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Pyrrolidine Chemical Properties Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent Occupational standards
Pyrrolidine structure
Chemical Name:
PRD;PRL;NSC 62781;Azolidine;Prolamine;FEMA 2523;FEMA 3523;Lutetropin;Pyrrolidin;PYRROLIDINE
Molecular Formula:
Formula Weight:
MOL File:

Pyrrolidine Properties

Melting point:
-63 °C
Boiling point:
87-88 °C(lit.)
vapor density 
2.45 (vs air)
vapor pressure 
128 mm Hg ( 39 °C)
refractive index 
n20/D 1.443(lit.)
Flash point:
37 °F
storage temp. 
Flammables area
water: miscible
11.27(at 25℃)
12.9 (100g/l, H2O, 20℃)
explosive limit
Water Solubility 
Miscible with alcohol, ether, chloroform and water.
Air Sensitive
JECFA Number
Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference
123-75-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H301-H318-H332-H225-H302+H332-H314
Precautionary statements  P301+P310a-P303+P361+P353-P405-P501a-P210-P280-P305+P351+P338-P310
Hazard Codes  F,T,C
Risk Statements  11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11
Safety Statements  16-26-36/37/39-45-33-S45-S36/37/39-S26-S16
RIDADR  UN 1922 3/PG 2
WGK Germany  2
RTECS  UX9650000
Autoignition Temperature 653 °F
HS Code  2933 99 80
HazardClass  3
PackingGroup  II
Toxicity LD50 orally in Rabbit: 433 mg/kg

NFPA 704

Diamond Hazard Value Description
2 1
Health   2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)

(NFPA, 2010)

Pyrrolidine price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 394238 Pyrrolidine ≥99.5%, purified by redistillation 123-75-1 100ml $42.1 2018-11-13 Buy
Sigma-Aldrich 394238 Pyrrolidine ≥99.5%, purified by redistillation 123-75-1 1l $266 2018-11-13 Buy
TCI Chemical P0576 Pyrrolidine >98.0%(GC) 123-75-1 25mL $14 2018-11-22 Buy
TCI Chemical P0576 Pyrrolidine >98.0%(GC) 123-75-1 500mL $56 2018-11-22 Buy
Alfa Aesar A14852 Pyrrolidine, 99% 123-75-1 500ml $64.3 2018-11-13 Buy

Pyrrolidine Chemical Properties,Uses,Production


Pyrrolidine is also known as tetrahydro pyrrole, and it is colorless to pale yellow liquid with a pungent ammonia odor, smoke in air, and toxic. The relative density is 0.8618, the boiling point is 88~89℃, refractive index is 1.4402 (28℃). It is strong alkaline, miscible with water, soluble in alcohol, ether and chloroform.
Pyrrole can synthesize pyrrolidine by catalytic hydrogenation, pyrrolidine present in tobacco and carrot leaves, and it is natural substances, the molecular structure of pyrrolidine is cyclic secondary amine, which is generally the same with the reaction of amine. Pyrrolidine is an important organic chemical raw material, it can be used for drug preparation, fungicides and insecticides.
1. 1,4-butanediol as the raw material, dehydrate to tetrahydrofuran, and then reacte with ammonia, then pyrrolidine can be obtained.
2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole.
3. The 1,4-dichloro-butane as raw material, react with ammonia, pyrrolidine can be obtained.
4. Pyrrole as raw material, with the catalyst of rhodium or ruthenium, with the reaction of reduction can obtain .
The above information is edited by the chemicalbook of Wang Xiaodong.

Chemical Properties

It is colorless, transparent liquid with special smell. When exposed to light or moist air, it can turn yellow. It can be soluble in water, ethanol. It is corrosive and flammable. Boiling point is 87.0~89.0℃.


Pharmaceutical raw materials, organic synthesis, special organic solvents.
It can be used for the preparation of drugs, fungicides, insecticides, etc.


Flammable liquid.

Toxicity grading

Highly toxic.

Acute toxicity

Oral-rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg.

Flammability hazard characteristics

When exposed to fire, high temperature, oxidant, it is flammable; when heat, toxic nitric oxide gas can produce.

Storage Characteristics

Treasury ventilation low-temperature drying; oxidants, acids stored separately.

Extinguishing agent

Dry, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Occupational standards

STEL 0.1 mg /m.

Chemical Properties

colourless to pale yellow liquid with a penetrating

Chemical Properties

Pyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is nauseating and diffusive


Reported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.


Uses of this compound in any major scalehave not been made. It occurs in tobacco andcarrot leaves. It is formed by reduction ofpyrrole.


A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).


ChEBI: A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.


Via overall 5-endo-trig cyclizations of homoallylic tosylamides.


pyrrolidine: A saturated heterocycliccompound having one nitrogenatom in a five-membered ring,C4H9N; r.d. 0.87; m.p. –63°C b.p.87°C. It is found in certain plants andthe ring structure is present in manyalkaloids.

Aroma threshold values

Detection: 20.2 ppm

Taste threshold values

Taste characteristics at 50 ppm: ammonia and fishy, amine-like with seaweed and shellfish nuances.

General Description

A colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

Air & Water Reactions

Highly flammable. Very soluble in water.

Reactivity Profile

Tetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.


Flammable, dangerous fire risk. Toxic by ingestion and inhalation.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Health Hazard

The acute toxicity of pyrrolidine is moderateon test animals. It is somewhat less toxicthan pyrrole. The vapors are an irritant tothe eyes and respiratory tract. The liquid iscorrosive to the skin. Contact with the eyescan cause damage. The oral LD50 value inrats is 300 mg/kg, while the inhalation LC50value in mice is 1300 mg/m3/2 h (NIOSH1986).

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.

Purification Methods

Dry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]

Pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrrolidine Suppliers

Global( 315)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Yunbio Tech Co.,Ltd.
010-60605551 CHINA 255 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 2314 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19918 60
Henan DaKen Chemical CO.,LTD.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 CHINA 1817 55
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0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
career henan chemical co
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View Lastest Price from Pyrrolidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-17 Pyrrolidine
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD
2019-10-17 pyrrolidine
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD
2019-08-14 pyrrolidine
US $1.00 / g 1g 99% 1000kg Cangzhou Wanyou New Material Technology Co.,Ltd

Pyrrolidine Spectrum

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