. It is easy to generate explosive peroxides in air.
Its steam encounters pine wood chip pre-soaked with hydrochloride tablets and generate green color (pine wood chip reaction). This can be used to identify the presence of furan.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Raw material for organic synthesis

Furan is an important raw material in organic synthesis industry and can be used in the manufacture of many kinds of industrial chemical product such as pyrrole, thiophene tetrahydrofuran and benzofuran. It can also be applied to the manufacture of drugs such as anisodamine, atropine, toluoyl pyrrole sodium acetate, thiamine furan and furadantin and so on. Furan, through oxidation and polymerization, can generate conductive poly-furan polymer with the conductivity being 18S/m (use AsF5 as the oxidant) or 2.2 × 10-4S/m (with NOSbF6 as the oxidant). Furan is unstable and prone to be subject to oxidation and polymerization. Furan, via catalytic hydrogenation, can generate tetrahydrofuran.
Many furan derivatives are drugs such as furfural, furfuryl alcohol, furan carboxylic acid, nitrofurazone, furapromide and furosemide and so on. In some monosaccharides such as fructose and ribose as well as their derivatives, there exists the cyclic structure of hydrogenated furans.

Uses

It is primarily used for the adhesive for the production of large quantities of hot-box technological cores.
Furan can be used as the raw material of organic synthesis and solvents. Furan can also be used for preparation of pyrrole, thiophene and tetrahydrofuran. Tetrahydrofuran is an important derivative of furan with many important applications. Furan, when undergoes etherfication and reduction to give 2, 5-dimethoxy dihydrofuran which is further converted to 2-hydroxy-1, 4-butanedial through hydrolysis, can be used for the production of anisodamine via synthetic approach; When furan undergoes etherfication and reduction to give 2, 5-dimethoxy tetrahydrofuran and generate butanedial via hydrolysis, is the raw material for synthesis of another kind of alkaloid, atropine. Furan is also used to produce anti-inflammatory drugs toluoyl pyrrole sodium acetate with production of each ton of this product consuming 4.75 t of furan.

Production method

Furfural is oxidized into 2-furan formic acid which undergoes decarboxylation to obtain furans. Heat the 2-furan formic acid to 200-205 ℃ (around the boiling point) so it is decomposed into carbon dioxide and furans. During the reaction process, send the sublimated 2-furan formic acid back to the reactor with the distilled furan undergoing re-distillation; collect the distillation fraction of 31-34 ℃ which is the relative pure finished product with the overall yield being about 75%. Industrially, it can be obtained through direct decarbonylation of furfural. The catalyst used in the reaction includes aluminum silicate, metal oxides or hydroxides as well as the mixtures of alloy or metals such as the mixture of zinc chromite and manganese. The reaction temperature should be about 400 ℃ with the yield being 90%. For large-scale production, the yield can be 74%.

Category

Flammable liquid

Toxicity grading

poisoning

Acute toxicity

Inhalation-rat LC50: 3398 PPM/per hour; Inhalation-Mouse LC50: 120 mg/m3/per hour.

Explosive and Hazardous characteristics

Mixing with air can be explosive.

Flammability and hazard characteristics

It is flammable in case of fire, high temperature and oxidant with burning releasing irritated fume.

Storage characteristics

Treasury ventilation low-temperature and dry; store it separately from oxidants and acids.

Extinguishing agent

Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent

Professional Standards

TLV-TWA 0.5 mg/m3

Chemical Properties

Furan is a cyclic dienic ether stabilized by benzene-like resonance. Because of its conjugated unsaturation and heterocyclic atom, furan will undergo many types of reactions. It is, therefore, of interest as a chemical intermediate for pharmaceuticals, insecticides and fine chemicals. The heterocyclic oxygen atom in a ring with conjugated unsaturation gives furan a combination of ether, aromatic and olefinic characteristics. This polyfunctionality permits it to undergo a variety of reactions. Compared to benzene, the furan ring has greater reactivity, and is more susceptible to cleavage, thus resembling the vinyl ethers. Like the vinyl ethers, the furan ring is cleaved by aqueous acids. This reaction is accompanied by resinification .

Chemical Properties

Furan is a colorless liquid; turns brown on standing. Strong ethereal odor.

Uses

Furan is a valuable chemical intermediate for pharmaceuticals, insecticides, and other organic compounds. The furan ring is cleaved by aqueous acid which can lead to polymer formation.

Uses

Furan is a five-membered heterocyclic aromatic ring. Furan is used as a building block for the preparation of many heterocyclic compounds.

Uses

In organic syntheses.

Uses

Furan is used as an intermediate in organicsynthesis.

Definition

A heterocyclic compound.

Definition

A heterocyclic liquid organic compound. Its five-membered ring contains four carbon atoms and one oxygen atom. The structure is characteristic of some monosaccharide sugars (furanoses).

Definition

furan: A colourless liquid compound,C4H4O; r.d. 0.94; m.p. –86°C;b.p. 31.4°C. It has a five-memberedring consisting of four CH2 groupsand one oxygen atom.

General Description

Furan is a stable, colourless chemical liquid. It is highly flammable and forms explosive mixtures with air. It is incompatible with many other chemical substances, for example, strong oxidising agents, acids, peroxides, and oxygen. Furan is produced commercially by decarbonylation of furfural. It is used mainly in the production of tetrahydrofuran, thiophene, and pyrrole. It also occurs naturally in certain woods and during the combustion of coal and is found in engine exhausts, wood smoke, and tobacco smoke.

Air & Water Reactions

Highly flammable. When uninhibited, Furan forms explosive peroxides on exposure to air. Insoluble in water.

Reactivity Profile

Furan is sensitive to heat and may turn brown upon standing. Furan may be light sensitive. When uninhibited, Furan forms explosive peroxides on exposure to air. Furan may react with oxidizers, acids, peroxides and oxygen. Furan resinifies on evaporation or when in contact with mineral acids, but Furan is stable in alkalis. .

Hazard

Flammable, dangerous fire risk, flammable limits 2–24%, forms peroxides on exposure to air. Absorbed by skin. Possible carcinogen.

Health Hazard

The vapors are narcotic. Acute exposure to Furan by inhalation may involve both reversible and irreversible changes. Acute exposure by ingestion or skin absorption, as well as chronic exposure, are associated with high toxicity.

Health Hazard

Furan is a highly toxic compound. Inhalationof its vapors can cause acute pulmonaryedema and lung damage. The intraperitonealLD50 value in rodents is between 5 and7 mg/kg. The inhalation LC50 value in micefor a 1-hour exposure is 120 mg/m3.

Fire Hazard

Very dangerous, upon exposure to heat or flame. Furan may form unstable peroxides on exposure to air. Contact with acids can initiate a violent, heat producing reaction. Avoid acids, oxidizing agents. Upon standing in air, Furan may form unstable peroxides.

Safety Profile

Confirmed carcinogen. Poison by inhalation and intraperitoneal routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. A narcotic. Mutation data reported. The exposure concentration limit of 10 ppm together with its low boiling point requires that adequate ventilation be provided in areas where ths chemical is handled. Contact with liquid must be avoided since this chemical can be absorbed through the skin. Washing thoroughly with soap and water followed by prolonged rinsing should be done immedlatelp after accidental contact. A very dangerous fire hazard when exposed to heat or flame; can react with oxidzing materials. Unstabdized, it may form unstable peroxides on exposure to air and should always be tested before ddlation. Washing with an aqueous solution of ferrous sulfate slightly acidified with sodum bisulfate will remove these peroxides. Confirm by test. Contact with acids can initiate a violent exothermic reaction. Moderate explosion hazard when exposed to flame. Furan's low bohg point makes it easy to obtain explosive concentrations of the vapor in inadequately ventilated areas. To fight fire, use CO2, dr). chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also PEROXIDES.

Potential Exposure

Furan is used as a chemical intermedi ate in the production of herbicides and pharmaceuticals; for making tetrahydrofuran; in formation of lacquers; as a sol vent for resins in organic synthesis, especially for pyrrole, thiophene.

Carcinogenicity

Furan is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2389 Furan, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Shake it with aqueous 5% KOH, dry it with CaSO4 or Na2SO4, then distil it under nitrogen, from KOH or sodium, immediately before use. A trace of hydroquinone could be added as an inhibitor of oxidation. [Beilstein 17 H 27, 17 I 16, 17 II 34, 17/1 V 291.]

Incompatibilities

May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, amines, strong bases, reducing agents. Unless stabilized with an inhibitor, air exposure forms unstable peroxides.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern ing storage, transportation, treatment, and waste disposal.

Regulations

Department of Transportation (DOT)
Furan is considered a hazardous material, and special requirements have been set for marking, labeling, and transporting this material.
Environmental Protection Agency (EPA)
Clean Air Act
Prevention of Accidental Release: Threshold quantity (TQ) = 5,000 lb.
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 100 lb.
Emergency Planning and Community Right-To-Know Act
Reportable quantity (RQ) = 100 lb. Threshold planning quantity (TPQ) = 500 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of furan = U124.
Occupational Safety and Health Administration (OSHA)
Considered a highly hazardous chemical; threshold quantity (TQ) = 500 lb.

Furan Preparation Products And Raw materials

Raw materials

Preparation Products


Furan Suppliers

Global( 146)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 146 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Jiangsu Qingquan Chemical Co., Ltd. +86-571-86589381
+86-571-86589380 sales@qqpharm.com China 146 71
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30163 84

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