ChemicalBook >> CAS DataBase List >>3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester
3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester
![3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Structure](CAS/20210305/GIF/303141-21-1.gif)
- CAS No.
- 303141-21-1
- Chemical Name:
- 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester
- Synonyms
- DC-S239;Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate;3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester;Histone Methyltransferase,Ethyl 2 amino 4 methyl 5 [(3 nitrophenyl)carbamoyl]thiophene 3 carboxylate,anti-cancer,HL60,SET7 inhibitor,MV4-11,MCF7,Ethyl 2amino4methyl5[(3nitrophenyl)carbamoyl]thiophene3carboxylate,inhibit,Inhibitor
- CBNumber:
- CB99042307
- Molecular Formula:
- C15H15N3O5S
- Molecular Weight:
- 349.36
- MDL Number:
- MOL File:
- 303141-21-1.mol
Last updated:2024-07-02 08:55:42
3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Properties
| Boiling point | 479.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.440±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 125 mg/mL (357.80 mM; Need ultrasonic) |
| pka | 11.12±0.70(Predicted) |
| form | Solid |
| color | Yellow to orange |
3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Chemical Properties,Uses,Production
Biological Activity
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity[1]. DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, while it inhibits SET7 by 90% at concentrations of 100 μM[1].DC-S239 (0-100 μM, 120 h) can inhibit the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner but no significant effect on the activity of HCT116 and DHL4 cells[1].
References
[1]. Fanwang Meng, et al. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem. 2015 Oct 22;58(20):8166-81.
3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Suppliers
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3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester
DC-S239
Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate
Histone Methyltransferase,Ethyl 2 amino 4 methyl 5 [(3 nitrophenyl)carbamoyl]thiophene 3 carboxylate,anti-cancer,HL60,SET7 inhibitor,MV4-11,MCF7,Ethyl 2amino4methyl5[(3nitrophenyl)carbamoyl]thiophene3carboxylate,inhibit,Inhibitor
303141-21-1