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Mephenoxalone

Mephenoxalone
Mephenoxalone structure
CAS No.
70-07-5
Chemical Name:
Mephenoxalone
Synonyms
Xerene;Dorsiflex;Metoxadone;Methoxydone;mephenoxalone;5-(o-MethoxyphenoxyMethyl)-2-oxazolidinone;5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone;5-[(2-methoxyphenoxy)methyl]oxazolidin-2-one;2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]-;5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
CBNumber:
CB9887684
Molecular Formula:
C11H13NO4
Formula Weight:
223.23
MOL File:
70-07-5.mol

Mephenoxalone Properties

Melting point:
143-145°
Boiling point:
364.51°C (rough estimate)
Density 
1.2446 (rough estimate)
refractive index 
1.4960 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
12.24±0.40(Predicted)
FDA UNII
CZ87T54W8W
ATC code
N05BX01
NIST Chemistry Reference
2-Oxazolidinone, 5-[(o-methoxyphenoxy)methyl]-(70-07-5)
SAFETY
  • Risk and Safety Statements
Toxicity LD50 orally in rats: 3820 ±17 mg/kg (Goldenthal)

Mephenoxalone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M224900 Mephenoxalone 70-07-5 25mg $135 2021-12-16 Buy
American Custom Chemicals Corporation API0008047 MEPHENOXALONE 95.00% 70-07-5 25MG $510 2021-12-16 Buy
American Custom Chemicals Corporation API0008047 MEPHENOXALONE 95.00% 70-07-5 250MG $1280 2021-12-16 Buy
Chemenu CM128782 5-((2-methoxyphenoxy)methyl)oxazolidin-2-one 95% 70-07-5 1g $333 2021-12-16 Buy

Mephenoxalone Chemical Properties,Uses,Production

Originator

Trepidone,Lederle, ,1961

Uses

Mephenoxalone is used as a muscle relaxant, also as a mild tranquilizer.

Uses

Prostaglandin F2á ethyl amide Lumigan (0.03% bimatoprost ophthalmic solution)

Uses

Muscle relaxant, also used as a mild tranquilizer.

Manufacturing Process

A mixture of 24.1 g (0.10 mol) of 3-o-methoxyphenoxy-2-hydroxy-1-propyl carbamate and 6.0 g (0.10 mol) of urea was heated rapidly to the temperature range of 180°C to 200°C, and maintained there for five hours. The reaction melt was poured into 50% ethyl alcohol, from which the product crystallized as a white solid. The crude yield was 18.3 g (82%); melting point 131.5% to 137°C. Crystallization from water and 95% alcohol gave 9.0 g (40.3 %) of pure 5-o-methoxyphenoxymethyl-2-oxazolidone; melting point 141°C to 143°C. This melting point was not depressed when the material was mixed with an authentic sample. In additional runs acetone was used instead of ethyl alcohol with equivalent results.
It was found that when the heating time was reduced to three hours and a reaction temperature of 190°C to 200°C was maintained, equivalent yields (40 to 50%) were obtained, but that the yields were appreciably lowered when the heating time was further reduced to two hours. It was also found that when the temperature was lowered to the range of 170°C to 180°C the yield was significantly lowered.
When the material was isolated by extraction with chloroform and distillation, the yield of pure material was 58.5%.

brand name

MI. Lenetran (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

Mephenoxalone Preparation Products And Raw materials

Raw materials

Preparation Products


Mephenoxalone Suppliers

Global( 41)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
SIMAGCHEM CORP
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Dayang Chem (Hangzhou) Co.,Ltd.
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Hong Kong Excellence Biotechnology Co., Ltd.
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Amadis Chemical Company Limited
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J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
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Chemsky (shanghai) International Co.,Ltd 021-50135380
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Shanghai YuanYe Biotechnology Co., Ltd. 18572826883 021-61312824-
QQ:3008007432 3008007432@qq.com China 30311 60
Guangzhou Kafen Biotech Co.,Ltd 18029243487 QQ:2355327168
020-31121510 gy@yccreate.com China 4762 55
Aikon International Limited 13611564524 025-58851090-
(3)02557626880 cfzhang@aikonchem.com China 15849 58
Foshan DaoQi Biological Co., Ltd. 18062666947
18062666959 2355880548@qq.com China 4230 58

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