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Trichloroacetic acid

General Description Application Preparation
Trichloroacetic acid
Trichloroacetic acid structure
Chemical Name:
Trichloroacetic acid
TCA;nata;TKhU;TkhV;500ml;NA TA;natal;TKhUK;TkhVk;tecane
Molecular Formula:
Formula Weight:
MOL File:

Trichloroacetic acid Properties

Melting point:
54-58 °C(lit.)
Boiling point:
196 °C(lit.)
1.62 g/mL at 25 °C(lit.)
vapor density 
<1 (vs air)
vapor pressure 
1 mm Hg ( 51 °C)
refractive index 
n20/D 1.62(lit.)
Flash point:
storage temp. 
H2O: 0.5 M at 20 °C, clear, colorless
0.7(at 25℃)
<1.0 (25℃, 0.5M in H2O)
Water Solubility 
120 g/100 mL (20 ºC)
Stable, but moisture sensitive. Incompatible with water, strong bases. Note that the Merck Index states that this material is hydrolytically unstable in aqueous solution below 30% by weight. Decomposition products include carbon monoxide and carbon dioxide. The generation of these gases in a sealed container may lead to a pressure rise sufficien
CAS DataBase Reference
76-03-9(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, trichloro-(76-03-9)
EPA Substance Registry System
Acetic acid, trichloro-(76-03-9)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,C,F,Xi
Risk Statements  36/37/38-40-51/53-50/53-35-38-11-34-67-52/53
Safety Statements  26-36/37-61-60-45-36/37/39-24/25-16
RIDADR  UN 1839 8/PG 2
WGK Germany  2
RTECS  AJ7875000
Autoignition Temperature 711 °C
Hazard Note  Corrosive/Hygroscopic
HazardClass  8
PackingGroup  II
HS Code  29154000
Hazardous Substances Data 76-03-9(Hazardous Substances Data)
Toxicity LD50 orally in rats: 5000 mg/kg (Bailey, White)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Trichloroacetic acid price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 27242 Trichloroacetic acid puriss., meets analytical specification of Ph. Eur., USP 21, 99-100.5% (calc. to the dried substance) 76-03-9 1kg-r $214 2018-11-13 Buy
Sigma-Aldrich 27242 Trichloroacetic acid puriss., meets analytical specification of Ph. Eur., USP 21, 99-100.5% (calc. to the dried substance) 76-03-9 6x1kg-r $977 2018-11-13 Buy
TCI Chemical T0369 Trichloroacetic Acid >99.0%(T) 76-03-9 25g $15 2018-11-22 Buy
TCI Chemical T0369 Trichloroacetic Acid >99.0%(T) 76-03-9 500g $67 2018-11-22 Buy
Alfa Aesar 022156 Trichloroacetic acid, ACS 99% min 76-03-9 250g $70 2018-11-20 Buy

Trichloroacetic acid Chemical Properties,Uses,Production

General Description

It is briefly referred to as TCA. It appears as colorless or white orthorhombic crystal with strong deliquescence. It has slight special irritating smell with strong corrosiveness. The aqueous solution of TCA is strongly acidic, and the aqueous solution of 0.1 mol of solution having a pH of 1.2. TCA with concentration of 30% or less is difficult to be stored for a long period of time since it is gradually decomposed into chloroform, hydrogen chloride, carbon dioxide, carbon monoxide and the like. In dilute alkali, it will be hydrolyzed into chloroform and carbon dioxide. Formic acid is formed in concentrated alkali. It is a strong corrosion products with a oral LD50 being 3320mg / kg.
Trichloroacetic acid is a strong organic acid with a dissociation constant K = 3 × 10-2. It has lively chemical properties. Its sodium salt is easily subject to decarboxylation into chloroform. It will be reduced to alcohol upon coming across LiAlH4. It can have halogen replacement reaction with KBr:


Trichloroacetic acid can be used as pharmaceutical raw materials, herbicides (potassium trichloroacetate and sodium trichloroacetate, etc.), textile dyeing auxiliaries, metal surface treatment agent and acid chloride, anhydride, amide, polyester, organometallic salt, water salicylaldehyde, chlorocarboxylic acid and the raw materials of other organic synthesis. 
In addition, in medicine, it can also be used as etherifying agents and keratolytics, bile pigment reagents and protein precipitation reagents. In the field of biochemistry, it can be used for separation analysis of biological phosphate compounds and reagents for determination of fluoride and lipid as well as microscopic fixative, decalcification, chromatography reagents.
The product is warts agent and astringent in pharmaceutical field, mainly used as biochemical drug extractant for the extraction of many highly efficient drugs such as adenosine triphosphate, cytochrome C and placental polysaccharides.
In addition, trichloroacetic acid, together with alkaline phenol, can be used for salicylaldehyde compound synthesis by ReimerTiemann reaction. It can also react with monoolefine compounds for synthesizing chlorocarboxylic acid [CCl3 (CH2CH2) nCOOH] .


  1. Use acetic acid or monochloroacetic acid as raw material; gradually warm in the 100~ 150℃ in the presence of the light or catalyst (ferric chloride) for chlorination to obtain it.
  2. Use hydrated chloral hydrate as raw material; apply oxidation reaction using concentrated nitric acid to obtain it.

Chemical Properties

Trichloroacetic acid is a colorless crystalline solid which is used in liquid solutions.

Chemical Properties

Trichloroacetic acid, is a colorless crystalline solid. Trichloroacetic acid absorbs moisture from air and forms a syrup. Trichloroacetic acid is soluble in water with release of heat. Trichloroacetic acid is corrosive to metals and tissue.


Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative, as a laboratory reagent, a herbicide, in medicine, and in microscopy.


ChEBI: A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.

Reactivity Profile

Trichloroacetic acid is a strong acid; when heated, in the presence of water, decomposes forming phosgene and HCl. [Handling Chemicals Safely 1980 p. 915]. The acid was added to copper wool and rinsed down with dimethyl sulfoxide. This caused what was thought to be an extremely exothermic dehydrohalogenation reaction that melted the neck of the flask, [Chem. Eng. News, 1981, 59(28), 4].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion and subcutaneous routes. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic data. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of Cland Na2O. Used as an herbicide.

Potential Exposure

This haloacetic acid can be a byproduct of drinking water disinfection and may increase the risk of cancer. Trichloroacetic acid is used as medication; in organic syntheses; as a reagent for albumin detection; as an intermediate in pesticide manufacture and in the production of sodium trichloroacetate which is itself a herbicide.


UN1839 (solid) & UN2564 (solution) Trichloroacetic acid, solid and Trichloroacetic acid, solution, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Purify the acid by fractional crystallisation from its melt, then crystallise it repeatedly from dry *benzene and store it over conc H2SO4 in a vacuum desiccator. It can also be crystallised from CHCl3 or cyclohexane, and dried over P2O5 or Mg(ClO4)2 in a vacuum desiccator. Trichloroacetic acid can be fractionally distilled under reduced pressure from MgSO4. Layne, Jaffé and Zimmer [J Am Chem Soc 85 435 1963] dried trichloroacetic acid in *benzene by distilling off the *benzene-water azeotrope, then crystallised the acid from the remaining *benzene solution. Manipulations should be carried out under N2. [Toxic vapours, use a well ventilated fume cupboard.] [Beilstein 2 IV 508.]


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, silver salts, strong acids, strong bases, moisture, iron, zinc, aluminum. Corrosive to iron, steel and other metals.


Trichloroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Trichloroacetic acid Suppliers

Global( 262)Suppliers
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Hebei Guanlang Biotechnology Co., Ltd.
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Mainchem Co., Ltd.
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Hubei Jusheng Technology Co.,Ltd.
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View Lastest Price from Trichloroacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 Trichloroethylene
US $1.00 / KG 1KG 99% 25kg career henan chemical co
2019-07-05 Trichloroacetic acid
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Trichloroacetic acid Spectrum

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