Lithium chloride

Lithium chloride Properties

Melting point	605 °C (lit.)
Boiling point	1383 °C/1 atm (lit.)
Density	2.06
vapor pressure	1.33 hPa (547 °C)
refractive index	n20/D 1.381
Flash point	-4 °F
storage temp.	2-8°C
solubility	H₂O: soluble
pka	2.256[at 20 ℃]
form	beads
Specific Gravity	2.068
color	White to gray
PH	5.5-7.5 (25℃, 50mg/mL in H2O)
Odor	Odorless
PH Range	6
Water Solubility	832 g/L (20 ºC)
Sensitive	Hygroscopic
λmax	λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01
Merck	14,5528
Stability	Stable. Incompatible with strong oxidizing agents, strong acids, bromine trichloride, bromine trifluoride. Very hygroscopic. Protect from moisture.
InChIKey	KWGKDLIKAYFUFQ-UHFFFAOYSA-M
LogP	-1
CAS DataBase Reference	7447-41-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	G4962QA067
NIST Chemistry Reference	Lithium chloride(7447-41-8)
EPA Substance Registry System	Lithium chloride (7447-41-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P264-P270-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi

Risk Statements

40-41-62-63-20/21/22 -36/37 -36/37/38 -36/38

Safety Statements

22-26-29-33-36-45-36/37-36/37/39-37/39

WGK Germany

1

RTECS

OJ5950000

F

3-10

TSCA

Yes

HS Code

28273980

Toxicity

LD50 in mice (mg/kg): 990 i.p.; in rats (mg/kg): 600 i.p., 4.8 i.v. (Wielosz).

NFPA 704

	1
2		1

Lithium chloride price More Price(140)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	73036	Lithium chloride puriss. p.a., anhydrous, ≥99.0% (AT)	7447-41-8	100g	$89.6	2024-03-01	Buy
Sigma-Aldrich	62476	Lithium chloride BioUltra, for molecular biology, anhydrous, ≥99.0% (AT)	7447-41-8	100g	$106	2024-03-01	Buy
Sigma-Aldrich	62481	Lithium chloride solution 1?M in ethanol	7447-41-8	250ML	$144	2024-03-01	Buy
Sigma-Aldrich	62476	Lithium chloride BioUltra, for molecular biology, anhydrous, ≥99.0% (AT)	7447-41-8	500g	$262	2024-03-01	Buy
Sigma-Aldrich	203637	Lithium chloride powder, ≥99.98% trace metals basis	7447-41-8	10g	$98.4	2024-03-01	Buy

Product number	Packaging	Price	Buy
73036	100g	$89.6	Buy
62476	100g	$106	Buy
62481	250ML	$144	Buy
62476	500g	$262	Buy
203637	10g	$98.4	Buy

Lithium chloride Chemical Properties,Uses,Production

Chemical Properties

Lithium chloride is a White cubic crystals; granules or powder; hygroscopic; sharp salt-like taste; melts at 605°C; vaporizes around 1360°C, It has an unusually high water solubility when compared to the other alkali metal chlorides; readily dissolves in water (64g/100mL at 0°C); also highly soluble in alcohol and pyridine; moderately soluble in acetone (4.1 g/100mL at 25°C).
The following hydrates are known: LiCl·H2O, LiCl-3H20 and LiCl- 5H2O. The higher hydrates are stable at progressively lower temperatures. Lithium chloride is deliquescent under normal atmospheric conditions.
Lithium chloride is soluble to a significant extent in many polar organic liquids. It is generally most soluble in alcohols in which the solubility decreases as the size of the organic radical increases.

It dehumidifies air for industrial drying and for air conditioning. Lithium chloride bums with a chrims on flame and is used in pyrotechnics. It is also used as a pyrotechnic in welding and brazing fluxes.

Physical properties

White cubic crystals; granules or powder; hygroscopic; sharp salt-like taste; refractive index 1.662; density 2.068 g/cm³; melts at 605°C; vaporizes around 1,360°C; readily dissolves in water (64g/100mL at 0°C); also highly soluble in alcohol and pyridine; moderately soluble in acetone (4.1 g/100mL at 25°C).

Uses

Lithium chloride is useful for the production of lithium metal, and for the generation of Mn(0) species which can be used in free radical cyclizations. It can serve as a flame colorant to generate dark red flames, a brazing flux for aluminum in automobiles, a hygrometer, and a desiccant for drying air streams. On exposure to air, it becomes a solution with the concentration directly related to relative humidity of the atmosphere, and hence serves as a relative humidity standard in calibrating hygrometers. Apart from being a source of chloride, it serves as an additive in the Stille reaction in organic synthesis, and to precipitate RNA from cellular extracts. Being biologically significant, it finds applications in a wide variety of assays to study cell-fate and neurobiology. Lithium chloride has been found to inhibit virus infection.

Application

Lithium chloride solution can be used:
(1) obtaining dendritic cells in the form of LiClPAM3 DCs;
(2) LiCl buffer preparation for immunoprecipitation;
(3) in the preparation of washing buffers;
(4) in the preparation of washing buffers for radioimmunoprecipitation assays (RIPA);
(5) can be used for selective precipitation of RNA.

Definition

ChEBI: Lithium chloride is a metal chloride salt with a Li(+) counterion. It has a role as an antimanic drug and a geroprotector. It is an inorganic chloride and a lithium salt.

Preparation

Lithium chloride may be prepared by reaction of lithium carbonate or lithium hydroxide with hydrochloric acid followed by crystallization:
(1) Li2CO3+ 2HCl →2LiCl + CO2+ H2O
(2) LiOH + HCl →LiCl + H2O
Crystallization above 95°C yields anhydrous salt. Hot solution upon cooling forms crystals of monohydrate, LiCl.H2O.
The solid and solution are separated and the supernatant solution is recycled for further evaporation. The crystals are dried to yield anhydrous lithium chloride.
Lithium chloride can be synthesized from its elements by heating lithium metal with chlorine gas.
It also may be obtained from natural brine.

General Description

Colorless crystals or powder. Low toxicity.

Air & Water Reactions

Very hygroscopic. Very soluble in water.

Reactivity Profile

These materials have weak oxidizing or reducing powers. Redox reactions can however still occur. For example, CO2, which is often regarded as chemically inert, vigorously oxidizes the strong reducing agent Mg if the two are heated together. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive. Some do react with acids: carbonates generate carbon dioxide and heat when treated with acids; fluorides, sulfites and sulfides generate toxic gases (hydrogen fluoride, sulfur dioxide and hydrogen sulfide, respectively) when treated with acids.

Fire Hazard

Flash point data for Lithium chloride are not available. Lithium chloride is probably combustible.

Industrial uses

Lithium chloride solutions are used in large dehumidification systems in the air-conditioning industry. This use depends on the low equilibrium pressure of water vapor above solutions of lithium chloride. After the solutions have absorbed water, they are regenerated by heating.
Lithium chloride is used in a number of salt mixtures. Such salt mixtures have low melting points allowing the material to be used in brazing fluxes and brazing baths. The molten lithium chloride-potassium chloride eutectic mixture can be used as an electrolyte. The mixture is electrolyzed for the production of lithium metal and is used as an electrolyte in voltaic cells.
Lithium chloride is also used in manufacture of mineral waters; in pyrotechnics; soldering aluminum; in refrigerating machines.

Biochem/physiol Actions

Lithium chloride has the ability to block glycogen synthase kinase (GSK). It may also possess anti-inflammatory effects at low and non-toxic concentrations.

Safety Profile

Human poison by ingestion. Experimental poison by intravenous and intracerebral routes. Moderately toxic by subcutaneous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: somnolence, tremors, nausea or vomiting. An eye and severe skin irritant. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. This material has been recommended and used as a substitute for sodwm chloride in "saltfree" diets, but cases have been reported in which the ingestion of lithium chloride has produced dminess, ringing in the ears, visual disturbances, tremors, and mental confusion. In most cases, the symptoms disappeared when use was discontinued. Prolonged absorption may cause disturbed electrolyte balance, impaired renal function. Reaction is violent with BrF3. When heated to decomposition it emits toxic fumes of Cl-. Used for dehumidification in the air conditioning industry. Also used to obtain lithum metal. See also LITHIUM COMPOUNDS.

Purification Methods

Crystallise it from water (1mL/g) or MeOH and dry it for several hours at 130o. Other metal ions can be removed by preliminary crystallisation from hot aqueous 0.01M disodium EDTA. It has also been crystallised from conc HCl, fused in an atmosphere of dry HCl gas, cooled under dry N2 and pulverised in a dry-box. Kolthoff and Bruckenstein [J Am Chem Soc 74 2529 1952] precipitated it with ammonium carbonate, washed it with Li2CO3 five times by decantation and finally with suction, then dissolved it in HCl. The LiCl solution is evaporated slowly with continuous stirring in a large evaporating dish, the dry powder being stored (while still hot) in a desiccator over CaCl2.

Lithium chloride Preparation Products And Raw materials

Raw materials

Lithium hydroxide Lithium carbonate Hydrochloric acid

Preparation Products

5-CHLORO-2'-DEOXYURIDINE Methyl 3-cyclopentenecarboxylate Mometasone furoate 3,5-DIMETHOXYPHENYLACETIC ACID 5-AMINOMETHYL-PYRROLIDIN-2-ONE

5-Hydroxymethylpyrrolidin-2-one [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) 5-Fluoro-2-oxindole (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL Halobetasol propionate

2-Chloro-6-fluorophenylacetic acid 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE Mn(Ⅲ)salen epoxidation catalyst Diphenylacetylene 2,5-DIMETHYL-1,3-OXAZOLE-4-CARBALDEHYDE

1,3-CYCLOHEXADIENE 1-(3-AMINO-PYRIDIN-2-YL)-ETHANONE LITHIUM DICHROMATE optical plastics based on coplymer of diene macromolecule 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE

6-Chlorooxindole METHYL 2-CHLORO-6-FLUOROPHENYLACETATE Lithium

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Lithium chloride Suppliers

Global( 725)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7378	58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	532-83657313	hjt@hong-jin.com	China	228	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Shanghai Worldyang Chemical Co.,Ltd.	,+86-21-56795779; +8613651600618	sales@worldyachem.com	China	879	58
Hebei Dangtong Import and export Co LTD	+8615632927689	admin@hbdangtong.com	China	991	58
Hebei Dongdu Import and Export Co. LTD	+86-15333296769 +86-15333296769	manager@cndongdu.com	China	71	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-13102810335	admin@hbsaisier.cn	China	366	58
Yujiang Chemical (Shandong) Co.,Ltd.	+86-17736087130 +86-18633844644	catherine@yjchem.com.cn	China	83	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	58
Xiamen AmoyChem Co., Ltd	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Hebei Dangtong Import and export Co LTD	58
Hebei Dongdu Import and Export Co. LTD	58
Hebei Saisier Technology Co., LTD	58
Yujiang Chemical (Shandong) Co.,Ltd.	58
Hebei Guanlang Biotechnology Co,.LTD	58
Hebei Jingbo New Material Technology Co., Ltd	58

View Lastest Price from Lithium chloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	Lithium chloride 7447-41-8	US $2.00 / kg	1kg	99%	300tons	Hebei Dangtong Import and export Co LTD
2024-04-16	Lithium Chloride	US $49.00 / kg	1kg	99.99%	10T	Yujiang Chemical (Shandong) Co.,Ltd.
2024-04-15	Lithium Chloride 7447-41-8	US $1.00 / g	10g	99	20ton	ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Lithium chloride
7447-41-8
US $2.00 / kg
99%
Hebei Dangtong Import and export Co LTD

Lithium Chloride
US $49.00 / kg
99.99%
Yujiang Chemical (Shandong) Co.,Ltd.

Lithium Chloride
7447-41-8
US $1.00 / g
99
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Lithium chloride Spectrum

Lithium chloride(7447-41-8)IR1

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