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Cyanogen bromide

Cyanogen bromide
Cyanogen bromide structure
CAS No.
506-68-3
Chemical Name:
Cyanogen bromide
Synonyms
BrCN;tl822;(CN)Br;TL 822;Cyanog;Bromcyan;Campilit;BROMOCYAN;NSC 89684;BROMOCYANE
CBNumber:
CB9853692
Molecular Formula:
CBrN
Formula Weight:
105.92
MOL File:
506-68-3.mol

Cyanogen bromide Properties

Melting point:
50-53 °C (lit.)
Boiling point:
61-62 °C (lit.)
Density 
1.443 g/mL at 25 °C
vapor density 
3.65 (vs air)
vapor pressure 
100 mm Hg ( 22.6 °C)
refractive index 
1.4670 (estimate)
Flash point:
61.4°C
storage temp. 
2-8°C
solubility 
Soluble in chloroform, dichloromethane, ethanol, diethyl ether, benzene and acetonitrile.
form 
Solution
color 
White
Odor
Penetrating odor
Water Solubility 
decomposed slowly by cold H2O [HAW93]
Sensitive 
Moisture & Light Sensitive
Merck 
14,2693
BRN 
1697296
Exposure limits
No exposure limit is set. However, on the basis of the exposure limits of related compounds a ceiling limit of 0.5 ppm (2 mg/m3) is recommended.
Stability:
Stable. Reacts violently with water and with mineral and organic acids.
CAS DataBase Reference
506-68-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
OS382OHJ8P
NIST Chemistry Reference
Cyanogen bromide(506-68-3)
EPA Substance Registry System
Cyanogen bromide (506-68-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS02,GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H300+H330-H311-H314-H336-H351-H225-H300+H310+H330-H400-H300-H310-H330-H410
Precautionary statements  P301+P310a-P304+P340-P320-P405-P501a-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P210-P370+P378-P403+P235
Hazard Codes  T+,N,F,C
Risk Statements  26/27/28-34-50/53-40-11-36/37-32-51/53
Safety Statements  53-28-36/37/39-45-60-61-26-16-7/9-29-7
RIDADR  UN 3390 6.1/PG 1
WGK Germany  3
RTECS  GT2100000
8-17-19-21
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  28530090
Toxicity LCLO inhal (human) 92 ppm (398 mg/m3; 10 min)
LCLO inhal (mouse) 115 ppm (500 mg/m3; 10 min)
NFPA 704
0
4 1

Cyanogen bromide price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 341894 Cyanogen bromide solution 3.0M in methylene chloride 506-68-3 100ml $87.3 2021-03-22 Buy
Sigma-Aldrich 261610 Cyanogen bromide solution 5.0M in acetonitrile 506-68-3 100ml $87.6 2021-03-22 Buy
Alfa Aesar 032731 Cyanogen bromide 506-68-3 5g $27.3 2021-03-22 Buy
Alfa Aesar 032731 Cyanogen bromide 506-68-3 25g $54.4 2021-03-22 Buy
Strem Chemicals 93-1001 Cyanogen bromide, min. 97% 506-68-3 100g $143 2021-03-22 Buy

Cyanogen bromide Chemical Properties,Uses,Production

Chemical Properties

white crystalline solid

Chemical Properties

Cyanogen bromide is a colorless or white, volatile, crystalline solid with a penetrating odor.

Uses

Reaction with C60Ph5Cl produces a novel phenylated isoquinolino[3′,4′:1,2][60]fullerene.1

Uses

Reagent for the synthesis of cyanamides.

Uses

Cyanogen bromide is used in organic synthesis and as a reagent in bioanalysis.

Production Methods

Cyanogen bromide may be prepared by either the action of bromine on potassium cyanide or the interaction of sodium bromide, sodium cyanide, sodium chlorate, and sulfuric acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2102, 1946 DOI: 10.1021/ja01214a501

General Description

Cyanogen bromide is a colorless to white crystalline solid with a penetrating odor. Cyanogen bromide is slightly soluble in water. Cyanogen bromide is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a flammable and poisonous gas. Contamination with many materials can cause rapid decomposition of the material. Cyanogen bromide is toxic by inhalation of its vapors or by the hydrogen cyanide from decomposition or by ingestion. Toxic oxides of nitrogen are produced in fire involving Cyanogen bromide. Cyanogen bromide is used in gold extraction, to make other chemicals, and as a fumigant.

Air & Water Reactions

Cyanogen bromide is slightly soluble in water. Cyanogen bromide is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a poison gas.

Reactivity Profile

Cyanogen bromide is not combustible itself, but impure Cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. [EPA, 1998]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).

Health Hazard

Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. Vapors are highly irritant and very poisonous. Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects.

Health Hazard

Exposure to cyanogen bromide is dangerous. The chemical substance is poisonous and causes fatal injury if swallowed, inhaled, or absorbed through the skin. It is corrosive and the vapors cause severe irritation to the eyes and respiratory tract, and cause burns to any area of contact. On contact with acids, cyanogen bromide liberates poisonous gas, affecting the blood, cardiovascular system, CNS, and thyroid.

Health Hazard

The acute toxicity of cyanogen bromide is high. Toxic effects are similar to but not as severe as those of hydrogen cyanide. Toxic symptoms may include cyanosis, nausea, dizziness, headache, lung irritation, chest pain, and pulmonary edema, which may be fatal.
Cyanogen bromide may cause chronic pulmonary edema.

Health Hazard

Cyanogen bromide is a highly toxic substance. Its toxic effects are similar to those of HCN. However, it is not as toxic as HCN. Because it volatilizes readily at ambient temperature, inhalation is the major toxic route. The toxic symptoms in humans may be nausea, headache, and chronic pulmonary edema. Exposure to 100 ppm for 10 minutes can be fatal to humans.
LC50 inhalation (mice): 500 mg/m3/10 min
Cyanogen bromide is an irritant.

Fire Hazard

Cyanogen bromide is noncombustible. Impure material decomposes rapidly and can be explosive.

Fire Hazard

Cyanogen bromide is not combustible itself, but impure Cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Vapors are highly irritating. When material is heated to decomposition, Cyanogen bromide emits very toxic fumes of cyanide and bromide. Avoid water, acids. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control.

Flammability and Explosibility

Cyanogen bromide is noncombustible. Impure material decomposes rapidly and can be explosive.

Safety Profile

A human and experimental poison by inhalation. Corrosive. When heated to decomposition it emits very toxic fumes of CNand Br-. Possibly unstable. See also other cyanogen entries; CYANIDE; and BROMIDES.

Potential Exposure

Used as an activating reagent for insoluble supports for affinity absorption. In danger are those manufacturing this compound or using it in organic synthesis or as a fumigant; in textile treatment; in gold cyaniding. It may have been used as a military poison gas.

storage

work with BrCN should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. Containers of cyanogen bromide should be kept tightly sealed and stored under nitrogen in a secondary container in a refrigerator.

Shipping

UN1889 Cyanogen bromide, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. A DOT regulated marine pollutant.

Purification Methods

All operations with this substance should be performed in a very efficient fume cupboard-it is very POISONOUS and should be handled in small amounts. Fresh commercial material is satisfactory for nearly all purposes and does not need to be purified. It is a white crystalline solid with a strong cyanide odour. If it is reddish in colour and partly liquid or paste-like, then it is too far gone to be purified, and fresh material should be sought. It can be purified by distillation using small amounts at a time, and using a short wide-bore condenser because it readily solidifies to a crystalline white solid which may clog the condenser. An appropriate gas mask should be used when transferring the molten solid from one container to another, and the operation should be done in an efficient fume cupboard. The melting point (m 49-51o) should be measured in a sealed tube. [Hartman & Dreger Org Synth Coll Vol II 150 1948.]

Incompatibilities

May be unstable unless dry and pure; impure cyanogen bromide decomposes rapidly and tends to explode. Cyanogen bromide decomposes violently on heat- ing or on contact with water, acids, or acid vapors; produc- ing highly toxic and flammable hydrogen cyanide and corrosive hydrogen bromide. Avoid physical damage, con- tact with acids or water, and store away from a location where water may be needed for fire control . Violent reaction with ammonia, amines.

Waste Disposal

May be added to strong alka- line solution of calcium hypochlorite, let stand for 24 hours and flush to sewer. May also be dissolved in flammable solvent and sprayed into an incinerator equipped with after- burner and scrubber.

Cyanogen bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Cyanogen bromide Suppliers

Global( 143)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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View Lastest Price from Cyanogen bromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-19 Cyanogen bromide
506-68-3
US $3.00 / KG 1KG 98% 1kg,5kg,50kg Career Henan Chemical Co

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