N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide
- CAS No.
- 96-88-8
- Chemical Name:
- N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide
- Synonyms
- C07528;Carbocain;Polocaine;Mepicaine;Carbocaine;Scandicain;Scandicaine;DL-Mepivacaine;1-Methyl-2',6'-pipecoloxylidide;Mepivacaine (base and/or unspecified salts)
- CBNumber:
- CB9907386
- Molecular Formula:
- C15H22N2O
- Molecular Weight:
- 246.35
- MDL Number:
- MFCD00243006
- MOL File:
- 96-88-8.mol
| Melting point | 150-151° |
|---|---|
| Boiling point | 389.35°C (rough estimate) |
| Density | 0.9978 (rough estimate) |
| refractive index | 1.6280 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | A crystalline solid |
| pka | 14.85±0.70(Predicted) |
| Water Solubility | 2.217g/L(25 ºC) |
| FDA UNII | B6E06QE59J |
| NCI Drug Dictionary | Carbocaine |
| EPA Substance Registry System | 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (96-88-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23402 | Mepivacaine ≥98% | 96-88-8 | 1mg | $31 | 2024-03-01 | Buy |
| Cayman Chemical | 23402 | Mepivacaine ≥98% | 96-88-8 | 5mg | $74 | 2024-03-01 | Buy |
| TRC | M225078 | Mepivacaine | 96-88-8 | 100mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015834 | N-(2,6-DIMETHYLPHENYL)-1-METHYLPIPERIDINE-2-CARBOXAMIDE 95.00% | 96-88-8 | 10G | $1334.03 | 2021-12-16 | Buy |
| ChemScene | CS-0009492 | Mepivacaine ≥98.0% | 96-88-8 | 500mg | $80 | 2021-12-16 | Buy |
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide Chemical Properties,Uses,Production
Originator
Carboraine,Winthrop,US,1960
Uses
Mepivacaine can be used in biological study of 2-adamantanamine produces prolonged spinal block in rats.
Uses
Anesthetic (local).
Definition
ChEBI: A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Manufacturing Process
Ethyl magnesium bromide is prepared in the usual way by reacting 185 parts by weight of ethyl bromide in 800 parts of anhydrous ether with 37 parts by weight of magnesium turnings. Under vigorous stirring 121 parts of 2,6- dimethyl aniline are added at a rate depending on the vigor of the gas evaporation. When the evolution of gas has ceased, 85 parts by weight of Nmethylpipecolic acid ethyl ester are added to the 2,6-dimethyl aniline magnesium bromide slurry. The mixture is refluxed for ? hour with continued stirring, after which it is cooled down. Dilute hydrochloric acid is added carefully in order to dissolve and hydrolyze the magnesium compound formed.
The pH is adjusted to 5.5 and the water phase separated and extracted with additional ether in order to remove the surplus dimethyl aniline. After addition of an excess of ammonia to the solution, the reaction product, Nmethylpipecolic acid 2,6-dimethyl anilide, is recovered by extraction with isoamyl alcohol. The isoamyl alcohol solution is evaporated to dryness, the product dissolved in dilute hydrochloric acid, treated with charcoal and reprecipitated with NaOH. N-methylpipecolic acid 2,6-dimethyl anilide is obtained in crystalline form.
brand name
Arestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco).
Therapeutic Function
Local anesthetic
Safety Profile
Poison by intravenous route. Moderately toxic by subcutaneous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Honest Joy Holdings Limited | 755-36694831 +8613798234863 | Linda.zhou@debayer.com | China | 999 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 17938 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | +8618575662672 18575662672 | mzeng@3wpharm.com | China | 10070 | 57 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5654 | 65 |
View Lastest Price from N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-19 | Mepivacaine
96-88-8
|
US $0.00 / KG | 1KG | 99.0% | 100 tons | Honest Joy Holdings Limited
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- Mepivacaine
96-88-8
- US $0.00 / KG
- 99.0%
- Honest Joy Holdings Limited