ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Estrogen and progestin drugs >Nomegestrol

Nomegestrol

Nomegestrol Structure
CAS No.
58691-88-6
Chemical Name:
Nomegestrol
Synonyms
Monaco;TherMex;Nomegestrel;Nomegestrol;Normegestrel;NOMEGESTROL ACETATE;MELEGESTROL ACETATE;Nomegestrol USP/EP/BP;Nomegestrol###58691-88-6;17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
CBNumber:
CB4352983
Molecular Formula:
C21H28O3
Molecular Weight:
328.45
MOL File:
58691-88-6.mol
Modify Date:
2023/9/20 16:58:51

Nomegestrol Properties

Boiling point 502.6±50.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble
form A solid
pka 12.99±0.60(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Warning

Nomegestrol Chemical Properties,Uses,Production

Description

Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.

Uses

A progestogen, derivatives of which are used in contraceptives and hormone therapies.

General Description

Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.

Nomegestrol Preparation Products And Raw materials

Raw materials

Preparation Products

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MELEGESTROL ACETATE 17ALPHA-ACETOXY-6ALPHA-METHYL-19-NOR-PREGN-4,6-DIEN-3,20-DIONE NOMEGESTROL ACETATE Nomegestrol Nomegestrel 17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione (8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one (8S,9S,10R,13S,14S,17R)-17-ethanoyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one Monaco TherMex 19-Norpregna-4,6-diene-3,20-dione,17-hydroxy-6-Methyl- Nomegestrol###58691-88-6 Nomegestrol USP/EP/BP Normegestrel 58691-88-6 85652-20-3 Intermediates & Fine Chemicals Pharmaceuticals Steroids Steroid and Hormone