ChemicalBook
Chinese Japanese Germany Korea

Trichloroacetic acid

General Description Application Preparation
Trichloroacetic acid
Trichloroacetic acid structure
CAS No.
76-03-9
Chemical Name:
Trichloroacetic acid
Synonyms
TCA;nata;TKhU;TkhV;NA TA;natal;TKhUK;TkhVk;500ml;tecane
CBNumber:
CB9854255
Molecular Formula:
C2HCl3O2
Formula Weight:
163.39
MOL File:
76-03-9.mol

Trichloroacetic acid Properties

Melting point:
54-58 °C (lit.)
Boiling point:
196 °C (lit.)
Density 
1.62 g/mL at 25 °C (lit.)
vapor density 
<1 (vs air)
vapor pressure 
1 mm Hg ( 51 °C)
refractive index 
n20/D 1.62(lit.)
Flash point:
196°C
storage temp. 
Store at +15°C to +25°C.
solubility 
H2O: 0.5 M at 20 °C, clear, colorless
pka
0.7(at 25℃)
form 
Solid
color 
White
PH
<1.0 (25℃, 0.5M in H2O)
Water Solubility 
120 g/100 mL (20 ºC)
Sensitive 
Hygroscopic
λmax
210nm(EtOH)(lit.)
Merck 
14,9627
BRN 
970119
Stability:
Stable, but moisture sensitive. Incompatible with water, strong bases. Note that the Merck Index states that this material is hydrolytically unstable in aqueous solution below 30% by weight. Decomposition products include carbon monoxide and carbon dioxide. The generation of these gases in a sealed container may lead to a pressure rise sufficien
CAS DataBase Reference
76-03-9(CAS DataBase Reference)
EWG's Food Scores
3-6
FDA UNII
5V2JDO056X
Proposition 65 List
Trichloroacetic Acid
IARC
2B (Vol. 63, 84, 106) 2014
NIST Chemistry Reference
Acetic acid, trichloro-(76-03-9)
EPA Substance Registry System
Trichloroacetic acid (76-03-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS02,GHS07,GHS05,GHS09
Signal word  Danger
Hazard statements  H400-H315-H318-H335-H336-H351-H373-H410-H225-H412-H314-H401-H411
Precautionary statements  P273-P280-P305+P351+P338+P310-P391-P501-P210-P370+P378-P403+P235-P303+P361+P353-P304+P340+P310-P305+P351+P338-P260-P260h-P301+P330+P331-P405-P501a
Hazard Codes  Xn,N,C,F,Xi
Risk Statements  36/37/38-40-51/53-50/53-35-38-11-34-67-52/53
Safety Statements  26-36/37-61-60-45-36/37/39-24/25-16
RIDADR  UN 1839 8/PG 2
WGK Germany  2
RTECS  AJ7875000
10-21
Autoignition Temperature 711 °C
Hazard Note  Corrosive/Hygroscopic
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29154000
Toxicity LD50 orally in rats: 5000 mg/kg (Bailey, White)
NFPA 704
0
3 0

Trichloroacetic acid price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.22342 Trichloroacetic acid for synthesis 76-03-9 25 g $20.53 2021-03-22 Buy
Sigma-Aldrich 1.00810 Trichloroacetic acid cryst., EMPROVE? ESSENTIAL Ph Eur 76-03-9 250 g $55.5 2021-03-22 Buy
Sigma-Aldrich 1.00807 Trichloroacetic acid for analysis EMSURE? ACS,Reag. Ph Eur 76-03-9 100 g $56.98 2021-03-22 Buy
Sigma-Aldrich 8.22342 Trichloroacetic acid for synthesis 76-03-9 250 g $61.51 2021-03-22 Buy
Sigma-Aldrich 1.00807 Trichloroacetic acid for analysis EMSURE? ACS,Reag. Ph Eur 76-03-9 250 g $79.73 2021-03-22 Buy

Trichloroacetic acid Chemical Properties,Uses,Production

General Description

It is briefly referred to as TCA. It appears as colorless or white orthorhombic crystal with strong deliquescence. It has slight special irritating smell with strong corrosiveness. The aqueous solution of TCA is strongly acidic, and the aqueous solution of 0.1 mol of solution having a pH of 1.2. TCA with concentration of 30% or less is difficult to be stored for a long period of time since it is gradually decomposed into chloroform, hydrogen chloride, carbon dioxide, carbon monoxide and the like. In dilute alkali, it will be hydrolyzed into chloroform and carbon dioxide. Formic acid is formed in concentrated alkali. It is a strong corrosion products with a oral LD50 being 3320mg / kg.
Trichloroacetic acid is a strong organic acid with a dissociation constant K = 3 × 10-2. It has lively chemical properties. Its sodium salt is easily subject to decarboxylation into chloroform. It will be reduced to alcohol upon coming across LiAlH4. It can have halogen replacement reaction with KBr:

Application

Trichloroacetic acid can be used as pharmaceutical raw materials, herbicides (potassium trichloroacetate and sodium trichloroacetate, etc.), textile dyeing auxiliaries, metal surface treatment agent and acid chloride, anhydride, amide, polyester, organometallic salt, water salicylaldehyde, chlorocarboxylic acid and the raw materials of other organic synthesis. 
In addition, in medicine, it can also be used as etherifying agents and keratolytics, bile pigment reagents and protein precipitation reagents. In the field of biochemistry, it can be used for separation analysis of biological phosphate compounds and reagents for determination of fluoride and lipid as well as microscopic fixative, decalcification, chromatography reagents.
The product is warts agent and astringent in pharmaceutical field, mainly used as biochemical drug extractant for the extraction of many highly efficient drugs such as adenosine triphosphate, cytochrome C and placental polysaccharides.
In addition, trichloroacetic acid, together with alkaline phenol, can be used for salicylaldehyde compound synthesis by ReimerTiemann reaction. It can also react with monoolefine compounds for synthesizing chlorocarboxylic acid [CCl3 (CH2CH2) nCOOH] .

Preparation

  1. Use acetic acid or monochloroacetic acid as raw material; gradually warm in the 100~ 150℃ in the presence of the light or catalyst (ferric chloride) for chlorination to obtain it.
  2. Use hydrated chloral hydrate as raw material; apply oxidation reaction using concentrated nitric acid to obtain it.

Chemical Properties

Trichloroacetic acid is a colorless crystalline solid which is used in liquid solutions.

Chemical Properties

Trichloroacetic acid, is a colorless crystalline solid. Trichloroacetic acid absorbs moisture from air and forms a syrup. Trichloroacetic acid is soluble in water with release of heat. Trichloroacetic acid is corrosive to metals and tissue.

Uses

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative, as a laboratory reagent, a herbicide, in medicine, and in microscopy.

Uses

Trichloroacetate (TCA) is used primarily for the selective control of annual and perennial grass weeds in cropland and noncropland. TCA is acidic in nature and are not strongly sorbed by soils. It is reported to be rapidly degraded in both soil and water by microbial processes. However, the breakdown of TCA occurs very slowly when incubated at 14–15 °C in acidic soils. iming not only accelerates this degradation but also increases the numbers of TCA-degrading bacteria.

Uses

As a reagent for albumin detection; in making herbicides. It is found as a by-product after chlorination of water containing humic materials.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.

Reactivity Profile

Trichloroacetic acid is a strong acid; when heated, in the presence of water, decomposes forming phosgene and HCl. [Handling Chemicals Safely 1980 p. 915]. The acid was added to copper wool and rinsed down with dimethyl sulfoxide. This caused what was thought to be an extremely exothermic dehydrohalogenation reaction that melted the neck of the flask, [Chem. Eng. News, 1981, 59(28), 4].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion and subcutaneous routes. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic data. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of Cland Na2O. Used as an herbicide.

Potential Exposure

This haloacetic acid can be a byproduct of drinking water disinfection and may increase the risk of cancer. Trichloroacetic acid is used as medication; in organic syntheses; as a reagent for albumin detection; as an intermediate in pesticide manufacture and in the production of sodium trichloroacetate which is itself a herbicide.

Carcinogenicity

TCA was not mutagenic in bacterial assays.The IARC has determined that there is limited evidence for the carcinogenicity of TCA in experimental animals and that it is not classifiable as to its carcinogenicity to humans. Neutralized TCA was not clastogenic in human lymphocytes in vitro or in the mouse bone marrow micronucleus test.

Shipping

UN1839 (solid) & UN2564 (solution) Trichloroacetic acid, solid and Trichloroacetic acid, solution, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Purify the acid by fractional crystallisation from its melt, then crystallise it repeatedly from dry *benzene and store it over conc H2SO4 in a vacuum desiccator. It can also be crystallised from CHCl3 or cyclohexane, and dried over P2O5 or Mg(ClO4)2 in a vacuum desiccator. Trichloroacetic acid can be fractionally distilled under reduced pressure from MgSO4. Layne, Jaffé and Zimmer [J Am Chem Soc 85 435 1963] dried trichloroacetic acid in *benzene by distilling off the *benzene-water azeotrope, then crystallised the acid from the remaining *benzene solution. Manipulations should be carried out under N2. [Toxic vapours, use a well ventilated fume cupboard.] [Beilstein 2 IV 508.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, silver salts, strong acids, strong bases, moisture, iron, zinc, aluminum. Corrosive to iron, steel and other metals.

References

https://pubchem.ncbi.nlm.nih.gov/compound/trichloroacetic_acid#section=Top
https://en.wikipedia.org/wiki/Trichloroacetic_acid

Trichloroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Trichloroacetic acid Suppliers

Global( 312)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58

View Lastest Price from Trichloroacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Trichloroacetic Acid
76-03-9
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-29 Trichloroacetic acid
76-03-9
US $100.00 / KG 1KG Above99% Weekly supply of 1000KG Wuhan Dujiang Industrial Co., Ltd.
2021-07-13 Trichloroacetic Acid
76-03-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Trichloroacetic acid Spectrum


76-03-9(Trichloroacetic acid)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved