hydroxocobalamin monohydrochloride
- CAS No.
- 59461-30-2
- Chemical Name:
- hydroxocobalamin monohydrochloride
- Synonyms
- Einecs 261-772-4;Vitamin B12a monohydrochloride;Hydroxocobalain onohydrochloride;hydroxocobalamin monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride);Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
- CBNumber:
- CB9927953
- Molecular Formula:
- C62H89ClCoN13O15P
- Molecular Weight:
- 1381.83
- MDL Number:
- MFCD00167463
- MOL File:
- 59461-30-2.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | methanol: soluble10mg/mL at 20°C, clear, dark red |
| FDA UNII | B2B1VB7X21 |
hydroxocobalamin monohydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 95200 | Vitamin B12a hydrochloride ≥96% (UV), ≥96% (HPLC) | 59461-30-2 | 1g | $199.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1324319 | Hydroxocobalamin chloride United States Pharmacopeia (USP) Reference Standard | 59461-30-2 | 3x150mg | $460 | 2024-03-01 | Buy |
| Sigma-Aldrich | H7126 | Vitamin B12a hydrochloride analytical standard | 59461-30-2 | 100mg | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | H7126 | Vitamin B12a hydrochloride analytical standard | 59461-30-2 | 1g | $198.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 95200 | Vitamin B12a hydrochloride ≥96% (UV), ≥96% (HPLC) | 59461-30-2 | 250mg | $111 | 2024-03-01 | Buy |
hydroxocobalamin monohydrochloride Chemical Properties,Uses,Production
Biological Activity
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable, natural vitamin B12 with a favorable adverse reaction profile that can be used as a dietary supplement for vitamin B12 deficiency, including pernicious anemia.
in vitro
The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro .
in vivo
Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg ip) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg ip) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).
More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) was given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.
hydroxocobalamin monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
hydroxocobalamin monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8147 | 55 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-58362220 15250997978 | 1511893459@qq.com | China | 7715 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Anhui kuer Bioengineering Co., Ltd | 0551-65171243 13810511747 | kuer@kuerhuaxue.com | China | 2997 | 55 |
| Shenzhen Botel Biotechnology Co. Ltd. | 0755-22202135 13316968096 | 1979313431@qq.com | China | 7642 | 58 |