ChemicalBook
Chinese Japanese Germany Korea

2-Phenoxyethanol

2-Phenoxyethanol
2-Phenoxyethanol structure
CAS No.
122-99-6
Chemical Name:
2-Phenoxyethanol
Synonyms
PhG;Arosol;dowanolep;emery6705;Dowanol EP;dowanoleph;Emery 6705;Phenoxytol;arosol[qr];PHENOXETOL
CBNumber:
CB9852958
Molecular Formula:
C8H10O2
Formula Weight:
138.16
MOL File:
122-99-6.mol

2-Phenoxyethanol Properties

Melting point:
11-13 °C
Boiling point:
247 °C(lit.)
Density 
1.107 g/mL at 20 °C(lit.)
vapor density 
4.8 (vs air)
vapor pressure 
0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.539
FEMA 
4620 | 2-PHENOXYETHANOL
Flash point:
>230 °F
storage temp. 
room temp
solubility 
soluble, clear, colorless to very faintly yellow
form 
Liquid
color 
Clear colorless
Specific Gravity
1.109 (20/4℃)
PH
7 (10g/l, H2O, 23℃)
explosive limit
1.4-9.0%(V)
Water Solubility 
30 g/L (20 ºC)
Merck 
14,7257
BRN 
1364011
InChIKey
QCDWFXQBSFUVSP-UHFFFAOYSA-N
CAS DataBase Reference
122-99-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Phenoxyethanol(122-99-6)
EPA Substance Registry System
Ethanol, 2-phenoxy-(122-99-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn,Xi
Risk Statements  22-36-R36-R22
Safety Statements  26-S26
WGK Germany  1
RTECS  KM0350000
Autoignition Temperature 535 °C DIN 51794
Hazard Note  Irritant
TSCA  Yes
HS Code  29094990
Hazardous Substances Data 122-99-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

2-Phenoxyethanol price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 484318 Ethylene glycol monophenyl ether ≥90% 122-99-6 1l $45.8 2018-11-13 Buy
Sigma-Aldrich 1526200 Phenoxyethanol United States Pharmacopeia (USP) Reference Standard 122-99-6 500mg $386 2018-11-13 Buy
TCI Chemical P0115 2-Phenoxyethanol >98.5%(GC) 122-99-6 25g $14 2018-11-22 Buy
TCI Chemical P0115 2-Phenoxyethanol >98.5%(GC) 122-99-6 500g $22 2018-11-22 Buy
Alfa Aesar A10786 2-Phenoxyethanol, 94% 122-99-6 250g $18.7 2018-11-13 Buy

2-Phenoxyethanol Chemical Properties,Uses,Production

Description

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

Chemical Properties

clear colorless liquid

Chemical Properties

Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.

Characteristics

Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

Uses

phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.

Uses

Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.

Uses

Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

Uses

Antimicrobial preservative; also used topically in treatment of bacterial infections.

Production Methods

Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

General Description

Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

Air & Water Reactions

Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

Reactivity Profile

2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

Health Hazard

May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

Fire Hazard

2-Phenoxyethanol is combustible.

Pharmaceutical Applications

Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

Industrial uses

2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

Contact allergens

Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

Safety

Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD50 (rabbit, skin): 5 g/kg
LD50 (rat, oral): 1.26 g/kg

storage

Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

2-Phenoxyethanol Preparation Products And Raw materials

Raw materials

Preparation Products


2-Phenoxyethanol Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 746 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58

View Lastest Price from 2-Phenoxyethanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-03 2-Phenoxyethanol in stock Factory
122-99-6
US $1.00 / KG 1KG TOP 3 Factory in China Top 3 production capacity Factory Chemwill Asia Co.,Ltd.
2018-12-17 2-Phenoxyethanol
122-99-6
US $1.00 / kg 1kg 99% 100KG career henan chemical co

2-Phenoxyethanol Spectrum


122-99-6(2-Phenoxyethanol)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved