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Aliskiren

Aliskiren structure

CAS No.: 173334-57-1

Chemical Name:: Aliskiren

Synonyms: CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%

CBNumber:: CB9966226

Molecular Formula:: C30H53N3O6

Molecular Weight:: 551.76

MDL Number:: MFCD09839018

MOL File:: 173334-57-1.mol

MSDS File:: SDS

Last updated:2024-04-16 14:59:45

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Aliskiren Properties

Melting point	98-99 °C
Boiling point	748.4±60.0 °C(Predicted)
Density	1.067±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
form	Powder
pka	9.49(at 25℃)
CAS DataBase Reference	173334-57-1(CAS DataBase Reference)
FDA UNII	502FWN4Q32
ATC code	C09XA02

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338

Aliskiren price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS023114	Aliskiren	173334-57-1	10MG	$209	2024-03-01	Buy
ChemScene	CS-0443	Aliskiren 99.16%	173334-57-1	50mg	$240	2021-12-16	Buy
ApexBio Technology	A3153	Aliskiren	173334-57-1	1g	$314	2021-12-16	Buy
Biosynth Carbosynth	FA134549	5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate	173334-57-1	2g	$350	2021-12-16	Buy
Biorbyt Ltd	orb611736	Aliskiren	173334-57-1	10mg	$460.7	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS023114	10MG	$209	Buy
CS-0443	50mg	$240	Buy
A3153	1g	$314	Buy
FA134549	2g	$350	Buy
orb611736	10mg	$460.7	Buy

Aliskiren Chemical Properties,Uses,Production

Description

Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .

Originator

Novartis (Switzerland)

Uses

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive

Uses

liquid crystal intermediate

Definition

ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.

brand name

Tekturna

General Description

Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Preparation Products And Raw materials

Raw materials

Preparation Products

Aliskiren Suppliers

Global( 186)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12452	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2504	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	744	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Casorganics US Corp	+17326109938	sales@casorganics.com	CHINA	174	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Casorganics US Corp	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Aliskiren manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-16	Aliskiren 173334-57-1	US $0.00 / kg	1kg	99%	20tons	Shaanxi TNJONE Pharmaceutical Co., Ltd
2023-08-02	Aliskiren 173334-57-1	US $50.00 / KG	1KG	99%	20tons	Hebei Mojin Biotechnology Co., Ltd
2023-08-02	Aliskiren 173334-57-1	US $30.00 / kg	1kg	99%	1000tons	Henan Bao Enluo International TradeCo.，LTD

Aliskiren
173334-57-1
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Aliskiren
173334-57-1
US $50.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Aliskiren
173334-57-1
US $30.00 / kg
99%
Henan Bao Enluo International TradeCo.，LTD

Aliskiren Spectrum

Aliskiren(173334-57-1)¹HNMR

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Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Aliskiren hemifumarate Aliskiren inter-8

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Aliskiren (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide CGP 60536 CGP60536B Rasilez SPP 100 Tekturna (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide ALISKIREN FREE BASE (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide Aliskiren (CGP 60536) Aliskiren (USAN) (2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide Aliskiren Base 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate Aliskiren, >=98% 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr CGP 60536;CGP60536B;SPP 100 CS-201 CGP-60536; CGP60536; TEKTURNA;SPP 100 Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)- Aliskiren USP/EP/BP (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide Aliskiren 99% CAS NO.173334-57-1 173334-57-1 C30H53N3O6HCl C30H53N3O6 C34H57N3O10 C30H53N3O6C4H4O4 API Amines Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Chemical Amines Aliskiren intermediates